YKR105C_p / VBA5

Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR105C / VBA5

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.47|P-value:2.72E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.25|P-value:6.15E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.26|P-value:7.73E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.45|P-value:2.91E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.66|P-value:1.32E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.43|P-value:4.31E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.33|P-value:4.55E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.14|P-value:1.60E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.49|P-value:2.59E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.27|P-value:5.58E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.01|P-value:3.28E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.39|P-value:3.64E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.12|P-value:1.73E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:6.67|P-value:1.17E-11 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.39|P-value:3.70E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.17|P-value:7.93E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.10|P-value:9.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.87|P-value:5.22E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.41|P-value:3.48E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.59|P-value:1.54E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.76|P-value:7.85E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.36|P-value:3.66E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.57|P-value:2.29E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-4.89|P-value:5.34E-7 ID:SGTC_1636|Compound:st007707|FD-Score:4.24|P-value:1.04E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.25|P-value:5.37E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.24|P-value:6.32E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.90|P-value:4.50E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-5.47|P-value:2.41E-8 ID:SGTC_2060|Compound:5238662|FD-Score:-4.87|P-value:6.13E-7 ID:SGTC_2065|Compound:5221596|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-4.38|P-value:6.38E-6 ID:SGTC_2481|Compound:5478948|FD-Score:4.03|P-value:2.61E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.73|P-value:8.95E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.57|P-value:2.61E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.61|P-value:1.64E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.14|P-value:8.95E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.98|P-value:3.62E-5 ID:SGTC_3093|Compound:9117344|FD-Score:6.08|P-value:5.55E-10 ID:SGTC_48|Compound:0382-0018|FD-Score:3.18|P-value:7.10E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.47|P-value:2.72E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.25|P-value:6.15E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-5.26|P-value:7.73E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.45|P-value:2.91E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.66|P-value:1.32E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.43|P-value:4.31E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.33|P-value:4.55E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.14|P-value:1.60E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:-3.49|P-value:2.59E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.27|P-value:5.58E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.01|P-value:3.28E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.41|P-value:3.07E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.39|P-value:3.64E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.12|P-value:1.73E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:6.67|P-value:1.17E-11 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.39|P-value:3.70E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.17|P-value:7.93E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.10|P-value:9.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.87|P-value:5.22E-7 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.41|P-value:3.48E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.59|P-value:1.54E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.76|P-value:7.85E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.36|P-value:3.66E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.57|P-value:2.29E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-4.89|P-value:5.34E-7 ID:SGTC_1636|Compound:st007707|FD-Score:4.24|P-value:1.04E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.25|P-value:5.37E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.14|P-value:8.94E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.24|P-value:6.32E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.90|P-value:4.50E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-5.47|P-value:2.41E-8 ID:SGTC_2060|Compound:5238662|FD-Score:-4.87|P-value:6.13E-7 ID:SGTC_2065|Compound:5221596|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.47|P-value:2.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-4.38|P-value:6.38E-6 ID:SGTC_2481|Compound:5478948|FD-Score:4.03|P-value:2.61E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.73|P-value:8.95E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.57|P-value:2.61E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.61|P-value:1.64E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.14|P-value:8.95E-4 ID:SGTC_3009|Compound:9080819|FD-Score:-3.98|P-value:3.62E-5 ID:SGTC_3093|Compound:9117344|FD-Score:6.08|P-value:5.55E-10

Top fitness defect scores for YKR105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1101 ebselen 6.67 5.3 µM 1.17E-11 3 1.30E-11
2 SGTC_3093 9117344 6.08 49.5 µM 5.55E-10 60S ribosome export 1 6.12E-10
3 SGTC_1267 0828-0272 4.87 9.5 µM 5.22E-7 9 5.64E-7
4 SGTC_1625 st003711 4.57 30.1 µM 2.29E-6 calcium & mitochondrial duress 23 2.46E-6
5 SGTC_631 k072-0230 4.43 41.5 µM 4.31E-6 60S ribosome export 6 4.64E-6
6 SGTC_1636 st007707 4.24 68.9 µM 1.04E-5 44 1.12E-5
7 SGTC_639 0833-0042 4.14 114.0 µM 1.60E-5 40 1.71E-5
8 SGTC_954 1189-0853 4.14 2.9 µM 1.62E-5 endomembrane recycling 36 1.73E-5
9 SGTC_951 1171-0579 4.12 82.7 µM 1.73E-5 cell wall 70 1.86E-5
10 SGTC_2481 5478948 4.03 45.2 µM 2.61E-5 PDR1 33 2.79E-5
11 SGTC_2052 5265182 3.90 7.1 µM 4.50E-5 34 4.80E-5
12 SGTC_1388 3346-4487 3.76 254.0 µM 7.85E-5 33 8.35E-5
13 SGTC_2532 xanthone 3.73 78.9 µM 8.95E-5 36 9.52E-5
14 SGTC_1580 hydrocortisone 21-hemisuccinate 3.69 43.2 µM 1.04E-4 20 1.11E-4
15 SGTC_2832 7992762 3.68 52.0 µM 1.08E-4 39 1.15E-4
16 SGTC_1451 4152-0210 3.63 104.0 µM 1.31E-4 37 1.40E-4
17 SGTC_1097 itavastatin 3.60 7.2 µM 1.52E-4 azole & statin 29 1.61E-4
18 SGTC_1285 0929-0069 3.59 65.5 µM 1.54E-4 28 1.63E-4
19 SGTC_1833 st055984 3.58 71.0 µM 1.62E-4 26 1.72E-4
20 SGTC_1854 st056233 3.52 32.9 µM 2.01E-4 amide catabolism 29 2.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.75E-7 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.079 4.88E-6 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.075 1.29E-5 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.075 1.49E-5 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.073 2.23E-5 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.073 2.56E-5 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.072 2.80E-5 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p
0.070 5.20E-5 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.065 1.47E-4 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.065 1.48E-4 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.065 1.56E-4 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.064 2.06E-4 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.064 2.10E-4 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.064 2.67E-4 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.063 2.53E-4 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background