YLL028W / TPO1

Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL028W / TPO1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.93|P-value:2.78E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.92|P-value:2.00E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:2.78|P-value:5.19E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.17|P-value:9.54E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.31|P-value:4.96E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.27|P-value:8.94E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.46|P-value:2.32E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.26|P-value:6.01E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:3.09E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.02|P-value:2.72E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.87|P-value:5.23E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.04|P-value:1.68E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:2.69|P-value:7.28E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.70|P-value:6.83E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-2.89|P-value:4.81E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.59|P-value:1.22E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.22|P-value:7.56E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.46|P-value:3.70E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.69|P-value:7.49E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.13|P-value:1.11E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.17|P-value:1.43E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.05|P-value:2.39E-4 ID:SGTC_1812|Compound:st052057|FD-Score:2.98|P-value:2.18E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.22|P-value:7.43E-5 ID:SGTC_1843|Compound:st055809|FD-Score:-2.84|P-value:5.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.07|P-value:1.46E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.86|P-value:3.64E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.93|P-value:2.79E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.93|P-value:1.97E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.14|P-value:1.65E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.00|P-value:1.34E-6 ID:SGTC_2168|Compound:5727979|FD-Score:-2.96|P-value:3.57E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.92|P-value:2.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.85|P-value:5.69E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-2.77|P-value:7.83E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.18|P-value:4.47E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.64|P-value:8.91E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.72|P-value:9.56E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-2.79|P-value:7.07E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.46|P-value:3.64E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.06|P-value:1.53E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.46|P-value:2.30E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.23|P-value:1.10E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.30|P-value:7.90E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-4.17|P-value:8.46E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-8.29|P-value:5.31E-22 ID:SGTC_2947|Compound:9072639|FD-Score:-5.63|P-value:4.31E-11 ID:SGTC_2949|Compound:9072542|FD-Score:4.52|P-value:5.71E-8 ID:SGTC_2952|Compound:9073731|FD-Score:-4.37|P-value:2.50E-7 ID:SGTC_3052|Compound:9092717|FD-Score:2.84|P-value:4.02E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.83|P-value:3.34E-6 ID:SGTC_3186|Compound:9110464|FD-Score:2.72|P-value:6.67E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.99|P-value:2.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.19|P-value:8.60E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.20|P-value:1.24E-4 ID:SGTC_3195|Compound:9113082|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.92|P-value:4.12E-4 ID:SGTC_3224|Compound:9130643|FD-Score:2.99|P-value:2.13E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.02|P-value:2.77E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:2.93|P-value:2.78E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.92|P-value:2.00E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:2.78|P-value:5.19E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.17|P-value:9.54E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.31|P-value:4.96E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.27|P-value:8.94E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.46|P-value:2.32E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.26|P-value:6.01E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:3.09E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.02|P-value:2.72E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.87|P-value:5.23E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.04|P-value:1.68E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:2.69|P-value:7.28E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.70|P-value:6.83E-6 ID:SGTC_858|Compound:0438-0351|FD-Score:-2.89|P-value:4.81E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.59|P-value:1.22E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.22|P-value:7.56E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.46|P-value:3.70E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.69|P-value:7.49E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.13|P-value:1.11E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.17|P-value:1.43E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.05|P-value:2.39E-4 ID:SGTC_1812|Compound:st052057|FD-Score:2.98|P-value:2.18E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.22|P-value:7.43E-5 ID:SGTC_1843|Compound:st055809|FD-Score:-2.84|P-value:5.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.07|P-value:1.46E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.86|P-value:3.64E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.93|P-value:2.79E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.93|P-value:1.97E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.14|P-value:1.65E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.00|P-value:1.34E-6 ID:SGTC_2168|Compound:5727979|FD-Score:-2.96|P-value:3.57E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.92|P-value:2.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-2.85|P-value:5.69E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-2.77|P-value:7.83E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.18|P-value:4.47E-7 ID:SGTC_2298|Compound:7976326|FD-Score:2.64|P-value:8.91E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.72|P-value:9.56E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-2.79|P-value:7.07E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.46|P-value:3.64E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.06|P-value:1.53E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.46|P-value:2.30E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.23|P-value:1.10E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.30|P-value:7.90E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-4.17|P-value:8.46E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-8.29|P-value:5.31E-22 ID:SGTC_2947|Compound:9072639|FD-Score:-5.63|P-value:4.31E-11 ID:SGTC_2949|Compound:9072542|FD-Score:4.52|P-value:5.71E-8 ID:SGTC_2952|Compound:9073731|FD-Score:-4.37|P-value:2.50E-7 ID:SGTC_3052|Compound:9092717|FD-Score:2.84|P-value:4.02E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.83|P-value:3.34E-6 ID:SGTC_3186|Compound:9110464|FD-Score:2.72|P-value:6.67E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.99|P-value:2.12E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.19|P-value:8.60E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.20|P-value:1.24E-4 ID:SGTC_3195|Compound:9113082|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-2.92|P-value:4.12E-4 ID:SGTC_3224|Compound:9130643|FD-Score:2.99|P-value:2.13E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.02|P-value:2.77E-4

