YLL029W / FRA1

Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL029W / FRA1

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.63|P-value:3.06E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.59|P-value:3.51E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.36|P-value:7.43E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.82|P-value:1.56E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.94|P-value:2.78E-11 ID:SGTC_362|Compound:0310-0100|FD-Score:4.65|P-value:5.68E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.07|P-value:8.67E-7 ID:SGTC_376|Compound:3970-0862|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.37|P-value:7.24E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.81|P-value:4.48E-17 ID:SGTC_670|Compound:4204-0025|FD-Score:4.81|P-value:2.85E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.81|P-value:1.64E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.43|P-value:6.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.66|P-value:5.36E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.51|P-value:4.64E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.46|P-value:1.29E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.79|P-value:1.77E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.89|P-value:3.85E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.07|P-value:6.05E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.21|P-value:3.64E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.51|P-value:1.05E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.65|P-value:2.87E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.46|P-value:5.46E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.10|P-value:5.37E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.62|P-value:3.12E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.74|P-value:2.06E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.44|P-value:5.81E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.51|P-value:4.67E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.80|P-value:1.70E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.65|P-value:2.91E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.84|P-value:1.79E-8 ID:SGTC_2111|Compound:5486399|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:6.54E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.82|P-value:1.55E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.81|P-value:2.85E-6 ID:SGTC_2205|Compound:7238770|FD-Score:4.07|P-value:6.11E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.97|P-value:8.95E-9 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.55|P-value:8.78E-6 ID:SGTC_2696|Compound:st077691|FD-Score:4.01|P-value:7.78E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.54|P-value:4.27E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-5.40|P-value:1.76E-7 ID:SGTC_2923|Compound:7992654|FD-Score:3.63|P-value:2.99E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.90|P-value:1.14E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.44|P-value:5.87E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.63|P-value:3.11E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.43|P-value:6.07E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.63|P-value:3.06E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.59|P-value:3.51E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.36|P-value:7.43E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.82|P-value:1.56E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.94|P-value:2.78E-11 ID:SGTC_362|Compound:0310-0100|FD-Score:4.65|P-value:5.68E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.07|P-value:8.67E-7 ID:SGTC_376|Compound:3970-0862|FD-Score:3.51|P-value:4.53E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.37|P-value:7.24E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.81|P-value:4.48E-17 ID:SGTC_670|Compound:4204-0025|FD-Score:4.81|P-value:2.85E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.81|P-value:1.64E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.43|P-value:6.01E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.66|P-value:5.36E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.51|P-value:4.64E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.46|P-value:1.29E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.79|P-value:1.77E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.89|P-value:3.85E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.07|P-value:6.05E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.21|P-value:3.64E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.51|P-value:1.05E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.65|P-value:2.87E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.46|P-value:5.46E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.10|P-value:5.37E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.62|P-value:3.12E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.74|P-value:2.06E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.44|P-value:5.81E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.51|P-value:4.67E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.80|P-value:1.70E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.65|P-value:2.91E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-5.84|P-value:1.79E-8 ID:SGTC_2111|Compound:5486399|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:6.54E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.82|P-value:1.55E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.81|P-value:2.85E-6 ID:SGTC_2205|Compound:7238770|FD-Score:4.07|P-value:6.11E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.97|P-value:8.95E-9 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.55|P-value:8.78E-6 ID:SGTC_2696|Compound:st077691|FD-Score:4.01|P-value:7.78E-5 ID:SGTC_2836|Compound:9010338|FD-Score:-3.54|P-value:4.27E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.58|P-value:3.68E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-5.40|P-value:1.76E-7 ID:SGTC_2923|Compound:7992654|FD-Score:3.63|P-value:2.99E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.90|P-value:1.14E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.44|P-value:5.87E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.63|P-value:3.11E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.43|P-value:6.07E-4

Top fitness defect scores for YLL029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_513 4245-1575 8.81 41.7 µM 4.48E-17 unfolded protein response 21 6.15E-19
2 SGTC_236 1509-0011 6.94 5.3 µM 2.78E-11 268 1.90E-12
3 SGTC_1213 1315-0166 6.89 115.0 µM 3.85E-11 9 2.75E-12
4 SGTC_2681 menadione 5.97 3.2 µM 8.95E-9 superoxide 10 1.22E-9
5 SGTC_2177 5811945 4.81 192.0 µM 2.85E-6 13 7.70E-7
6 SGTC_670 4204-0025 4.81 119.0 µM 2.85E-6 copper-dependent oxidative stress 16 7.70E-7
7 SGTC_1150 3909-7983 4.66 10.9 µM 5.36E-6 12 1.56E-6
8 SGTC_362 0310-0100 4.65 9.0 µM 5.68E-6 RPP1 & pyrimidine depletion 17 1.66E-6
9 SGTC_2682 pyrogallin 4.55 40.0 µM 8.78E-6 copper-dependent oxidative stress 17 2.71E-6
10 SGTC_1193 1488-0126 4.46 41.5 µM 1.29E-5 18 4.16E-6
11 SGTC_1510 1123-0200 4.10 71.5 µM 5.37E-5 39 2.05E-5
12 SGTC_1239 0337-0584 4.07 35.4 µM 6.05E-5 unfolded protein response 47 2.34E-5
13 SGTC_2205 7238770 4.07 200.0 µM 6.11E-5 4 2.36E-5
14 SGTC_2696 st077691 4.01 74.3 µM 7.78E-5 32 3.09E-5
15 SGTC_3044 9093193 3.90 49.5 µM 1.14E-4 25 4.75E-5
16 SGTC_235 0330-0087 3.82 5.0 mM 1.56E-4 TSC3-RPN4 30 6.73E-5
17 SGTC_1712 st032288 3.74 53.4 µM 2.06E-4 calcium & mitochondrial duress 204 9.16E-5
18 SGTC_2111 5486399 3.74 200.0 µM 2.10E-4 58 9.36E-5
19 SGTC_1276 0871-0068 3.65 94.2 µM 2.87E-4 21 1.32E-4
20 SGTC_2923 7992654 3.63 58.1 µM 2.99E-4 Golgi 39 1.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 7.08E-34 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.207 9.88E-34 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.203 1.24E-32 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.203 1.89E-32 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.202 3.31E-32 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.191 9.11E-29 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.188 5.78E-28 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.185 2.61E-27 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.185 3.26E-27 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.182 2.02E-26 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.182 2.03E-26 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.181 4.38E-26 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.180 8.80E-26 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.177 4.17E-25 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.170 3.77E-23 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase