YKR041W

Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR041W / YKR041W

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:2.89|P-value:7.23E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.02|P-value:4.28E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.37|P-value:9.98E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.02|P-value:4.02E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-2.89|P-value:6.72E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.31|P-value:8.92E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:2.82|P-value:9.28E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.24|P-value:1.77E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.75|P-value:7.84E-8 ID:SGTC_1018|Compound:4259-0013|FD-Score:-4.01|P-value:4.39E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.82|P-value:1.13E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.90|P-value:7.02E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-5.02|P-value:1.32E-8 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.75|P-value:1.78E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.54|P-value:4.40E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.81|P-value:1.23E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.46|P-value:6.86E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.04|P-value:4.10E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.10|P-value:2.91E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.42|P-value:8.13E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.18|P-value:2.10E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.59|P-value:3.50E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.94|P-value:5.57E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.07|P-value:3.25E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.92|P-value:6.54E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.05|P-value:3.88E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.02|P-value:4.40E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.55|P-value:4.42E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.16|P-value:2.50E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.84|P-value:8.06E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-2.98|P-value:4.73E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.05|P-value:3.91E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.16|P-value:2.52E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.05|P-value:3.88E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.25|P-value:1.72E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.02|P-value:4.43E-4 ID:SGTC_2840|Compound:9008771|FD-Score:2.96|P-value:5.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.86|P-value:3.98E-8 ID:SGTC_2908|Compound:7930301|FD-Score:-4.73|P-value:7.86E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.28|P-value:1.52E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.06|P-value:3.74E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.64|P-value:2.97E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:2.89|P-value:7.23E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.02|P-value:4.28E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.37|P-value:9.98E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.02|P-value:4.02E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-2.89|P-value:6.72E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.31|P-value:8.92E-7 ID:SGTC_949|Compound:1165-0505|FD-Score:2.82|P-value:9.28E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.24|P-value:1.77E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.75|P-value:7.84E-8 ID:SGTC_1018|Compound:4259-0013|FD-Score:-4.01|P-value:4.39E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.82|P-value:1.13E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.90|P-value:7.02E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-5.02|P-value:1.32E-8 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.75|P-value:1.78E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.54|P-value:4.40E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.81|P-value:1.23E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.46|P-value:6.86E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.04|P-value:4.10E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.10|P-value:2.91E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.42|P-value:8.13E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.18|P-value:2.10E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.59|P-value:3.50E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.94|P-value:5.57E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.07|P-value:3.25E-4 ID:SGTC_1987|Compound:st072290|FD-Score:2.92|P-value:6.54E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.05|P-value:3.88E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.02|P-value:4.40E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.55|P-value:4.42E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.16|P-value:2.50E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-2.84|P-value:8.06E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-2.98|P-value:4.73E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.05|P-value:3.91E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.16|P-value:2.52E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.05|P-value:3.88E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.25|P-value:1.72E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.02|P-value:4.43E-4 ID:SGTC_2840|Compound:9008771|FD-Score:2.96|P-value:5.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.86|P-value:3.98E-8 ID:SGTC_2908|Compound:7930301|FD-Score:-4.73|P-value:7.86E-8 ID:SGTC_2933|Compound:9026794|FD-Score:3.28|P-value:1.52E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.06|P-value:3.74E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.64|P-value:2.97E-5

Top fitness defect scores for YKR041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2902 5787006 4.86 60.5 µM 3.98E-8 Golgi 13 5.75E-7
2 SGTC_1012 4112-3522 4.75 18.0 µM 7.84E-8 13 1.01E-6
3 SGTC_1370 2001-0092 4.04 44.6 µM 4.10E-6 30 2.64E-5
4 SGTC_1254 0550-0035 3.75 264.0 µM 1.78E-5 27 8.90E-5
5 SGTC_3055 9094636 3.64 49.5 µM 2.97E-5 16 1.36E-4
6 SGTC_2384 9036245 3.55 200.0 µM 4.42E-5 43 1.89E-4
7 SGTC_1296 1068-0102 3.46 11.9 µM 6.86E-5 16 2.72E-4
8 SGTC_1455 4262-0120 3.42 131.0 µM 8.13E-5 plasma membrane duress 43 3.14E-4
9 SGTC_394 menadione 3.37 8.3 µM 9.98E-5 superoxide 53 3.72E-4
10 SGTC_2933 9026794 3.28 32.5 µM 1.52E-4 58 5.27E-4
11 SGTC_2807 7945238 3.25 52.0 µM 1.72E-4 65 5.84E-4
12 SGTC_988 1497-1057 3.24 103.0 µM 1.77E-4 29 5.99E-4
13 SGTC_1568 digitonin 3.19 820.0 nM 2.14E-4 sphingolipid biosynthesis & PDR1 61 7.01E-4
14 SGTC_2426 5582046 3.16 32.2 µM 2.50E-4 60 7.96E-4
15 SGTC_2557 derrustone 3.16 83.8 µM 2.52E-4 74 8.02E-4
16 SGTC_3050 9093513 3.06 49.5 µM 3.74E-4 46 0.00111
17 SGTC_2327 6189656 3.05 200.0 µM 3.88E-4 55 0.00115
18 SGTC_2764 methyldopa 3.05 94.7 µM 3.88E-4 63 0.00115
19 SGTC_2551 apiole 3.05 73.9 µM 3.91E-4 28 0.00116
20 SGTC_153 4077-0274 3.02 519.7 µM 4.28E-4 50 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.09E-15 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.127 1.30E-13 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.126 2.44E-13 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.126 3.09E-13 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.123 9.77E-13 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.120 2.69E-12 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.113 5.31E-11 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.112 9.57E-11 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.17E-10 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.109 2.35E-10 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.105 1.25E-9 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.101 4.35E-9 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.098 1.10E-8 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.097 1.94E-8 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.096 2.39E-8 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress