YKR096W / ESL2

Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR096W / ESL2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.31|P-value:1.54E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.54|P-value:5.82E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.29|P-value:7.36E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.33|P-value:1.42E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.40|P-value:5.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.90|P-value:6.10E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.41|P-value:5.06E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.36|P-value:5.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.45|P-value:4.20E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.01|P-value:5.34E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.03|P-value:4.85E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.37|P-value:5.70E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.79|P-value:1.24E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.84|P-value:1.03E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.38|P-value:1.21E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.95|P-value:9.02E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.41|P-value:1.01E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.25|P-value:8.35E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.41|P-value:4.96E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.23|P-value:8.87E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.63|P-value:3.85E-6 ID:SGTC_2304|Compound:7443016|FD-Score:3.48|P-value:3.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.49|P-value:3.80E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.60|P-value:4.55E-6 ID:SGTC_2424|Compound:5537928|FD-Score:4.18|P-value:2.63E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.49|P-value:3.74E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.26|P-value:8.09E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.34|P-value:1.36E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.14|P-value:3.35E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:4.31|P-value:1.54E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:4.54|P-value:5.82E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:3.29|P-value:7.36E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.33|P-value:1.42E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.40|P-value:5.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.90|P-value:6.10E-9 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.41|P-value:5.06E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.36|P-value:5.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.45|P-value:4.20E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.01|P-value:5.34E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.03|P-value:4.85E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.37|P-value:5.70E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.79|P-value:1.24E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.84|P-value:1.03E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-4.38|P-value:1.21E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.95|P-value:9.02E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.41|P-value:1.01E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.25|P-value:8.35E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.41|P-value:4.96E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.23|P-value:8.87E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.63|P-value:3.85E-6 ID:SGTC_2304|Compound:7443016|FD-Score:3.48|P-value:3.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.49|P-value:3.80E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.60|P-value:4.55E-6 ID:SGTC_2424|Compound:5537928|FD-Score:4.18|P-value:2.63E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.49|P-value:3.74E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.26|P-value:8.09E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.34|P-value:1.36E-5 ID:SGTC_3199|Compound:9111318|FD-Score:5.14|P-value:3.35E-7

Top fitness defect scores for YKR096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 5.90 1.1 µM 6.10E-9 mitochondrial stress 147 1.86E-9
2 SGTC_3199 9111318 5.14 49.5 µM 3.35E-7 8 1.35E-7
3 SGTC_2267 7931562 4.63 200.0 µM 3.85E-6 8 1.84E-6
4 SGTC_86 0417-1630 4.54 471.9 µM 5.82E-6 ubiquinone biosynthesis & proteasome 124 2.86E-6
5 SGTC_1155 4088-0394 4.41 48.2 µM 1.01E-5 18 5.18E-6
6 SGTC_3191 9110352 4.34 49.5 µM 1.36E-5 4 7.06E-6
7 SGTC_165 k038-0023 4.33 64.4 µM 1.42E-5 ubiquinone biosynthesis & proteasome 61 7.42E-6
8 SGTC_64 000l-0018 4.31 272.1 µM 1.54E-5 ubiquinone biosynthesis & proteasome 134 8.09E-6
9 SGTC_2424 5537928 4.18 59.2 µM 2.63E-5 31 1.43E-5
10 SGTC_717 1532-0246 4.03 73.2 µM 4.85E-5 Golgi 33 2.76E-5
11 SGTC_664 1222-0054 4.01 14.9 µM 5.34E-5 sphingolipid biosynthesis & PDR1 35 3.05E-5
12 SGTC_528 3492-0019 3.85 172.0 µM 1.00E-4 calcium & mitochondrial duress 230 6.00E-5
13 SGTC_903 1134-0042 3.84 114.0 µM 1.03E-4 21 6.16E-5
14 SGTC_784 4579-0127 3.79 173.0 µM 1.24E-4 24 7.52E-5
15 SGTC_2584 androsterone 3.55 48.7 µM 2.95E-4 cell wall 154 1.89E-4
16 SGTC_2942 9052777 3.49 62.2 µM 3.74E-4 55 2.44E-4
17 SGTC_2304 7443016 3.48 91.4 µM 3.84E-4 31 2.51E-4
18 SGTC_555 4296-0685 3.45 37.0 µM 4.20E-4 ergosterol biosynthesis 20 2.76E-4
19 SGTC_1884 5633444 3.41 25.0 µM 4.96E-4 redox potentiating 80 3.30E-4
20 SGTC_256 clotrimazole 3.40 625.0 nM 5.13E-4 ergosterol depletion effects on membrane 46 3.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 2.78E-33 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.188 3.65E-28 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.188 7.47E-28 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.183 8.80E-27 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.181 4.90E-26 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.175 1.48E-24 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.167 2.32E-22 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.162 3.68E-21 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.159 2.29E-20 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.157 6.56E-20 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.155 1.95E-19 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.154 2.67E-19 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.152 8.24E-19 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.147 1.41E-17 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.146 1.56E-17 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses