YLL020C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL020C / YLL020C

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-3.00|P-value:9.05E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.07|P-value:5.43E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.74|P-value:3.60E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.79|P-value:2.82E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:2.98|P-value:7.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.12|P-value:2.81E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:3.17|P-value:3.77E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.76|P-value:4.39E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.56|P-value:1.96E-9 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.04|P-value:7.78E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.09|P-value:4.98E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-2.98|P-value:9.60E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.36|P-value:2.30E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.56|P-value:6.72E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.90|P-value:2.39E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.68|P-value:4.52E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.24|P-value:3.63E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:2.95|P-value:8.47E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.64|P-value:4.28E-7 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.19|P-value:3.40E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.79|P-value:3.87E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.19|P-value:4.28E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.06|P-value:7.12E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.05|P-value:7.52E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.03|P-value:8.52E-11 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.12|P-value:5.87E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.76|P-value:2.19E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.10|P-value:6.11E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.72|P-value:3.78E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.04|P-value:5.99E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.70|P-value:4.15E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-3.53|P-value:1.16E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.92|P-value:9.41E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.34|P-value:2.53E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.38|P-value:1.62E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.22|P-value:3.03E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.05|P-value:8.49E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.25|P-value:3.57E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.63|P-value:5.65E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.03|P-value:1.28E-5 ID:SGTC_2254|Compound:7938975|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.96|P-value:1.81E-5 ID:SGTC_2374|Compound:9071832|FD-Score:5.39|P-value:5.70E-9 ID:SGTC_2376|Compound:9072922|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.11|P-value:6.46E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.99|P-value:1.56E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.10|P-value:6.62E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.78|P-value:1.95E-7 ID:SGTC_2794|Compound:7785382|FD-Score:4.14|P-value:5.40E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.39|P-value:1.54E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.90|P-value:2.32E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_2894|Compound:9048625|FD-Score:2.99|P-value:7.15E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.71|P-value:4.10E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.00|P-value:8.98E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.00|P-value:8.88E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.85|P-value:2.18E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.00|P-value:9.05E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.07|P-value:5.43E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.74|P-value:3.60E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.79|P-value:2.82E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:2.98|P-value:7.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.12|P-value:2.81E-8 ID:SGTC_315|Compound:k915-0449|FD-Score:3.17|P-value:3.77E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.76|P-value:4.39E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.56|P-value:1.96E-9 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.04|P-value:7.78E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.09|P-value:4.98E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-2.98|P-value:9.60E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.36|P-value:2.30E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.56|P-value:6.72E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.90|P-value:2.39E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.68|P-value:4.52E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.24|P-value:3.63E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:2.95|P-value:8.47E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.64|P-value:4.28E-7 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.47|P-value:1.13E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.19|P-value:3.40E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.79|P-value:3.87E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.19|P-value:4.28E-6 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.06|P-value:7.12E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.05|P-value:7.52E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:6.03|P-value:8.52E-11 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.12|P-value:5.87E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:-3.15|P-value:5.13E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.76|P-value:2.19E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.10|P-value:6.11E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.72|P-value:3.78E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.04|P-value:5.99E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.70|P-value:4.15E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-3.53|P-value:1.16E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.92|P-value:9.41E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.34|P-value:2.53E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.38|P-value:1.62E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.22|P-value:3.03E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.05|P-value:8.49E-6 ID:SGTC_2060|Compound:5238662|FD-Score:3.06|P-value:5.59E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.25|P-value:3.57E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.63|P-value:5.65E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.03|P-value:1.28E-5 ID:SGTC_2254|Compound:7938975|FD-Score:3.08|P-value:5.22E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.50|P-value:1.01E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.38|P-value:1.64E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.96|P-value:1.81E-5 ID:SGTC_2374|Compound:9071832|FD-Score:5.39|P-value:5.70E-9 ID:SGTC_2376|Compound:9072922|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.11|P-value:6.46E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.99|P-value:1.56E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.06|P-value:5.56E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.10|P-value:6.62E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_2787|Compound:5284540|FD-Score:4.78|P-value:1.95E-7 ID:SGTC_2794|Compound:7785382|FD-Score:4.14|P-value:5.40E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.39|P-value:1.54E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.90|P-value:2.32E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_2894|Compound:9048625|FD-Score:2.99|P-value:7.15E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.71|P-value:4.10E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.00|P-value:8.98E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.00|P-value:8.88E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.85|P-value:2.18E-5

Top fitness defect scores for YLL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1384 3089-0840 6.03 101.0 µM 8.52E-11 4 8.19E-10
2 SGTC_453 enantio-paf c16 5.56 10.0 µM 1.96E-9 66 1.37E-8
3 SGTC_2374 9071832 5.39 200.0 µM 5.70E-9 endomembrane recycling 8 3.58E-8
4 SGTC_310 1273-0058 5.12 1.1 µM 2.81E-8 mitochondrial stress 179 1.51E-7
5 SGTC_2787 5284540 4.78 71.4 µM 1.95E-7 10 8.58E-7
6 SGTC_1504 k297-0033 4.76 30.0 µM 2.19E-7 5 9.53E-7
7 SGTC_1059 3448-6867 4.64 171.0 µM 4.28E-7 2 1.74E-6
8 SGTC_753 1322-0200 4.56 289.0 µM 6.72E-7 6 2.61E-6
9 SGTC_2296 7971656 4.38 126.5 µM 1.64E-6 35 5.82E-6
10 SGTC_1167 k781-0610 4.19 148.0 µM 4.28E-6 RNA processing & uracil transport 21 1.38E-5
11 SGTC_2794 7785382 4.14 27.3 µM 5.40E-6 29 1.70E-5
12 SGTC_2413 inermin 4.11 26.1 µM 6.46E-6 47 2.00E-5
13 SGTC_2724 maprotiline 4.10 69.6 µM 6.62E-6 ERG2 13 2.04E-5
14 SGTC_2042 p-Dimethylaminoacetophenone 4.05 200.0 µM 8.49E-6 14 2.55E-5
15 SGTC_3244 9134489 3.85 49.5 µM 2.18E-5 20 5.96E-5
16 SGTC_302 1094-0063 3.79 18.9 µM 2.82E-5 16 7.52E-5
17 SGTC_299 1273-0059 3.74 1.4 µM 3.60E-5 28 9.37E-5
18 SGTC_1634 st006576 3.72 41.0 µM 3.78E-5 TSC3-RPN4 25 9.78E-5
19 SGTC_3026 9090633 3.71 49.5 µM 4.10E-5 28 1.05E-4
20 SGTC_1705 st027868 3.70 56.3 µM 4.15E-5 12 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.81E-15 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.36E-12 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.121 2.16E-12 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.117 9.53E-12 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.60E-10 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.108 3.50E-10 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.108 3.58E-10 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.099 9.95E-9 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.093 7.16E-8 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.092 1.02E-7 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.090 1.57E-7 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.090 1.61E-7 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.089 2.31E-7 YGR007W ECT1 hom Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
0.088 2.86E-7 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.087 4.62E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect