YLL033W / IRC19

Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL033W / IRC19

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.71|P-value:4.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.03|P-value:9.76E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.61|P-value:2.10E-9 ID:SGTC_211|Compound:3455-0679|FD-Score:3.48|P-value:1.22E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.03|P-value:6.81E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.70|P-value:1.17E-60 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.78|P-value:7.22E-10 ID:SGTC_279|Compound:1273-0055|FD-Score:3.05|P-value:6.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.37|P-value:2.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.04|P-value:9.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.83|P-value:5.35E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.40|P-value:3.07E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.16|P-value:6.20E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.96|P-value:2.39E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-4.40|P-value:3.09E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.42|P-value:2.28E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.37|P-value:1.93E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.74|P-value:4.20E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.22|P-value:4.91E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.91|P-value:1.98E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.57|P-value:8.41E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.94|P-value:9.53E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.09|P-value:5.57E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.78|P-value:3.53E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.73|P-value:4.39E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.35|P-value:2.47E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.61|P-value:7.06E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.93|P-value:9.97E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.35|P-value:2.99E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.16|P-value:4.29E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.78|P-value:2.65E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:5.57E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.01|P-value:7.39E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.97|P-value:8.65E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.71|P-value:4.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.03|P-value:9.76E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.61|P-value:2.10E-9 ID:SGTC_211|Compound:3455-0679|FD-Score:3.48|P-value:1.22E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.03|P-value:6.81E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.70|P-value:1.17E-60 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.78|P-value:7.22E-10 ID:SGTC_279|Compound:1273-0055|FD-Score:3.05|P-value:6.50E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.37|P-value:2.83E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.04|P-value:9.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.83|P-value:5.35E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.40|P-value:3.07E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.16|P-value:6.20E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.96|P-value:2.39E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-4.40|P-value:3.09E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.42|P-value:2.28E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.37|P-value:1.93E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.74|P-value:4.20E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.22|P-value:4.91E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.91|P-value:1.98E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.57|P-value:8.41E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.94|P-value:9.53E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.09|P-value:5.57E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.78|P-value:3.53E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.43|P-value:1.52E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.73|P-value:4.39E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.35|P-value:2.47E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.61|P-value:7.06E-5 ID:SGTC_1891|Compound:st059073|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.93|P-value:9.97E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.35|P-value:2.99E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.16|P-value:4.29E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.19|P-value:3.80E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.78|P-value:2.65E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:5.57E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.01|P-value:7.39E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.97|P-value:8.65E-4

Top fitness defect scores for YLL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.70 5.3 µM 1.17E-60 90 5.02E-56
2 SGTC_310 1273-0058 9.83 1.1 µM 5.35E-25 mitochondrial stress 43 4.30E-23
3 SGTC_275 trichlorophene 5.78 5.7 µM 7.22E-10 mitochondrial stress 126 3.84E-9
4 SGTC_173 1273-0061 5.61 2.7 µM 2.10E-9 mitochondrial stress 119 1.03E-8
5 SGTC_2638 epoxomicin 4.78 18.0 µM 2.65E-7 16 8.82E-7
6 SGTC_1882 5615643 4.35 20.0 µM 2.47E-6 TRP & mitochondrial translation 20 6.86E-6
7 SGTC_886 0866-0150 3.91 153.0 µM 1.98E-5 25 4.67E-5
8 SGTC_1351 1496-0003 3.78 46.5 µM 3.53E-5 24 7.94E-5
9 SGTC_832 4083-0019 3.74 164.0 µM 4.20E-5 translation 110 9.32E-5
10 SGTC_1742 st038235 3.73 28.9 µM 4.39E-5 mitochondrial stress 123 9.70E-5
11 SGTC_70 0141-0289 3.71 43.3 µM 4.62E-5 mitochondrial stress 193 1.02E-4
12 SGTC_2688 kanamycin b 3.67 96.7 µM 5.57E-5 calcium & mitochondrial duress 412 1.21E-4
13 SGTC_1883 5-benzylidenerhodanine 3.61 20.0 µM 7.06E-5 TRP & mitochondrial translation 88 1.50E-4
14 SGTC_314 1671-0008 3.59 2.7 µM 7.85E-5 70 1.66E-4
15 SGTC_1201 1889-3372 3.57 45.9 µM 8.41E-5 Golgi 16 1.76E-4
16 SGTC_211 3455-0679 3.48 143.5 µM 1.22E-4 34 2.48E-4
17 SGTC_1551 6-bromo-3'-methylflavone 3.43 63.5 µM 1.52E-4 39 3.03E-4
18 SGTC_2107 5363541 3.41 170.2 µM 1.66E-4 20 3.30E-4
19 SGTC_767 0929-0023 3.37 86.0 µM 1.93E-4 TRP & mitochondrial translation 119 3.79E-4
20 SGTC_1891 st059073 3.32 26.2 µM 2.32E-4 TSC3-RPN4 39 4.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 1.24E-247 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.533 6.32E-246 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.520 4.98E-232 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.509 1.68E-220 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.498 4.33E-210 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.496 4.42E-208 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.491 2.66E-203 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.491 5.55E-202 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.479 3.30E-192 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.478 3.41E-191 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.465 7.46E-180 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.461 4.92E-176 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.460 8.53E-175 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.459 1.84E-174 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.457 3.04E-173 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein