YLL007C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL007C / YLL007C

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:4.63|P-value:8.07E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.16|P-value:3.43E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.80|P-value:9.43E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.99|P-value:5.51E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.02|P-value:5.17E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.79|P-value:9.72E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.33|P-value:1.40E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.19|P-value:3.09E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.64|P-value:7.86E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.92|P-value:6.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.11|P-value:3.97E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.39|P-value:1.69E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.96|P-value:6.11E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-5.47|P-value:8.07E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.24|P-value:4.39E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.22|P-value:2.86E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.58|P-value:2.89E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.08|P-value:4.83E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.35|P-value:1.95E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.91|P-value:1.07E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.30|P-value:2.25E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.48|P-value:4.28E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.95|P-value:6.21E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.60|P-value:8.88E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.30|P-value:2.23E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.83|P-value:8.68E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.59|P-value:1.55E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.95|P-value:6.16E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.88|P-value:7.48E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:5.41E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.60|P-value:1.49E-4 ID:SGTC_2109|Compound:5483026|FD-Score:5.57|P-value:3.06E-6 ID:SGTC_2120|Compound:5538279|FD-Score:4.32|P-value:2.09E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.90|P-value:7.06E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.27|P-value:2.49E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.99|P-value:2.45E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.27|P-value:2.43E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.56|P-value:1.01E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.31|P-value:3.49E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:-4.02|P-value:7.95E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.15|P-value:1.41E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.95|P-value:2.79E-5 ID:SGTC_2855|Compound:9016525|FD-Score:5.88|P-value:9.12E-7 ID:SGTC_2942|Compound:9052777|FD-Score:4.61|P-value:8.62E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.63|P-value:1.33E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.19|P-value:1.23E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:4.63|P-value:8.07E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.16|P-value:3.43E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.80|P-value:9.43E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.99|P-value:5.51E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.02|P-value:5.17E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.79|P-value:9.72E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.33|P-value:1.40E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:4.19|P-value:3.09E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.64|P-value:7.86E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:3.92|P-value:6.70E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.11|P-value:3.97E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.39|P-value:1.69E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.96|P-value:6.11E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-5.47|P-value:8.07E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:-4.24|P-value:4.39E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.22|P-value:2.86E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.58|P-value:2.89E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.08|P-value:4.83E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.35|P-value:1.95E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.91|P-value:1.07E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.30|P-value:2.25E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:5.48|P-value:4.28E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.95|P-value:6.21E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.60|P-value:8.88E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.30|P-value:2.23E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.83|P-value:8.68E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.59|P-value:1.55E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.95|P-value:6.16E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.88|P-value:7.48E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.16|P-value:5.41E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.60|P-value:1.49E-4 ID:SGTC_2109|Compound:5483026|FD-Score:5.57|P-value:3.06E-6 ID:SGTC_2120|Compound:5538279|FD-Score:4.32|P-value:2.09E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.90|P-value:7.06E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.27|P-value:2.49E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.99|P-value:2.45E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.27|P-value:2.43E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.56|P-value:1.01E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.31|P-value:3.49E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:-4.02|P-value:7.95E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.15|P-value:1.41E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.95|P-value:2.79E-5 ID:SGTC_2855|Compound:9016525|FD-Score:5.88|P-value:9.12E-7 ID:SGTC_2942|Compound:9052777|FD-Score:4.61|P-value:8.62E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-4.63|P-value:1.33E-4 ID:SGTC_3140|Compound:9094243|FD-Score:5.19|P-value:1.23E-5

Top fitness defect scores for YLL007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1036 k216-0215 7.08 33.5 µM 4.83E-9 mitochondrial response to ROS 9 7.15E-13
2 SGTC_1161 k007-0610 6.91 110.0 µM 1.07E-8 ERAD & cell cycle 40 2.41E-12
3 SGTC_568 1193-0097 6.33 7.5 µM 1.40E-7 ERAD & cell cycle 56 1.21E-10
4 SGTC_2855 9016525 5.88 58.4 µM 9.12E-7 3 2.09E-9
5 SGTC_1026 k007-1105 5.58 30.6 µM 2.89E-6 ERAD & cell cycle 50 1.20E-8
6 SGTC_2109 5483026 5.57 200.0 µM 3.06E-6 RSC complex & mRNA processing 4 1.31E-8
7 SGTC_1223 0764-0573 5.48 147.0 µM 4.28E-6 2 2.18E-8
8 SGTC_3140 9094243 5.19 49.5 µM 1.23E-5 10 1.07E-7
9 SGTC_2776 terbinafine 5.15 19.9 µM 1.41E-5 cell wall signaling 31 1.33E-7
10 SGTC_2571 chrysanthemic acid 4.99 100.0 µM 2.45E-5 6 3.05E-7
11 SGTC_2849 9019321 4.95 13.0 µM 2.79E-5 17 3.70E-7
12 SGTC_733 4069-0007 4.64 56.1 µM 7.86E-5 ERAD & cell cycle 62 1.76E-6
13 SGTC_60 0986-0278 4.63 202.0 µM 8.07E-5 5 1.83E-6
14 SGTC_2942 9052777 4.61 62.2 µM 8.62E-5 17 2.02E-6
15 SGTC_1344 1488-0097 4.60 29.1 µM 8.88E-5 10 2.12E-6
16 SGTC_2636 apigenin dimethyl ether 4.56 100.0 µM 1.01E-4 27 2.59E-6
17 SGTC_825 1988-2224 4.39 89.6 µM 1.69E-4 cell wall signaling 25 5.58E-6
18 SGTC_1042 0350-0096 4.35 82.0 µM 1.95E-4 TSC3-RPN4 17 6.89E-6
19 SGTC_2120 5538279 4.32 152.0 µM 2.09E-4 12 7.67E-6
20 SGTC_1394 3474-0001 4.30 65.7 µM 2.23E-4 endomembrane recycling 33 8.43E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 1.78E-38 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.221 2.58E-38 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.214 3.77E-36 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.206 1.23E-33 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.155 1.59E-19 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.153 4.28E-19 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.150 2.35E-18 YBR036C CSG2 hom Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
0.150 2.36E-18 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.135 5.28E-15 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.133 8.70E-15 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.132 2.13E-14 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.125 3.33E-13 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.124 6.54E-13 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.123 7.96E-13 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 2.45E-12 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate