YKR078W

Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR078W / YKR078W

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.78|P-value:5.75E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.46|P-value:2.89E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.23|P-value:1.48E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.46|P-value:4.58E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.24|P-value:6.97E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.45|P-value:3.37E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.36|P-value:4.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.57|P-value:2.17E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:2.27E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.25|P-value:6.81E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:5.84E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.42|P-value:3.81E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.32|P-value:5.37E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.25|P-value:6.89E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.39|P-value:7.46E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-4.16|P-value:1.74E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.49|P-value:2.88E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.41|P-value:3.88E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.27|P-value:6.47E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.60|P-value:1.96E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.84|P-value:7.68E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.40|P-value:4.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.45|P-value:3.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.89|P-value:5.54E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.62|P-value:2.62E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.36|P-value:4.65E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.58|P-value:2.09E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.17|P-value:9.05E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.25|P-value:6.90E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.39|P-value:4.13E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.76|P-value:9.12E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-3.50|P-value:2.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.47|P-value:3.31E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.43|P-value:3.69E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.50|P-value:4.55E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.41|P-value:3.44E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.22|P-value:7.57E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.00|P-value:3.54E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.68|P-value:1.42E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.49|P-value:2.97E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.44|P-value:3.46E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.67|P-value:2.06E-6 ID:SGTC_2997|Compound:9067075|FD-Score:4.43|P-value:6.21E-6 ID:SGTC_2999|Compound:9069765|FD-Score:-4.50|P-value:3.97E-6 ID:SGTC_3001|Compound:9076041|FD-Score:4.01|P-value:3.87E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.37|P-value:4.48E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.15|P-value:9.72E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.53|P-value:3.97E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.27|P-value:6.45E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.54|P-value:2.15E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:9.60E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.49|P-value:2.55E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.38|P-value:3.89E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.32|P-value:4.84E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.42|P-value:3.32E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.39|P-value:4.23E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.78|P-value:5.75E-9 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.46|P-value:2.89E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.23|P-value:1.48E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.46|P-value:4.58E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.46|P-value:3.24E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.24|P-value:6.97E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.45|P-value:3.37E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.36|P-value:4.68E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.57|P-value:2.17E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:2.27E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.25|P-value:6.81E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:5.84E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.42|P-value:3.81E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.32|P-value:5.37E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.25|P-value:6.89E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.39|P-value:7.46E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.17|P-value:8.93E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-4.16|P-value:1.74E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.49|P-value:2.88E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.41|P-value:3.88E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.27|P-value:6.47E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.60|P-value:1.96E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.84|P-value:7.68E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.40|P-value:4.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.45|P-value:3.01E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.89|P-value:5.54E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.62|P-value:2.62E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.36|P-value:4.65E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.58|P-value:2.09E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.17|P-value:9.05E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.60|P-value:1.92E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.15|P-value:9.51E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.25|P-value:6.90E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.39|P-value:4.13E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.76|P-value:9.12E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-3.50|P-value:2.49E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.47|P-value:3.31E-8 ID:SGTC_2083|Compound:5306046|FD-Score:3.43|P-value:3.69E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.50|P-value:4.55E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.41|P-value:3.44E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.22|P-value:7.57E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.00|P-value:3.54E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.68|P-value:1.42E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.49|P-value:2.97E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.44|P-value:3.46E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.67|P-value:2.06E-6 ID:SGTC_2997|Compound:9067075|FD-Score:4.43|P-value:6.21E-6 ID:SGTC_2999|Compound:9069765|FD-Score:-4.50|P-value:3.97E-6 ID:SGTC_3001|Compound:9076041|FD-Score:4.01|P-value:3.87E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.37|P-value:4.48E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.15|P-value:9.72E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.53|P-value:3.97E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.27|P-value:6.45E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.54|P-value:2.15E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:9.60E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.49|P-value:2.55E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.38|P-value:3.89E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.32|P-value:4.84E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.42|P-value:3.32E-4

Top fitness defect scores for YKR078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_268 camptothecin 5.78 39.6 µM 5.75E-9 DNA damage response 34 3.71E-9
2 SGTC_1916 st067606 5.47 49.2 µM 3.31E-8 13 2.22E-8
3 SGTC_2989 9073649 4.67 71.4 µM 2.06E-6 18 1.52E-6
4 SGTC_1445 4239-0156 4.62 97.7 µM 2.62E-6 14 1.94E-6
5 SGTC_3011 9081274 4.53 71.4 µM 3.97E-6 5 2.97E-6
6 SGTC_2445 5742597 4.50 35.6 µM 4.55E-6 24 3.42E-6
7 SGTC_2997 9067075 4.43 71.4 µM 6.21E-6 unfolded protein response 42 4.69E-6
8 SGTC_1008 4106-0037 4.39 6.0 µM 7.46E-6 PDR1 16 5.67E-6
9 SGTC_1497 4476-2978 4.26 41.3 µM 1.31E-5 5 1.01E-5
10 SGTC_363 0455-0021 4.23 3.1 µM 1.48E-5 azole & statin 55 1.14E-5
11 SGTC_769 0302-0231 4.14 76.0 µM 2.27E-5 34 1.77E-5
12 SGTC_3001 9076041 4.01 71.4 µM 3.87E-5 14 3.05E-5
13 SGTC_1360 1598-0022 3.84 39.8 µM 7.68E-5 ERG2 33 6.16E-5
14 SGTC_1449 4112-4002 3.75 201.0 µM 1.08E-4 RPP1 & pyrimidine depletion 20 8.75E-5
15 SGTC_551 k048-0028 3.69 34.9 µM 1.38E-4 25 1.12E-4
16 SGTC_2765 myclobutanil 3.68 7.7 µM 1.42E-4 azole & statin 61 1.16E-4
17 SGTC_1644 st010134 3.60 20.9 µM 1.92E-4 mitochondrial processes 18 1.57E-4
18 SGTC_1356 1502-0781 3.60 85.8 µM 1.96E-4 fatty acid desaturase (OLE1) 25 1.61E-4
19 SGTC_1529 apigenin 3.58 74.0 µM 2.09E-4 42 1.72E-4
20 SGTC_766 1391-0721 3.57 126.0 µM 2.17E-4 24 1.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 4.09E-9 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.087 4.69E-7 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.086 6.24E-7 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.086 7.06E-7 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.02E-6 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.083 1.40E-6 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.082 2.27E-6 YGL104C VPS73 hom Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
0.081 2.88E-6 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.073 2.52E-5 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.071 3.76E-5 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.070 4.69E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.070 5.22E-5 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.068 8.55E-5 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.068 9.03E-5 YGR252W GCN5 hom Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
0.068 9.30E-5 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress