YLL015W / BPT1

ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL015W / BPT1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.53|P-value:2.88E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.02|P-value:4.19E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.21|P-value:8.82E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.98|P-value:9.70E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.76|P-value:1.19E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.67|P-value:7.52E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.21|P-value:8.93E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.97|P-value:5.05E-5 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.23|P-value:8.31E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.26|P-value:3.64E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.99|P-value:9.48E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.16|P-value:2.28E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.46|P-value:1.69E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.29|P-value:6.72E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:5.59E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.02|P-value:8.66E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.03|P-value:8.20E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.05|P-value:7.70E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.42|P-value:1.99E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.68|P-value:1.61E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.25|P-value:6.19E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.47|P-value:3.50E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.41|P-value:4.44E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.36|P-value:5.20E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.97|P-value:9.99E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.53|P-value:2.88E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.02|P-value:4.19E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.21|P-value:8.82E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.98|P-value:9.70E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.76|P-value:1.19E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.67|P-value:7.52E-5 ID:SGTC_447|Compound:ml7|FD-Score:-3.21|P-value:8.93E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:-3.97|P-value:5.05E-5 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.23|P-value:8.31E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.26|P-value:3.64E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.17|P-value:5.06E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:2.99|P-value:9.48E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.16|P-value:2.28E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.54|P-value:1.24E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.46|P-value:1.69E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.29|P-value:6.72E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.34|P-value:5.59E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.02|P-value:8.66E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.03|P-value:8.20E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.05|P-value:7.70E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.42|P-value:1.99E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.47|P-value:1.64E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.68|P-value:1.61E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.25|P-value:6.19E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.47|P-value:3.50E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.41|P-value:4.44E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.36|P-value:5.20E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.97|P-value:9.99E-4

Top fitness defect scores for YLL015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2797 7859098 4.25 81.8 µM 6.19E-6 24 1.08E-5
2 SGTC_310 1273-0058 3.67 1.1 µM 7.52E-5 mitochondrial stress 265 1.21E-4
3 SGTC_1085 doxorubicin 3.54 7.7 µM 1.24E-4 anthracycline transcription coupled DNA repair 29 1.96E-4
4 SGTC_2089 5281248 3.47 129.7 µM 1.64E-4 superoxide 39 2.57E-4
5 SGTC_1216 1165-0504 3.46 9.7 µM 1.69E-4 24 2.66E-4
6 SGTC_1834 st055981 3.44 52.8 µM 1.86E-4 RPP1 & pyrimidine depletion 49 2.92E-4
7 SGTC_1972 st070201 3.42 17.4 µM 1.99E-4 40 3.11E-4
8 SGTC_1584 6-fluoro-dl-tryptophan 3.40 90.0 µM 2.14E-4 mitochondrial processes 32 3.33E-4
9 SGTC_2989 9073649 3.38 71.4 µM 2.32E-4 65 3.60E-4
10 SGTC_1086 cerivastatin 3.36 2.2 µM 2.53E-4 azole & statin 24 3.92E-4
11 SGTC_634 1611-4317 3.26 11.2 µM 3.64E-4 ERG2 37 5.56E-4
12 SGTC_1088 bifonazole 3.23 369.0 nM 4.14E-4 35 6.30E-4
13 SGTC_1398 3558-0053 3.20 112.0 µM 4.53E-4 12 6.87E-4
14 SGTC_734 2023-0417 3.17 80.0 µM 5.06E-4 ergosterol biosynthesis 46 7.65E-4
15 SGTC_1946 st076057 3.05 65.1 µM 7.70E-4 22 0.00115
16 SGTC_1891 st059073 3.03 26.2 µM 8.20E-4 TSC3-RPN4 61 0.00122
17 SGTC_1079 idarubicin 3.02 2.4 µM 8.49E-4 DNA damage response 48 0.00126
18 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.02 62.6 µM 8.66E-4 TSC3-RPN4 41 0.00128
19 SGTC_763 3453-1109 2.99 128.0 µM 9.48E-4 54 0.00140
20 SGTC_180 1486-1293 2.98 102.8 µM 9.70E-4 87 0.00143

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.20E-17 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.132 1.55E-14 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.130 5.21E-14 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.120 3.31E-12 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.116 1.57E-11 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.114 3.98E-11 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.108 3.38E-10 YML090W_d YML090W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
0.105 1.25E-9 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.105 1.30E-9 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.104 1.43E-9 YPR195C_d YPR195C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.104 1.74E-9 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.100 5.72E-9 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.100 5.69E-9 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.100 7.08E-9 YMR120C ADE17 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.097 1.72E-8 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene