YKR015C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR015C / YKR015C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.71|P-value:1.62E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.13|P-value:2.26E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.05|P-value:3.06E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.88|P-value:6.33E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:2.89|P-value:6.00E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.99|P-value:3.97E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.67|P-value:1.93E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.75|P-value:1.34E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.16|P-value:1.93E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:2.99|P-value:4.05E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.92|P-value:5.30E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:2.88|P-value:6.26E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.82|P-value:7.88E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:2.28E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.45|P-value:5.56E-5 ID:SGTC_1813|Compound:st051246|FD-Score:4.16|P-value:1.57E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.16|P-value:1.96E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.24|P-value:1.43E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.86|P-value:6.69E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.41|P-value:6.71E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-2.78|P-value:8.90E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.22|P-value:1.45E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.80|P-value:8.63E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.54|P-value:3.58E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.80|P-value:8.57E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-2.78|P-value:8.91E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.93|P-value:4.87E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.63|P-value:2.31E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-2.93|P-value:4.98E-4 ID:SGTC_2964|Compound:9083345|FD-Score:2.95|P-value:4.79E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.04|P-value:3.13E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.93|P-value:4.83E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.35|P-value:8.49E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.08|P-value:2.62E-4 ID:SGTC_3232|Compound:9132874|FD-Score:2.77|P-value:9.57E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.71|P-value:1.62E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.13|P-value:2.26E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.05|P-value:3.06E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.88|P-value:6.33E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:2.89|P-value:6.00E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.99|P-value:3.97E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.67|P-value:1.93E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.75|P-value:1.34E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.16|P-value:1.93E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:2.99|P-value:4.05E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:2.92|P-value:5.30E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:2.88|P-value:6.26E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.13|P-value:2.22E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.82|P-value:7.88E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:2.28E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.45|P-value:5.56E-5 ID:SGTC_1813|Compound:st051246|FD-Score:4.16|P-value:1.57E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.16|P-value:1.96E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.24|P-value:1.43E-4 ID:SGTC_2099|Compound:5377090|FD-Score:2.86|P-value:6.69E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.41|P-value:6.71E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-2.78|P-value:8.90E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.22|P-value:1.45E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.80|P-value:8.63E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.54|P-value:3.58E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.80|P-value:8.57E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-2.78|P-value:8.91E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-2.93|P-value:4.87E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.63|P-value:2.31E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-2.93|P-value:4.98E-4 ID:SGTC_2964|Compound:9083345|FD-Score:2.95|P-value:4.79E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.04|P-value:3.13E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.93|P-value:4.83E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.35|P-value:8.49E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.08|P-value:2.62E-4 ID:SGTC_3232|Compound:9132874|FD-Score:2.77|P-value:9.57E-4

Top fitness defect scores for YKR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1813 st051246 4.16 8.6 µM 1.57E-6 TSC3-RPN4 11 1.62E-5
2 SGTC_513 4245-1575 3.75 41.7 µM 1.34E-5 unfolded protein response 124 9.00E-5
3 SGTC_69 0096-0274 3.71 206.7 µM 1.62E-5 mitochondrial processes 52 1.05E-4
4 SGTC_414 piperonyl butoxide 3.67 100.0 µM 1.93E-5 17 1.21E-4
5 SGTC_1713 st033146 3.64 12.8 µM 2.28E-5 36 1.38E-4
6 SGTC_2824 7998404 3.63 52.0 µM 2.31E-5 41 1.40E-4
7 SGTC_2601 securinine 3.54 100.0 µM 3.58E-5 40 1.99E-4
8 SGTC_1810 st050138 3.45 53.0 µM 5.56E-5 PDR1 21 2.83E-4
9 SGTC_2170 morpholine 3.41 200.0 µM 6.71E-5 26 3.30E-4
10 SGTC_3143 9086658 3.35 49.5 µM 8.49E-5 75 3.98E-4
11 SGTC_1840 st055363 3.24 71.0 µM 1.43E-4 38 6.08E-4
12 SGTC_3124 9127567 3.22 49.5 µM 1.54E-4 DNA damage response 39 6.43E-4
13 SGTC_1829 berberine 3.16 14.4 µM 1.96E-4 60S ribosome export 42 7.81E-4
14 SGTC_1447 4239-0816 3.13 81.9 µM 2.22E-4 68 8.64E-4
15 SGTC_99 0109-0120 3.13 622.8 µM 2.26E-4 42 8.76E-4
16 SGTC_411 enrofloxacin 2.99 100.0 µM 3.97E-4 DNA damage response 30 0.00138
17 SGTC_733 4069-0007 2.99 56.1 µM 4.05E-4 ERAD & cell cycle 148 0.00141
18 SGTC_2964 9083345 2.95 53.4 µM 4.79E-4 65 0.00161
19 SGTC_810 3825-7150 2.92 143.0 µM 5.30E-4 60S ribosome export 40 0.00174
20 SGTC_300 r073-0011 2.89 5.0 µM 6.00E-4 70 0.00193

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.88E-15 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.120 4.08E-12 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.119 3.93E-12 YDR353W TRR1 het Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
0.117 9.69E-12 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.108 3.64E-10 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.106 8.44E-10 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.104 1.52E-9 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.103 2.24E-9 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.103 2.66E-9 YNL012W SPO1 hom Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
0.102 3.39E-9 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.101 4.21E-9 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.100 5.65E-9 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.099 8.70E-9 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.096 3.02E-8 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.094 5.46E-8 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis