YLL011W / SOF1

Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL011W / SOF1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.85|P-value:7.75E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.03|P-value:2.96E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.45|P-value:4.72E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.92|P-value:4.54E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:3.81|P-value:7.94E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.35|P-value:4.36E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.80|P-value:4.52E-40 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.01|P-value:3.19E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.35|P-value:4.45E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:3.63|P-value:2.01E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.34|P-value:7.54E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.91|P-value:4.88E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.37|P-value:6.67E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.95|P-value:5.30E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:-2.80|P-value:9.42E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.94|P-value:4.27E-4 ID:SGTC_1715|Compound:st032160|FD-Score:5.45|P-value:3.91E-10 ID:SGTC_1716|Compound:st033144|FD-Score:-4.82|P-value:3.85E-8 ID:SGTC_1719|Compound:st032227|FD-Score:-3.53|P-value:4.23E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.61|P-value:2.93E-5 ID:SGTC_1795|Compound:st049545|FD-Score:-3.24|P-value:1.54E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.88|P-value:5.52E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.85|P-value:6.55E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.09|P-value:2.27E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.35|P-value:7.31E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-2.82|P-value:8.68E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.16|P-value:1.73E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.24|P-value:1.21E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-8.80|P-value:3.47E-23 ID:SGTC_2787|Compound:5284540|FD-Score:3.69|P-value:1.49E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-4.03|P-value:3.62E-6 ID:SGTC_2791|Compound:5663188|FD-Score:2.92|P-value:4.53E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.28|P-value:9.20E-7 ID:SGTC_2881|Compound:9058953|FD-Score:-4.36|P-value:5.97E-7 ID:SGTC_2951|Compound:9072950|FD-Score:-3.22|P-value:1.68E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-2.84|P-value:8.05E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.37|P-value:8.91E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.36|P-value:7.10E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:2.92|P-value:4.70E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.85|P-value:7.75E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.03|P-value:2.96E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.45|P-value:4.72E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.92|P-value:4.54E-6 ID:SGTC_331|Compound:k048-0133|FD-Score:3.81|P-value:7.94E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.35|P-value:4.36E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.80|P-value:4.52E-40 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.01|P-value:3.19E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.35|P-value:4.45E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:3.63|P-value:2.01E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.34|P-value:7.54E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.91|P-value:4.88E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.37|P-value:6.67E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.95|P-value:5.30E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:-2.80|P-value:9.42E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.94|P-value:4.27E-4 ID:SGTC_1715|Compound:st032160|FD-Score:5.45|P-value:3.91E-10 ID:SGTC_1716|Compound:st033144|FD-Score:-4.82|P-value:3.85E-8 ID:SGTC_1719|Compound:st032227|FD-Score:-3.53|P-value:4.23E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.61|P-value:2.93E-5 ID:SGTC_1795|Compound:st049545|FD-Score:-3.24|P-value:1.54E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.88|P-value:5.52E-6 ID:SGTC_1799|Compound:st045822|FD-Score:3.85|P-value:6.55E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.09|P-value:2.27E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.26|P-value:1.11E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.35|P-value:7.31E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-2.82|P-value:8.68E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.16|P-value:1.73E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.24|P-value:1.21E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-8.80|P-value:3.47E-23 ID:SGTC_2787|Compound:5284540|FD-Score:3.69|P-value:1.49E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-4.03|P-value:3.62E-6 ID:SGTC_2791|Compound:5663188|FD-Score:2.92|P-value:4.53E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.28|P-value:9.20E-7 ID:SGTC_2881|Compound:9058953|FD-Score:-4.36|P-value:5.97E-7 ID:SGTC_2951|Compound:9072950|FD-Score:-3.22|P-value:1.68E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-2.84|P-value:8.05E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.37|P-value:8.91E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.36|P-value:7.10E-5

Top fitness defect scores for YLL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1715 st032160 5.45 10.2 µM 3.91E-10 1 2.58E-8 0.91
2 SGTC_368 fentichlor 4.35 4.6 µM 4.36E-7 6 6.81E-6 0.39
3 SGTC_419 nsc-638432 4.35 893.0 µM 4.45E-7 DNA damage response 2 6.92E-6 0.19
4 SGTC_311 1315-0136 3.92 58.0 µM 4.54E-6 4 4.40E-5 0.07
5 SGTC_705 1124-0212 3.91 310.0 µM 4.88E-6 7 4.65E-5 0.03
6 SGTC_1798 st045719 3.88 61.0 µM 5.52E-6 5 5.14E-5 0.08
7 SGTC_1799 st045822 3.85 46.1 µM 6.55E-6 3 5.88E-5 0.01
8 SGTC_331 k048-0133 3.81 24.5 µM 7.94E-6 RSC & ERG11 14 6.86E-5 0.00
9 SGTC_2787 5284540 3.69 71.4 µM 1.49E-5 10 1.13E-4 0.05
10 SGTC_571 k831-0106 3.63 44.2 µM 2.01E-5 7 1.44E-4 0.02
11 SGTC_128 0906-2981 3.45 13.4 µM 4.72E-5 14 2.84E-4 0.03
12 SGTC_922 1866-0035 3.37 480.0 µM 6.67E-5 excess fatty acid 16 3.74E-4 0.11
13 SGTC_3203 9113543 3.36 49.5 µM 7.10E-5 14 3.93E-4 0.06
14 SGTC_2273 7815444 3.35 169.1 µM 7.31E-5 6 4.02E-4 0.03
15 SGTC_645 0845-0943 3.34 5.4 µM 7.54E-5 60S ribosome export 7 4.12E-4 0.00
16 SGTC_306 1672-3436 3.28 11.6 µM 1.00E-4 Golgi 7 5.18E-4 0.05
17 SGTC_1923 st058458 3.26 19.1 µM 1.11E-4 17 5.62E-4 0.02
18 SGTC_2580 diallyl disulphide 3.24 81.4 µM 1.21E-4 15 6.01E-4 0.04
19 SGTC_2452 5863136 3.16 48.4 µM 1.73E-4 8 7.99E-4 0.07
20 SGTC_1874 staurosporine 3.09 7.6 µM 2.27E-4 cell wall signaling 9 9.94E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 2.96E-33 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.187 6.93E-28 YMR304C-A_d YMR304C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
0.173 5.18E-24 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.169 8.18E-23 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.167 2.64E-22 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.162 3.12E-21 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.157 7.02E-20 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.150 2.72E-18 YOL026C MIM1 het Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
0.147 1.50E-17 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.146 2.30E-17 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.141 2.01E-16 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.134 6.63E-15 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.128 9.37E-14 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.121 2.19E-12 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.116 1.70E-11 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex