YKR029C / SET3

Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR029C / SET3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.32|P-value:5.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.19|P-value:1.85E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.51|P-value:3.38E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.69|P-value:2.15E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.54|P-value:2.66E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.49|P-value:3.13E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:2.59E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.32|P-value:1.14E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.36|P-value:4.93E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.46|P-value:3.54E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.62|P-value:1.87E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.69|P-value:2.21E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.61|P-value:1.96E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.32|P-value:5.80E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.08|P-value:3.21E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.80|P-value:1.00E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-7.32|P-value:3.65E-13 ID:SGTC_1396|Compound:3511-0007|FD-Score:-7.11|P-value:1.63E-12 ID:SGTC_1397|Compound:3532-0190|FD-Score:-5.91|P-value:3.51E-9 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.92|P-value:6.09E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:7.07|P-value:2.14E-12 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.34|P-value:5.45E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.23|P-value:7.87E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.64|P-value:2.73E-6 ID:SGTC_1571|Compound:st070080|FD-Score:-3.38|P-value:4.74E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.91|P-value:6.40E-12 ID:SGTC_1687|Compound:st020778|FD-Score:4.12|P-value:2.78E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.26|P-value:7.13E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.36|P-value:9.58E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.84|P-value:8.60E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.55|P-value:2.49E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.06|P-value:3.57E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.42|P-value:7.46E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-3.28|P-value:6.54E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.19|P-value:8.84E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.27|P-value:6.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.40|P-value:1.83E-29 ID:SGTC_2625|Compound:euphol|FD-Score:5.05|P-value:3.84E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.07|P-value:3.39E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.80|P-value:9.88E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.04|P-value:3.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.64|P-value:2.80E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-4.83|P-value:1.12E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.12|P-value:2.72E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:4.78E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.21|P-value:8.42E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.52|P-value:2.84E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.43|P-value:3.90E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.32|P-value:5.68E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.32|P-value:5.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.19|P-value:1.85E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:3.87E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:5.51|P-value:3.38E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.69|P-value:2.15E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.54|P-value:2.66E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.49|P-value:3.13E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.54|P-value:2.59E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.32|P-value:1.14E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.36|P-value:4.93E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.51|P-value:2.98E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.46|P-value:3.54E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.62|P-value:1.87E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.69|P-value:2.21E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.61|P-value:1.96E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.32|P-value:5.80E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.08|P-value:3.21E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.80|P-value:1.00E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-7.32|P-value:3.65E-13 ID:SGTC_1396|Compound:3511-0007|FD-Score:-7.11|P-value:1.63E-12 ID:SGTC_1397|Compound:3532-0190|FD-Score:-5.91|P-value:3.51E-9 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.92|P-value:6.09E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:7.07|P-value:2.14E-12 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.34|P-value:5.45E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.23|P-value:7.87E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.64|P-value:2.73E-6 ID:SGTC_1571|Compound:st070080|FD-Score:-3.38|P-value:4.74E-4 ID:SGTC_1630|Compound:st005209|FD-Score:6.91|P-value:6.40E-12 ID:SGTC_1687|Compound:st020778|FD-Score:4.12|P-value:2.78E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.26|P-value:7.13E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.36|P-value:9.58E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.84|P-value:8.60E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.55|P-value:2.49E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.17|P-value:2.22E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.06|P-value:3.57E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.42|P-value:7.46E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-3.28|P-value:6.54E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.19|P-value:8.84E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.90E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.27|P-value:6.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.40|P-value:1.83E-29 ID:SGTC_2625|Compound:euphol|FD-Score:5.05|P-value:3.84E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.07|P-value:3.39E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.80|P-value:9.88E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.04|P-value:3.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.30|P-value:1.27E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.64|P-value:2.80E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-4.83|P-value:1.12E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.12|P-value:2.72E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.41|P-value:4.23E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.37|P-value:4.78E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.21|P-value:8.42E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.52|P-value:2.84E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.34|P-value:5.38E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.43|P-value:3.90E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.32|P-value:5.68E-4

Top fitness defect scores for YKR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 11.40 100.0 µM 1.83E-29 redox potentiating 46 1.22E-30
2 SGTC_1401 3807-4679 7.07 7.6 µM 2.14E-12 tubulin folding & SWR complex 4 7.51E-13
3 SGTC_1630 st005209 6.91 31.3 µM 6.40E-12 1 2.35E-12
4 SGTC_955 1216-0110 5.62 33.0 µM 1.87E-8 sphingolipid biosynthesis & PDR1 37 9.61E-9
5 SGTC_1317 1273-0028 5.61 910.0 nM 1.96E-8 azole & statin 30 1.01E-8
6 SGTC_86 0417-1630 5.51 471.9 µM 3.38E-8 ubiquinone biosynthesis & proteasome 97 1.78E-8
7 SGTC_58 0957-0393 5.19 9.0 µM 1.85E-7 cell wall 263 1.04E-7
8 SGTC_1389 3405-0187 5.08 19.0 µM 3.21E-7 6 1.85E-7
9 SGTC_2625 euphol 5.05 100.0 µM 3.84E-7 13 2.23E-7
10 SGTC_158 k038-0087 4.69 26.4 µM 2.15E-6 ubiquinone biosynthesis & proteasome 99 1.34E-6
11 SGTC_1511 0906-3109 4.64 28.5 µM 2.73E-6 excess fatty acid 24 1.72E-6
12 SGTC_2752 diclazuril 4.64 33.1 µM 2.80E-6 86 1.77E-6
13 SGTC_2004 4023728 4.42 41.9 µM 7.46E-6 18 4.90E-6
14 SGTC_1718 roemerine 4.36 11.9 µM 9.58E-6 redox potentiating 39 6.36E-6
15 SGTC_528 3492-0019 4.32 172.0 µM 1.14E-5 calcium & mitochondrial duress 190 7.63E-6
16 SGTC_2679 rapamycin 4.30 1.0 nM 1.27E-5 126 8.55E-6
17 SGTC_1934 st074720 4.17 32.6 µM 2.22E-5 47 1.52E-5
18 SGTC_1006 4099-6547 4.12 255.0 µM 2.68E-5 16 1.86E-5
19 SGTC_1687 st020778 4.12 55.4 µM 2.78E-5 168 1.93E-5
20 SGTC_1941 st076221 4.06 61.8 µM 3.57E-5 sphingolipid biosynthesis & PDR1 76 2.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 8.23E-100 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.293 1.80E-67 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.269 1.47E-56 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.258 4.29E-52 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.251 3.34E-49 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.245 6.01E-47 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.233 1.68E-42 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.231 8.53E-42 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.215 3.12E-36 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.210 1.12E-34 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.205 4.20E-33 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.205 4.06E-33 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.205 4.64E-33 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.200 1.05E-31 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.196 2.07E-30 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants