YKR044W / UIP5

Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR044W / UIP5

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.34|P-value:2.35E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:4.28E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-5.04|P-value:6.45E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.86|P-value:1.80E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.61|P-value:6.89E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.23|P-value:4.77E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.41|P-value:1.78E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.67|P-value:5.17E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:2.99|P-value:8.80E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.49|P-value:1.29E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.63|P-value:7.25E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.99|P-value:1.44E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.64|P-value:6.99E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.34|P-value:2.35E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.07|P-value:6.37E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.97|P-value:9.28E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.17|P-value:4.60E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.72|P-value:4.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.09|P-value:6.11E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.31|P-value:2.63E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.04|P-value:7.21E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-2.97|P-value:9.38E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.32|P-value:2.93E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.89|P-value:2.27E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.21|P-value:5.07E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.04|P-value:7.25E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.20|P-value:5.32E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.38|P-value:1.99E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.50|P-value:4.19E-9 ID:SGTC_2829|Compound:7992743|FD-Score:2.99|P-value:8.63E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.19|P-value:4.12E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.70|P-value:5.36E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.14|P-value:5.06E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.20|P-value:4.07E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.34|P-value:2.35E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:4.28E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.55|P-value:1.01E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-5.04|P-value:6.45E-8 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.86|P-value:1.80E-7 ID:SGTC_996|Compound:3970-0799|FD-Score:-4.61|P-value:6.89E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.23|P-value:4.77E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.41|P-value:1.78E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.67|P-value:5.17E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:2.99|P-value:8.80E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.49|P-value:1.29E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.63|P-value:7.25E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.99|P-value:1.44E-5 ID:SGTC_1849|Compound:st056239|FD-Score:3.64|P-value:6.99E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.34|P-value:2.35E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.07|P-value:6.37E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-3.14|P-value:5.03E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.97|P-value:9.28E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.17|P-value:4.60E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.72|P-value:4.82E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.09|P-value:6.11E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.31|P-value:2.63E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.04|P-value:7.21E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-2.97|P-value:9.38E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.32|P-value:2.93E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.89|P-value:2.27E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.21|P-value:5.07E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.40|P-value:1.84E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.04|P-value:7.25E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.20|P-value:5.32E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.38|P-value:1.99E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-5.50|P-value:4.19E-9 ID:SGTC_2829|Compound:7992743|FD-Score:2.99|P-value:8.63E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.19|P-value:4.12E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.70|P-value:5.36E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.14|P-value:5.06E-4

Top fitness defect scores for YKR044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1133 3473-0247 4.67 50.0 µM 5.17E-7 RSC complex & mRNA processing 29 1.54E-6
2 SGTC_1030 k029-0042 4.23 36.7 µM 4.77E-6 TSC3-RPN4 20 1.18E-5
3 SGTC_2584 androsterone 3.89 48.7 µM 2.27E-5 cell wall 135 4.91E-5
4 SGTC_2329 6138490 3.72 200.0 µM 4.82E-5 40 9.79E-5
5 SGTC_1849 st056239 3.64 19.2 µM 6.99E-5 RPP1 & pyrimidine depletion 35 1.38E-4
6 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.63 90.6 µM 7.25E-5 48 1.42E-4
7 SGTC_915 methyl methanesulfonate (MMS) 3.55 110.0 mM 1.01E-4 DNA damage response 57 1.92E-4
8 SGTC_1948 st076329 3.34 66.6 µM 2.35E-4 50 4.18E-4
9 SGTC_564 3555-0129 3.34 330.0 µM 2.35E-4 17 4.19E-4
10 SGTC_2333 9017922 3.31 200.0 µM 2.63E-4 51 4.64E-4
11 SGTC_179 1273-0063 3.20 6.8 µM 4.07E-4 43 6.93E-4
12 SGTC_3017 9080681 3.19 49.5 µM 4.12E-4 36 7.00E-4
13 SGTC_784 4579-0127 3.18 173.0 µM 4.28E-4 52 7.26E-4
14 SGTC_2205 7238770 3.17 200.0 µM 4.60E-4 17 7.74E-4
15 SGTC_3308 9128332 3.14 17.6 µM 5.06E-4 plasma membrane duress 127 8.45E-4
16 SGTC_606 k015-0008 3.14 38.6 µM 5.10E-4 45 8.52E-4
17 SGTC_2330 7979373 3.09 200.0 µM 6.11E-4 60S ribosome export 73 0.00100
18 SGTC_2435 5706476 3.04 10.6 µM 7.21E-4 65 0.00117
19 SGTC_2667 digitoxin 3.04 100.0 µM 7.25E-4 20 0.00118
20 SGTC_2829 7992743 2.99 58.4 µM 8.63E-4 91 0.00138

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.94E-12 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.118 5.81E-12 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.105 9.84E-10 YOL047C_p YOL047C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.105 1.15E-9 YGL060W YBP2 hom Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
0.104 1.81E-9 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.103 2.05E-9 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.099 9.80E-9 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.096 2.64E-8 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 6.35E-8 YGR052W_p FMP48_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.092 9.66E-8 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.092 9.80E-8 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.092 1.08E-7 YDR468C TLG1 het Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
0.088 3.11E-7 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.087 3.90E-7 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.087 4.74E-7 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication