HIPHOP chemogenomics database

YLL012W / YEH1

Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes

Zygosity: Homozygous strain

fixedexpanded
Profile for YLL012W / YEH1

Click on Significant Values for Screen Details

Top fitness defect scores for YLL012W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1083	didemethylchlorpromazine sulfoxide	4.85	707.4 nM	5.10E-8	redox potentiating	48	6.29E-7
2	SGTC_822	1487-0950	3.81	154.0 µM	1.41E-5		18	7.05E-5
3	SGTC_2379	9035213	3.78	200.0 µM	1.60E-5		26	7.84E-5
4	SGTC_996	3970-0799	3.48	1.8 µM	6.40E-5		116	2.52E-4
5	SGTC_2602	kawain	3.32	100.0 µM	1.29E-4		51	4.55E-4
6	SGTC_986	1493-0483	3.23	84.0 µM	1.88E-4		36	6.24E-4
7	SGTC_1988	st071872	3.23	53.4 µM	1.90E-4		30	6.29E-4
8	SGTC_824	1304-0008	3.13	100.0 µM	2.78E-4	DNA damage response	75	8.68E-4
9	SGTC_2002	4023503	3.09	131.0 µM	3.30E-4	mitochondrial processes	77	0.00100
10	SGTC_3315	9136395	3.07	68.5 µM	3.64E-4		37	0.00109
11	SGTC_1996	st072960	3.06	66.8 µM	3.67E-4		50	0.00110
12	SGTC_2435	5706476	2.96	10.6 µM	5.48E-4		71	0.00154
13	SGTC_1312	1218-2183	2.88	165.0 µM	7.57E-4		42	0.00202
14	SGTC_1059	3448-6867	2.86	171.0 µM	7.96E-4		58	0.00210
15	SGTC_1725	st036284	2.83	20.6 µM	9.09E-4		91	0.00235
16	SGTC_1061	3448-9325	2.82	110.0 µM	9.15E-4		70	0.00237
17	SGTC_2375	9072683	2.80	200.0 µM	0.00100	mitochondrial processes	84	0.00255
18	SGTC_426	0988-0037	2.80	14.6 µM	0.00101	ERAD & cell cycle	102	0.00257
19	SGTC_1032	k061-1018	2.67	98.7 µM	0.00158		113	0.00375
20	SGTC_3313	9133968	2.64	57.0 µM	0.00180		62	0.00418

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.354	1.76E-99	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.302	1.01E-71	YPL251W_d	YPL251W_d	het	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.253	4.13E-50	YPL252C	YAH1	het	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.248	2.21E-48	YGR193C	PDX1	hom	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.241	1.60E-45	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.234	8.45E-43	YDR431W_d	YDR431W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.223	6.21E-39	YML118W	NGL3	hom	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.222	9.42E-39	YFL063W_d	YFL063W_d	hom	Dubious open reading frame, based on available experimental and comparative sequence data
0.220	4.10E-38	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.218	2.59E-37	YOL141W	PPM2	hom	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.213	7.54E-36	YBL066C	SEF1	hom	Putative transcription factor, has homolog in Kluyveromyces lactis
0.208	4.66E-34	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.208	4.21E-34	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.207	7.13E-34	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204	5.31E-33	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)