HIPHOP chemogenomics database

YLL045C / RPL8B

Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YLL045C / RPL8B

Click on Significant Values for Screen Details

Top fitness defect scores for YLL045C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2688	kanamycin b	9.37	96.7 µM	4.22E-20	calcium & mitochondrial duress	37	3.71E-21
2	SGTC_3148	9097893	8.34	49.5 µM	2.31E-16		4	3.61E-17
3	SGTC_3202	9113761	6.41	49.5 µM	1.90E-10		8	7.22E-11
4	SGTC_3017	9080681	5.45	49.5 µM	4.72E-8		3	2.51E-8
5	SGTC_611	3453-1652	4.97	23.7 µM	5.36E-7		9	3.29E-7
6	SGTC_118	0083-0097	4.76	135.3 µM	1.51E-6	translation	71	9.82E-7
7	SGTC_130	0136-0219	4.68	337.7 µM	2.17E-6		12	1.44E-6
8	SGTC_1835	st008666	4.58	49.2 µM	3.38E-6		16	2.30E-6
9	SGTC_1580	hydrocortisone 21-hemisuccinate	4.46	43.2 µM	5.90E-6		13	4.14E-6
10	SGTC_1577	3(2'-chlorophenyl)-7-ethoxycoumarin	4.40	66.5 µM	7.64E-6		12	5.44E-6
11	SGTC_3122	9126309	4.18	49.5 µM	1.96E-5	cell wall signaling	5	1.47E-5
12	SGTC_2461	5755302	4.17	26.1 µM	2.07E-5		28	1.55E-5
13	SGTC_1351	1496-0003	4.11	46.5 µM	2.65E-5		18	2.02E-5
14	SGTC_1724	st037281	3.99	8.3 µM	4.16E-5		43	3.25E-5
15	SGTC_2947	9072639	3.77	7.7 µM	1.00E-4	tubulin folding & SWR complex	52	8.18E-5
16	SGTC_906	1165-0455	3.75	526.0 µM	1.06E-4		15	8.69E-5
17	SGTC_2399	5884133	3.67	200.0 µM	1.44E-4	cell wall signaling	82	1.20E-4
18	SGTC_1176	0848-0131	3.49	83.3 µM	2.80E-4	Golgi	33	2.41E-4
19	SGTC_2558	carylophyllene oxide	3.46	100.0 µM	3.15E-4		28	2.73E-4
20	SGTC_2557	derrustone	3.44	83.8 µM	3.30E-4		52	2.86E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.202	2.73E-32	YLR367W	RPS22B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.195	4.36E-30	YBR048W	RPS11B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.178	3.41E-25	YDL082W	RPL13A	hom	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.174	4.13E-24	YHL033C	RPL8A	hom	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.164	9.26E-22	YLR185W	RPL37A	hom	Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.161	6.81E-21	YFR031C-A	RPL2A	hom	Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.160	1.49E-20	YJL177W	RPL17B	hom	Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication
0.149	4.30E-18	YGL246C	RAI1	hom	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.149	3.92E-18	YBR287W_p	YBR287W_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.145	2.56E-17	YOR001W	RRP6	hom	Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.144	4.38E-17	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.141	2.17E-16	YEL054C	RPL12A	hom	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.137	1.97E-15	YKL061W_p	BLI1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.136	2.04E-15	YDR447C	RPS17B	hom	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.134	7.10E-15	YDR500C	RPL37B	hom	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication