YLL039C / UBI4

Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL039C / UBI4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.33|P-value:7.55E-9 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.32|P-value:8.32E-9 ID:SGTC_271|Compound:rotenone|FD-Score:-4.43|P-value:2.41E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.07|P-value:5.09E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.72|P-value:2.66E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:2.93E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.06|P-value:8.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.57|P-value:1.78E-9 ID:SGTC_331|Compound:k048-0133|FD-Score:-5.02|P-value:1.08E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:3.44|P-value:1.20E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.19|P-value:5.32E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.34|P-value:3.81E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.10|P-value:7.40E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:2.96|P-value:7.45E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-5.21|P-value:3.63E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:3.88E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.33|P-value:1.99E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:9.76E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.33|P-value:3.19E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.33|P-value:1.82E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.11|P-value:4.28E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.40|P-value:1.42E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.00|P-value:6.48E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.63|P-value:5.45E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.83|P-value:5.56E-21 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.20|P-value:3.87E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.92|P-value:1.45E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.20|P-value:5.09E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.06|P-value:8.47E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.96|P-value:7.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:9.51E-5 ID:SGTC_2255|Compound:7941087|FD-Score:2.97|P-value:7.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.48|P-value:1.03E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.76|P-value:2.13E-7 ID:SGTC_2336|Compound:9001819|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.63|P-value:8.66E-7 ID:SGTC_2475|Compound:5812728|FD-Score:-3.21|P-value:5.06E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.34|P-value:3.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.23|P-value:1.81E-18 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.25|P-value:4.34E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.30|P-value:4.54E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.40|P-value:1.38E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.00|P-value:6.52E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.24|P-value:4.45E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.13|P-value:6.56E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:5.31E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-4.48|P-value:1.87E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.05|P-value:9.04E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.33|P-value:7.55E-9 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.37|P-value:2.67E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.32|P-value:8.32E-9 ID:SGTC_271|Compound:rotenone|FD-Score:-4.43|P-value:2.41E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.07|P-value:5.09E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.72|P-value:2.66E-7 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.35|P-value:2.93E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.06|P-value:8.70E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.57|P-value:1.78E-9 ID:SGTC_331|Compound:k048-0133|FD-Score:-5.02|P-value:1.08E-7 ID:SGTC_333|Compound:3486-0131|FD-Score:3.44|P-value:1.20E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.19|P-value:5.32E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.34|P-value:3.81E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.10|P-value:7.40E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:2.96|P-value:7.45E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-5.21|P-value:3.63E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:3.88E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.33|P-value:1.99E-6 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:9.76E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.33|P-value:3.19E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.33|P-value:1.82E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.11|P-value:4.28E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.40|P-value:1.42E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.00|P-value:6.48E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.63|P-value:5.45E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.83|P-value:5.56E-21 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.20|P-value:3.87E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.92|P-value:1.45E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.20|P-value:5.09E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.06|P-value:8.47E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.96|P-value:7.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:9.51E-5 ID:SGTC_2255|Compound:7941087|FD-Score:2.97|P-value:7.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.48|P-value:1.03E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.76|P-value:2.13E-7 ID:SGTC_2336|Compound:9001819|FD-Score:-3.40|P-value:2.39E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.63|P-value:8.66E-7 ID:SGTC_2475|Compound:5812728|FD-Score:-3.21|P-value:5.06E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.34|P-value:3.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.23|P-value:1.81E-18 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.25|P-value:4.34E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-4.30|P-value:4.54E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.40|P-value:1.38E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.00|P-value:6.52E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.24|P-value:4.45E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.13|P-value:6.56E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:5.31E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-4.48|P-value:1.87E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.05|P-value:9.04E-4

Top fitness defect scores for YLL039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 8.83 2.4 µM 5.56E-21 endomembrane recycling 55 5.15E-19
2 SGTC_2582 agaric acid 8.23 100.0 µM 1.81E-18 redox potentiating 99 9.70E-17
3 SGTC_310 1273-0058 5.57 1.1 µM 1.78E-9 mitochondrial stress 157 1.30E-8
4 SGTC_58 0957-0393 5.33 9.0 µM 7.55E-9 cell wall 253 4.79E-8
5 SGTC_159 3970-0959 5.32 50.0 µM 8.32E-9 33 5.23E-8
6 SGTC_2335 9018011 4.76 154.2 µM 2.13E-7 16 9.77E-7
7 SGTC_290 2043-6722 4.72 48.1 µM 2.66E-7 2 1.19E-6
8 SGTC_1309 pyrazolanthrone 4.33 13.4 µM 1.99E-6 17 7.30E-6
9 SGTC_1844 rapamycin 4.20 4.0 nM 3.87E-6 145 1.33E-5
10 SGTC_2014 4013930 3.92 200.0 µM 1.45E-5 32 4.38E-5
11 SGTC_1271 0832-2808 3.70 169.0 µM 3.88E-5 17 1.06E-4
12 SGTC_2989 9073649 3.63 71.4 µM 5.31E-5 52 1.41E-4
13 SGTC_1688 st021091 3.63 57.6 µM 5.45E-5 10 1.44E-4
14 SGTC_2129 girgensonine 3.49 121.0 µM 9.51E-5 heme biosynthesis & mitochondrial translocase 51 2.38E-4
15 SGTC_2282 7944268 3.48 200.0 µM 1.03E-4 RPP1 & pyrimidine depletion 54 2.55E-4
16 SGTC_365 0121-0052 3.46 13.6 µM 1.08E-4 mitochondrial response to ROS 83 2.68E-4
17 SGTC_333 3486-0131 3.44 40.1 µM 1.20E-4 amide catabolism 19 2.94E-4
18 SGTC_2679 rapamycin 3.40 1.0 nM 1.38E-4 184 3.33E-4
19 SGTC_1607 st000305 3.40 50.6 µM 1.42E-4 31 3.41E-4
20 SGTC_1522 st012842 3.33 45.6 µM 1.82E-4 RNA pol III & RNase P/MRP 51 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.271 2.35E-57 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.252 1.00E-49 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.251 2.57E-49 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.238 1.53E-44 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.237 3.21E-44 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.234 6.19E-43 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.227 2.77E-40 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.223 3.27E-39 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.218 1.66E-37 YFR019W FAB1 hom 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
0.213 9.77E-36 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.207 7.03E-34 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.201 5.63E-32 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.199 2.85E-31 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.192 3.46E-29 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.191 6.20E-29 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1