YKR102W / FLO10

Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR102W / FLO10

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-2.91|P-value:6.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.02|P-value:3.94E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.37|P-value:8.87E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.23|P-value:1.81E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.22|P-value:1.66E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.86|P-value:9.98E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.82|P-value:8.33E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.14|P-value:2.57E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.79|P-value:9.61E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.51|P-value:4.60E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:4.05E-9 ID:SGTC_1975|Compound:st070967|FD-Score:3.14|P-value:2.60E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.31|P-value:8.35E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.39|P-value:5.36E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.08|P-value:3.03E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.92|P-value:5.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:5.14|P-value:6.50E-9 ID:SGTC_2395|Compound:5646831|FD-Score:6.22|P-value:2.74E-12 ID:SGTC_2400|Compound:5203494|FD-Score:-4.18|P-value:1.66E-6 ID:SGTC_2404|Compound:5161160|FD-Score:6.75|P-value:3.89E-14 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.05|P-value:3.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.04|P-value:3.90E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-2.94|P-value:5.24E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.01|P-value:4.30E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.63|P-value:2.66E-5 ID:SGTC_2830|Compound:7992007|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.31|P-value:1.25E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.89|P-value:6.37E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-2.91|P-value:6.00E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.21|P-value:1.94E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.18|P-value:1.90E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-2.79|P-value:9.34E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.88|P-value:6.63E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-2.91|P-value:6.01E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.02|P-value:3.94E-6 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.37|P-value:8.87E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.23|P-value:1.81E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.22|P-value:1.66E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.86|P-value:9.98E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.82|P-value:8.33E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.14|P-value:2.57E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.79|P-value:9.61E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.51|P-value:4.60E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.19|P-value:4.05E-9 ID:SGTC_1975|Compound:st070967|FD-Score:3.14|P-value:2.60E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.31|P-value:8.35E-7 ID:SGTC_2241|Compound:6772625|FD-Score:-4.39|P-value:5.36E-7 ID:SGTC_2315|Compound:7733312|FD-Score:-3.08|P-value:3.03E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.92|P-value:5.78E-4 ID:SGTC_2394|Compound:5221648|FD-Score:5.14|P-value:6.50E-9 ID:SGTC_2395|Compound:5646831|FD-Score:6.22|P-value:2.74E-12 ID:SGTC_2400|Compound:5203494|FD-Score:-4.18|P-value:1.66E-6 ID:SGTC_2404|Compound:5161160|FD-Score:6.75|P-value:3.89E-14 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.05|P-value:3.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.04|P-value:3.90E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-2.94|P-value:5.24E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.01|P-value:4.30E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.63|P-value:2.66E-5 ID:SGTC_2830|Compound:7992007|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.31|P-value:1.25E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.89|P-value:6.37E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-2.91|P-value:6.00E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.21|P-value:1.94E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.18|P-value:1.90E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-2.79|P-value:9.34E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.88|P-value:6.63E-4

Top fitness defect scores for YKR102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2404 5161160 6.75 200.0 µM 3.89E-14 2 7.47E-12
2 SGTC_2395 5646831 6.22 180.2 µM 2.74E-12 5 2.42E-10
3 SGTC_2394 5221648 5.14 200.0 µM 6.50E-9 8 1.40E-7
4 SGTC_2962 9082311 4.18 13.2 µM 1.90E-6 15 1.48E-5
5 SGTC_359 0081-0058 3.86 15.9 µM 9.98E-6 60S ribosome export 46 5.77E-5
6 SGTC_2833 9001315 3.31 45.5 µM 1.25E-4 amide catabolism 84 4.64E-4
7 SGTC_760 0568-0725 3.30 82.9 µM 1.32E-4 24 4.84E-4
8 SGTC_261 5-fluorouridine 3.23 15.4 µM 1.81E-4 exosome 43 6.28E-4
9 SGTC_2957 9076800 3.21 11.5 µM 1.94E-4 44 6.66E-4
10 SGTC_1266 0828-0227 3.14 32.9 µM 2.57E-4 50 8.40E-4
11 SGTC_1975 st070967 3.14 30.8 µM 2.60E-4 72 8.49E-4
12 SGTC_2830 7992007 3.10 71.4 µM 3.09E-4 51 9.78E-4
13 SGTC_2546 rhodinyl acetate 3.09 100.0 µM 3.13E-4 41 9.87E-4
14 SGTC_2942 9052777 3.08 62.2 µM 3.36E-4 73 0.00105
15 SGTC_2516 gossypol 3.04 71.5 µM 3.90E-4 54 0.00119
16 SGTC_2607 solasodine 3.01 47.4 µM 4.30E-4 100 0.00129
17 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.77 70.1 µM 0.00111 119 0.00283
18 SGTC_310 1273-0058 2.74 1.1 µM 0.00125 mitochondrial stress 391 0.00311
19 SGTC_1701 st028638 2.71 40.4 µM 0.00135 75 0.00331
20 SGTC_757 1066-0008 2.71 322.0 µM 0.00139 Golgi 91 0.00339

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.356 1.30E-100 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.292 4.34E-67 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.284 3.21E-63 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.270 7.70E-57 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.264 1.46E-54 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.263 5.48E-54 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.260 5.94E-53 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.253 6.15E-50 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.244 1.34E-46 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.243 4.82E-46 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.243 2.96E-46 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.229 4.49E-41 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.229 5.23E-41 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.225 1.01E-39 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.225 1.51E-39 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis