YKR023W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR023W / YKR023W

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-2.97|P-value:9.39E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.02|P-value:8.07E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:4.15|P-value:1.64E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.06|P-value:6.86E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.74|P-value:1.30E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.11|P-value:2.15E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.48|P-value:1.26E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.95|P-value:4.03E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.13|P-value:5.16E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.39|P-value:6.63E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.16|P-value:5.41E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.07|P-value:1.93E-14 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.04|P-value:7.31E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.93|P-value:4.37E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.95|P-value:4.06E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.13|P-value:1.99E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.15|P-value:4.82E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.84|P-value:2.51E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.91|P-value:1.87E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.27|P-value:2.99E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.47|P-value:1.29E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.48|P-value:1.01E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.90|P-value:5.05E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.25|P-value:1.19E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.84|P-value:6.28E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.98|P-value:3.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.10|P-value:2.24E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.94|P-value:4.21E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.02|P-value:3.22E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-3.37|P-value:2.03E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.31|P-value:2.55E-6 ID:SGTC_2886|Compound:9058944|FD-Score:2.90|P-value:5.04E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.06|P-value:2.66E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.97|P-value:9.52E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.20|P-value:1.48E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-2.97|P-value:9.39E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.02|P-value:8.07E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:4.15|P-value:1.64E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-3.06|P-value:6.86E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.74|P-value:1.30E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.11|P-value:2.15E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.48|P-value:1.26E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:2.95|P-value:4.03E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.13|P-value:5.16E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.39|P-value:6.63E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.16|P-value:5.41E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.07|P-value:1.93E-14 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.04|P-value:7.31E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.93|P-value:4.37E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.95|P-value:4.06E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.13|P-value:1.99E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.15|P-value:4.82E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.84|P-value:2.51E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.91|P-value:1.87E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.27|P-value:2.99E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.47|P-value:1.29E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-4.48|P-value:1.01E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.90|P-value:5.05E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.25|P-value:1.19E-4 ID:SGTC_2004|Compound:4023728|FD-Score:2.84|P-value:6.28E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.98|P-value:3.61E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.10|P-value:2.24E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.94|P-value:4.21E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.02|P-value:3.22E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-3.37|P-value:2.03E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.39|P-value:1.85E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.31|P-value:2.55E-6 ID:SGTC_2886|Compound:9058944|FD-Score:2.90|P-value:5.04E-4 ID:SGTC_2891|Compound:9063876|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.06|P-value:2.66E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-2.97|P-value:9.52E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.20|P-value:1.48E-4

Top fitness defect scores for YKR023W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_185 k048-0037 4.15 25.5 µM 1.64E-6 RSC & ERG11 9 1.68E-5
2 SGTC_2829 7992743 4.02 58.4 µM 3.22E-6 34 2.93E-5
3 SGTC_321 4534-3890 3.74 65.3 µM 1.30E-5 RPP1 & pyrimidine depletion 6 9.28E-5
4 SGTC_632 0781-2353 3.39 4.7 µM 6.63E-5 Golgi 67 3.55E-4
5 SGTC_1996 st072960 3.25 66.8 µM 1.19E-4 44 5.74E-4
6 SGTC_3018 9082602 3.20 49.5 µM 1.48E-4 69 6.88E-4
7 SGTC_1561 5-methoxyflavone 3.13 52.9 µM 1.99E-4 17 8.77E-4
8 SGTC_378 3970-0959 3.11 8.3 µM 2.15E-4 43 9.37E-4
9 SGTC_2125 5246583 3.10 200.0 µM 2.24E-4 tubulin folding & SWR complex 93 9.67E-4
10 SGTC_2898 9056270 3.06 58.4 µM 2.66E-4 21 0.00111
11 SGTC_2103 5378138 2.98 10.0 µM 3.61E-4 60 0.00143
12 SGTC_2891 9063876 2.96 19.5 µM 3.90E-4 27 0.00153
13 SGTC_522 1273-0010 2.95 11.6 µM 4.03E-4 60S ribosome export 62 0.00157
14 SGTC_1379 2144-0755 2.95 36.5 µM 4.06E-4 66 0.00158
15 SGTC_2309 7664088 2.94 163.9 µM 4.21E-4 111 0.00163
16 SGTC_1332 1480-0653 2.93 17.5 µM 4.37E-4 TSC3-RPN4 56 0.00168
17 SGTC_2886 9058944 2.90 52.0 µM 5.04E-4 13 0.00189
18 SGTC_1988 st071872 2.90 53.4 µM 5.05E-4 50 0.00189
19 SGTC_189 3970-0742 2.87 2.1 µM 5.49E-4 31 0.00203
20 SGTC_2004 4023728 2.84 41.9 µM 6.28E-4 90 0.00226

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.268 1.84E-56 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.263 2.18E-54 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.255 4.67E-51 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.243 3.89E-46 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.242 9.81E-46 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.238 1.94E-44 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.234 3.76E-43 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.222 7.47E-39 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.217 5.94E-37 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.214 4.25E-36 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.211 5.57E-35 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.209 1.40E-34 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.209 1.83E-34 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.209 2.53E-34 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208 4.65E-34 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p