Top fitness defect scores for YLL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2949 9072542 4.52 2.2 µM 5.71E-8 TSC3-RPN4 24 3.10E-6
2 SGTC_2295 7971645 4.18 200.0 µM 4.47E-7 16 1.43E-5
3 SGTC_2035 5154463 4.00 94.6 µM 1.34E-6 14 3.22E-5
4 SGTC_1861 st057647 3.93 17.4 µM 1.97E-6 21 4.31E-5
5 SGTC_353 1988-1175 3.92 58.3 µM 2.00E-6 unfolded protein response 25 4.36E-5
6 SGTC_3177 9107506 3.83 49.5 µM 3.34E-6 ERG2 10 6.36E-5
7 SGTC_844 0330-0132 3.70 15.3 µM 6.83E-6 21 1.08E-4
8 SGTC_973 1325-0077 3.59 65.9 µM 1.22E-5 17 1.67E-4
9 SGTC_2665 lovastatin 3.46 100.0 µM 2.30E-5 27 2.68E-4
10 SGTC_623 k072-0108 3.46 16.9 µM 2.32E-5 heme biosynthesis & mitochondrial translocase 37 2.69E-4
11 SGTC_418 lividomycin a 3.31 100.0 µM 4.96E-5 29 4.75E-4
12 SGTC_634 1611-4317 3.26 11.2 µM 6.01E-5 ERG2 35 5.47E-4
13 SGTC_1825 st052143 3.22 62.6 µM 7.43E-5 36 6.41E-4
14 SGTC_979 1426-2828 3.22 121.0 µM 7.56E-5 50 6.49E-4
15 SGTC_3189 9110682 3.19 49.5 µM 8.60E-5 62 7.15E-4
16 SGTC_372 0155-0182 3.17 15.9 µM 9.54E-5 mitochondrial response to ROS 68 7.72E-4
17 SGTC_1739 st037196 3.13 92.5 µM 1.11E-4 58 8.64E-4
18 SGTC_1851 st056236 3.07 18.9 µM 1.46E-4 48 0.00106
19 SGTC_2573 2',4'-dihydroxychalcone 3.06 15.0 µM 1.53E-4 106 0.00110
20 SGTC_763 3453-1109 3.04 128.0 µM 1.68E-4 50 0.00118

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 2.95E-11 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.106 6.42E-10 YBR210W ERV15 hom Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication
0.106 9.07E-10 YDR461W MFA1 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
0.105 9.57E-10 YGL108C YGL108C hom Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress
0.100 6.61E-9 YAL034C-B_d YAL034C-B_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.092 8.45E-8 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.17E-7 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.090 1.62E-7 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.090 2.03E-7 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.40E-7 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.089 2.40E-7 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.087 4.26E-7 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.087 4.37E-7 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.085 8.66E-7 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.084 1.05E-6 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility