YKR033C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR033C / YKR033C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.93|P-value:4.50E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.17|P-value:8.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:9.66E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:5.59|P-value:1.31E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.26|P-value:5.93E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.98|P-value:3.68E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.13|P-value:9.01E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.11|P-value:2.06E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.37|P-value:3.86E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.37|P-value:4.08E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-4.21|P-value:1.41E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:2.63E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.26|P-value:5.80E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.28|P-value:5.55E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.57|P-value:2.66E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.15|P-value:8.47E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.10|P-value:2.28E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.89|P-value:5.62E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-4.25|P-value:1.19E-5 ID:SGTC_1663|Compound:st014140|FD-Score:-3.20|P-value:7.24E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.37|P-value:3.85E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.18|P-value:1.60E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.05|P-value:2.76E-5 ID:SGTC_1795|Compound:st049545|FD-Score:6.25|P-value:2.36E-10 ID:SGTC_1852|Compound:st056254|FD-Score:3.77|P-value:8.73E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.24|P-value:6.28E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-4.19|P-value:1.51E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-4.82|P-value:8.21E-7 ID:SGTC_2294|Compound:7971431|FD-Score:-3.11|P-value:9.77E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.37|P-value:6.69E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.75|P-value:1.12E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.98|P-value:3.59E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.29|P-value:5.39E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-5.48|P-value:2.42E-8 ID:SGTC_3062|Compound:9077494|FD-Score:-3.67|P-value:1.31E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.33|P-value:4.63E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.07|P-value:2.47E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.93|P-value:4.50E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.17|P-value:8.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:9.66E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:5.59|P-value:1.31E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.26|P-value:5.93E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.98|P-value:3.68E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.13|P-value:9.01E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.11|P-value:2.06E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.37|P-value:3.86E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.37|P-value:4.08E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-4.21|P-value:1.41E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.48|P-value:2.63E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.40|P-value:3.64E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.26|P-value:5.80E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.41|P-value:3.34E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:-3.28|P-value:5.55E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.57|P-value:2.66E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.15|P-value:8.47E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-4.10|P-value:2.28E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.89|P-value:5.62E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-4.25|P-value:1.19E-5 ID:SGTC_1663|Compound:st014140|FD-Score:-3.20|P-value:7.24E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.37|P-value:3.85E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-4.18|P-value:1.60E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.05|P-value:2.76E-5 ID:SGTC_1795|Compound:st049545|FD-Score:6.25|P-value:2.36E-10 ID:SGTC_1852|Compound:st056254|FD-Score:3.77|P-value:8.73E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.24|P-value:6.28E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-4.19|P-value:1.51E-5 ID:SGTC_2266|Compound:7929956|FD-Score:-4.82|P-value:8.21E-7 ID:SGTC_2294|Compound:7971431|FD-Score:-3.11|P-value:9.77E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.37|P-value:6.69E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.75|P-value:1.12E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.98|P-value:3.59E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-3.29|P-value:5.39E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-5.48|P-value:2.42E-8 ID:SGTC_3062|Compound:9077494|FD-Score:-3.67|P-value:1.31E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.33|P-value:4.63E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.07|P-value:2.47E-5

Top fitness defect scores for YKR033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1795 st049545 6.25 62.3 µM 2.36E-10 TSC3-RPN4 3 2.04E-10
2 SGTC_453 enantio-paf c16 6.03 10.0 µM 9.66E-10 46 8.41E-10
3 SGTC_455 paf C-16 5.59 10.0 µM 1.31E-8 12 1.16E-8
4 SGTC_1364 1653-0028 4.89 37.6 µM 5.62E-7 8 5.15E-7
5 SGTC_2416 tofa 4.75 880.0 nM 1.12E-6 sphingolipid biosynthesis & PDR1 32 1.03E-6
6 SGTC_1339 1486-1321 4.57 22.7 µM 2.66E-6 ERG2 9 2.47E-6
7 SGTC_2371 9071574 4.37 200.0 µM 6.69E-6 8 6.24E-6
8 SGTC_781 4335-2806 4.11 94.4 µM 2.06E-5 15 1.94E-5
9 SGTC_3290 9121031 4.07 71.4 µM 2.47E-5 9 2.32E-5
10 SGTC_1779 st039427 4.05 55.0 µM 2.76E-5 25 2.60E-5
11 SGTC_1320 1313-0481 4.00 95.3 µM 3.40E-5 20 3.21E-5
12 SGTC_2636 apigenin dimethyl ether 3.98 100.0 µM 3.59E-5 48 3.39E-5
13 SGTC_757 1066-0008 3.98 322.0 µM 3.68E-5 Golgi 17 3.47E-5
14 SGTC_6 0844-0013 3.93 19.8 µM 4.50E-5 91 4.25E-5
15 SGTC_1852 st056254 3.77 31.4 µM 8.73E-5 12 8.30E-5
16 SGTC_2415 st077333 3.76 57.7 µM 8.80E-5 51 8.37E-5
17 SGTC_1074 carmofur 3.48 3.8 µM 2.63E-4 exosome 40 2.52E-4
18 SGTC_1209 2323-2347 3.41 50.3 µM 3.34E-4 26 3.21E-4
19 SGTC_1721 st082152 3.37 9.3 µM 3.85E-4 60S ribosome export 39 3.70E-4
20 SGTC_944 3370-0224 3.37 231.0 µM 3.86E-4 50 3.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 8.68E-21 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.159 1.67E-20 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 1.16E-15 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.137 1.75E-15 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.124 5.60E-13 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.119 4.45E-12 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.119 5.36E-12 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.118 6.54E-12 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.116 1.59E-11 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.112 8.60E-11 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.111 1.33E-10 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.108 3.37E-10 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.102 2.76E-9 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.102 3.01E-9 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.101 5.22E-9 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins