HIPHOP chemogenomics database

YLL043W / FPS1

Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YLL043W / FPS1

Click on Significant Values for Screen Details

Top fitness defect scores for YLL043W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_138	0850-0259	24.00	40.9 µM	2.55E-123	cell wall	3	2.45E-127
2	SGTC_2912	7964298	19.80	10.9 µM	7.44E-85	cell wall	5	1.46E-87
3	SGTC_1844	rapamycin	17.80	4.0 nM	9.70E-69		9	6.70E-71
4	SGTC_360	0957-0399	16.50	1.0 µM	7.98E-60	cell wall	3	1.10E-61
5	SGTC_58	0957-0393	12.80	9.0 µM	6.35E-37	cell wall	41	5.11E-38
6	SGTC_586	0957-0265	11.40	8.2 µM	2.36E-29	cell wall	4	3.37E-30
7	SGTC_2679	rapamycin	10.70	1.0 nM	2.67E-26		20	4.81E-27
8	SGTC_354	2783-3500	8.81	4.9 µM	1.88E-18	cell wall	6	6.08E-19
9	SGTC_1803	st050068	8.54	52.4 µM	1.94E-17	NEO1-PIK1	32	6.77E-18
10	SGTC_2016	5121758	7.64	140.0 µM	2.49E-14	redox potentiating	6	1.09E-14
11	SGTC_839	0122-0028	7.46	230.0 µM	9.73E-14	RSC complex & mRNA processing	2	4.44E-14
12	SGTC_2323	6148992	6.91	148.3 µM	4.80E-12		5	2.48E-12
13	SGTC_2619	obliquin	6.89	87.9 µM	5.45E-12	cell wall	61	2.82E-12
14	SGTC_3331	9141060	6.88	2.0 µM	5.88E-12	cell wall	7	3.05E-12
15	SGTC_2129	girgensonine	6.86	121.0 µM	6.51E-12	heme biosynthesis & mitochondrial translocase	8	3.39E-12
16	SGTC_1800	st050079	6.75	29.1 µM	1.39E-11	NEO1-PIK1	29	7.41E-12
17	SGTC_157	1348-1695	6.66	65.8 µM	2.56E-11	iron homeostasis	18	1.39E-11
18	SGTC_1801	st050089	6.62	28.4 µM	3.31E-11	NEO1-PIK1	42	1.81E-11
19	SGTC_951	1171-0579	6.47	82.7 µM	8.74E-11	cell wall	27	4.93E-11
20	SGTC_2696	st077691	6.33	74.3 µM	2.15E-10		4	1.25E-10

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.503	4.82E-215	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.435	7.67E-155	YBR091C	TIM12	het	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.427	4.98E-149	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.422	2.28E-145	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.409	9.98E-136	YDR348C	PAL1	hom	Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.403	6.41E-131	YBL061C	SKT5	hom	Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.373	1.35E-111	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.370	1.17E-109	YGR163W	GTR2	hom	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.367	8.78E-108	YPR165W	RHO1	het	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.351	9.82E-98	YBR077C	SLM4	hom	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.351	9.17E-98	YNL233W	BNI4	hom	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.350	1.47E-97	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.347	2.01E-95	YJL081C	ARP4	het	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.346	3.28E-95	YLR332W	MID2	hom	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.341	4.99E-92	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB