YKR012C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR012C / YKR012C

Click on Significant Values for Screen Details ID:SGTC_199|Compound:4063-0024|FD-Score:2.81|P-value:5.74E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.89|P-value:3.49E-6 ID:SGTC_291|Compound:4130-1278|FD-Score:3.01|P-value:2.43E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.26|P-value:7.94E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-2.82|P-value:6.17E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.58|P-value:1.69E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.02|P-value:2.41E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.76|P-value:6.92E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.80|P-value:5.58E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.76|P-value:8.05E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.72|P-value:8.21E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.96|P-value:2.28E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:2.71|P-value:8.38E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.11|P-value:1.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.83|P-value:5.62E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.65|P-value:1.46E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-2.80|P-value:6.87E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-2.70|P-value:9.91E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.53|P-value:2.58E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.23|P-value:9.19E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.25|P-value:1.01E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.86|P-value:5.37E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.24|P-value:1.05E-4 ID:SGTC_2403|Compound:6032726|FD-Score:5.01|P-value:3.48E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.94|P-value:3.91E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.07|P-value:1.91E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.94|P-value:3.33E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.02|P-value:2.36E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.52|P-value:2.28E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-2.74|P-value:8.53E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.85|P-value:4.74E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.02|P-value:2.33E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.86|P-value:4.66E-4 ID:SGTC_3096|Compound:9117468|FD-Score:4.06|P-value:1.34E-6 ID:SGTC_3210|Compound:9128157|FD-Score:2.87|P-value:4.52E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.82|P-value:5.50E-4 ID:SGTC_3269|Compound:9137823|FD-Score:2.86|P-value:4.72E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.72|P-value:8.24E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:2.81|P-value:5.74E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.89|P-value:3.49E-6 ID:SGTC_291|Compound:4130-1278|FD-Score:3.01|P-value:2.43E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.26|P-value:7.94E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-2.82|P-value:6.17E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.58|P-value:1.69E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.02|P-value:2.41E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.76|P-value:6.92E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.80|P-value:5.58E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.76|P-value:8.05E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.72|P-value:8.21E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-2.84|P-value:5.69E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.96|P-value:2.28E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:2.71|P-value:8.38E-4 ID:SGTC_1661|Compound:st013063|FD-Score:3.11|P-value:1.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.83|P-value:5.62E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.65|P-value:1.46E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-2.80|P-value:6.87E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-2.70|P-value:9.91E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.53|P-value:2.58E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.23|P-value:9.19E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.25|P-value:1.01E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-2.86|P-value:5.37E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.24|P-value:1.05E-4 ID:SGTC_2403|Compound:6032726|FD-Score:5.01|P-value:3.48E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.94|P-value:3.91E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.07|P-value:1.91E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.94|P-value:3.33E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.02|P-value:2.36E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.52|P-value:2.28E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-2.74|P-value:8.53E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.85|P-value:4.74E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.02|P-value:2.33E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.86|P-value:4.66E-4 ID:SGTC_3096|Compound:9117468|FD-Score:4.06|P-value:1.34E-6 ID:SGTC_3210|Compound:9128157|FD-Score:2.87|P-value:4.52E-4 ID:SGTC_3265|Compound:9137266|FD-Score:2.82|P-value:5.50E-4 ID:SGTC_3269|Compound:9137823|FD-Score:2.86|P-value:4.72E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.72|P-value:8.24E-4

Top fitness defect scores for YKR012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2403 6032726 5.01 181.2 µM 3.48E-9 17 2.66E-7
2 SGTC_3096 9117468 4.06 49.5 µM 1.34E-6 3 2.45E-5
3 SGTC_1521 st012942 3.96 49.4 µM 2.28E-6 32 3.68E-5
4 SGTC_234 nsc-17383 3.89 10.7 µM 3.49E-6 ERG2 24 5.08E-5
5 SGTC_1156 4092-0367 3.80 4.9 µM 5.58E-6 26 7.25E-5
6 SGTC_795 0685-0265 3.58 78.0 µM 1.69E-5 excess fatty acid 35 1.69E-4
7 SGTC_2697 mebhydrolin 3.52 72.4 µM 2.28E-5 NEO1 89 2.12E-4
8 SGTC_360 0957-0399 3.26 1.0 µM 7.94E-5 cell wall 77 5.50E-4
9 SGTC_1989 st071868 3.23 50.2 µM 9.19E-5 31 6.15E-4
10 SGTC_1661 st013063 3.11 9.7 µM 1.58E-4 54 9.29E-4
11 SGTC_2575 plumbagin 3.07 510.0 nM 1.91E-4 superoxide 81 0.00108
12 SGTC_3038 9091290 3.02 49.5 µM 2.33E-4 54 0.00125
13 SGTC_2591 skatole 3.02 100.0 µM 2.36E-4 63 0.00126
14 SGTC_824 1304-0008 3.02 100.0 µM 2.41E-4 DNA damage response 85 0.00128
15 SGTC_291 4130-1278 3.01 35.5 µM 2.43E-4 Golgi 46 0.00129
16 SGTC_2588 indole-3-carbinol 2.94 100.0 µM 3.33E-4 112 0.00165
17 SGTC_3210 9128157 2.87 49.5 µM 4.52E-4 116 0.00208
18 SGTC_3081 9117243 2.86 49.5 µM 4.66E-4 fatty acid desaturase (OLE1) 63 0.00213
19 SGTC_3269 9137823 2.86 49.5 µM 4.72E-4 60S ribosome export 62 0.00215
20 SGTC_3018 9082602 2.85 49.5 µM 4.74E-4 86 0.00216

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 6.85E-19 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.121 2.09E-12 YMR153C-A_d YMR153C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
0.117 9.21E-12 YPL261C_d YPL261C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
0.112 6.60E-11 YLR399C BDF1 hom Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
0.106 7.92E-10 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.105 8.98E-10 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
0.103 2.19E-9 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.097 1.63E-8 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.094 4.30E-8 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.092 1.00E-7 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.091 1.14E-7 YPL273W SAM4 hom S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.091 1.38E-7 YLR392C ART10 hom Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
0.090 1.75E-7 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.088 3.44E-7 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication
0.085 7.26E-7 YJL161W_p FMP33_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies