YLL038C / ENT4

Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL038C / ENT4

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.92|P-value:1.12E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.49|P-value:6.68E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:2.46|P-value:9.12E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.88|P-value:1.33E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-2.71|P-value:3.05E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.72|P-value:2.93E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.64|P-value:4.13E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.70|P-value:3.25E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.98|P-value:8.40E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-2.69|P-value:3.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.18|P-value:2.93E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.87|P-value:1.40E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.94|P-value:3.12E-7 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.61|P-value:4.82E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.40|P-value:8.63E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.10|P-value:1.07E-7 ID:SGTC_898|Compound:1000-0849|FD-Score:3.94|P-value:3.16E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:2.47|P-value:8.98E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.02|P-value:1.92E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:3.16|P-value:3.20E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.52|P-value:7.31E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:2.47E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.82|P-value:1.85E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.44|P-value:9.94E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.59|P-value:5.30E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.45|P-value:9.93E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-2.53|P-value:6.88E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.45|P-value:9.58E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:3.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.59|P-value:5.22E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-2.69|P-value:3.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.92|P-value:1.10E-4 ID:SGTC_1747|Compound:st037496|FD-Score:2.99|P-value:7.70E-5 ID:SGTC_1895|Compound:st058434|FD-Score:2.60|P-value:5.10E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.77|P-value:2.35E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-2.70|P-value:3.16E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.73|P-value:2.81E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.16|P-value:3.24E-5 ID:SGTC_2103|Compound:5378138|FD-Score:4.00|P-value:2.05E-7 ID:SGTC_2108|Compound:5365811|FD-Score:5.09|P-value:6.32E-11 ID:SGTC_2113|Compound:5491891|FD-Score:-2.65|P-value:4.01E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.23|P-value:2.26E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.12|P-value:3.87E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.19|P-value:2.73E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.58|P-value:5.65E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.52|P-value:7.08E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:1.05E-6 ID:SGTC_2678|Compound:equilin|FD-Score:2.57|P-value:5.80E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.71|P-value:3.09E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.53|P-value:6.91E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.93|P-value:1.08E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.20|P-value:2.59E-5 ID:SGTC_2896|Compound:9052656|FD-Score:2.76|P-value:2.45E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.06|P-value:1.38E-7 ID:SGTC_3049|Compound:9092223|FD-Score:-2.50|P-value:7.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.19|P-value:2.70E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.35|P-value:1.12E-5 ID:SGTC_3162|Compound:9099653|FD-Score:2.72|P-value:2.92E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.52|P-value:7.25E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.07|P-value:5.15E-5 ID:SGTC_3222|Compound:9128301|FD-Score:2.47|P-value:9.08E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.61|P-value:4.90E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:2.92|P-value:1.12E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.49|P-value:6.68E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:2.46|P-value:9.12E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.88|P-value:1.33E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-2.71|P-value:3.05E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.72|P-value:2.93E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.64|P-value:4.13E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.70|P-value:3.25E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.98|P-value:8.40E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:-2.69|P-value:3.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.18|P-value:2.93E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.87|P-value:1.40E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.94|P-value:3.12E-7 ID:SGTC_885|Compound:0865-0106|FD-Score:-2.61|P-value:4.82E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.40|P-value:8.63E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.10|P-value:1.07E-7 ID:SGTC_898|Compound:1000-0849|FD-Score:3.94|P-value:3.16E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:2.47|P-value:8.98E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.02|P-value:1.92E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:3.16|P-value:3.20E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.52|P-value:7.31E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:2.47E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.82|P-value:1.85E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.44|P-value:9.94E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.59|P-value:5.30E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.45|P-value:9.93E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-2.53|P-value:6.88E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.45|P-value:9.58E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:3.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.59|P-value:5.22E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-2.69|P-value:3.32E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.92|P-value:1.10E-4 ID:SGTC_1747|Compound:st037496|FD-Score:2.99|P-value:7.70E-5 ID:SGTC_1895|Compound:st058434|FD-Score:2.60|P-value:5.10E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.77|P-value:2.35E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-2.70|P-value:3.16E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.73|P-value:2.81E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.16|P-value:3.24E-5 ID:SGTC_2103|Compound:5378138|FD-Score:4.00|P-value:2.05E-7 ID:SGTC_2108|Compound:5365811|FD-Score:5.09|P-value:6.32E-11 ID:SGTC_2113|Compound:5491891|FD-Score:-2.65|P-value:4.01E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.23|P-value:2.26E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.12|P-value:3.87E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.19|P-value:2.73E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.58|P-value:5.65E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.52|P-value:7.08E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:1.05E-6 ID:SGTC_2678|Compound:equilin|FD-Score:2.57|P-value:5.80E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.71|P-value:3.09E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.53|P-value:6.91E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.93|P-value:1.08E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.20|P-value:2.59E-5 ID:SGTC_2896|Compound:9052656|FD-Score:2.76|P-value:2.45E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-4.06|P-value:1.38E-7 ID:SGTC_3049|Compound:9092223|FD-Score:-2.50|P-value:7.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.19|P-value:2.70E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.35|P-value:1.12E-5 ID:SGTC_3162|Compound:9099653|FD-Score:2.72|P-value:2.92E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.52|P-value:7.25E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.07|P-value:5.15E-5 ID:SGTC_3222|Compound:9128301|FD-Score:2.47|P-value:9.08E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-2.61|P-value:4.90E-4

Top fitness defect scores for YLL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2108 5365811 5.09 200.0 µM 6.32E-11 1 1.83E-7
2 SGTC_39 0986-0283 4.49 58.4 µM 6.68E-9 calcium & mitochondrial duress 20 3.52E-6
3 SGTC_896 0964-0007 4.10 44.5 µM 1.07E-7 13 2.05E-5
4 SGTC_2103 5378138 4.00 10.0 µM 2.05E-7 15 3.11E-5
5 SGTC_875 0709-0210 3.94 25.7 µM 3.12E-7 fatty acid desaturase (OLE1) 31 4.07E-5
6 SGTC_898 1000-0849 3.94 28.3 µM 3.16E-7 6 4.09E-5
7 SGTC_2651 1327-0036 3.75 5.0 µM 1.05E-6 177 8.83E-5
8 SGTC_2402 5553605 3.23 200.0 µM 2.26E-5 66 6.29E-4
9 SGTC_2588 indole-3-carbinol 3.19 100.0 µM 2.73E-5 90 7.09E-4
10 SGTC_932 2857-0803 3.16 154.0 µM 3.20E-5 61 7.86E-4
11 SGTC_2056 5235370 3.16 200.0 µM 3.24E-5 76 7.93E-4
12 SGTC_2444 5485484 3.12 36.4 µM 3.87E-5 74 8.89E-4
13 SGTC_3198 9112019 3.07 49.5 µM 5.15E-5 mitochondrial processes 47 0.00107
14 SGTC_1747 st037496 2.99 66.6 µM 7.70E-5 63 0.00138
15 SGTC_418 lividomycin a 2.98 100.0 µM 8.40E-5 49 0.00146
16 SGTC_2799 7812892 2.93 81.8 µM 1.08E-4 superoxide 75 0.00172
17 SGTC_1744 st037937 2.92 38.9 µM 1.10E-4 78 0.00174
18 SGTC_38 0929-0051 2.92 58.3 µM 1.12E-4 80 0.00176
19 SGTC_843 0310-0051 2.87 143.0 µM 1.40E-4 61 0.00204
20 SGTC_2896 9052656 2.76 71.4 µM 2.45E-4 endomembrane recycling 238 0.00292

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 3.07E-42 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.224 2.16E-39 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.210 7.04E-35 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.208 5.88E-34 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.205 3.01E-33 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.186 1.86E-27 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.178 2.04E-25 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.176 9.39E-25 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.174 2.77E-24 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.173 8.25E-24 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.172 1.03E-23 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.171 1.73E-23 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.168 1.26E-22 YML107C PML39 hom Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
0.164 1.26E-21 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.157 4.99E-20 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p