YLL045C / RPL8B

Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL045C / RPL8B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.76|P-value:1.51E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.79|P-value:1.84E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.68|P-value:2.17E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.20|P-value:7.55E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.97|P-value:5.36E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:6.01E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.15|P-value:8.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.18|P-value:4.23E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.49|P-value:2.80E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.11|P-value:2.65E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.81|P-value:1.71E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.40|P-value:7.64E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.46|P-value:5.90E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.18|P-value:4.15E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.66|P-value:2.99E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.99|P-value:4.16E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.34|P-value:8.92E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.58|P-value:3.38E-6 ID:SGTC_1843|Compound:st055809|FD-Score:-8.29|P-value:1.54E-15 ID:SGTC_2078|Compound:5212016|FD-Score:-3.45|P-value:6.21E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.17|P-value:2.07E-5 ID:SGTC_2468|Compound:5987765|FD-Score:-3.54|P-value:4.54E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-4.14|P-value:4.84E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.44|P-value:3.30E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.46|P-value:3.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:2.50E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.60|P-value:7.17E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.37|P-value:4.22E-20 ID:SGTC_2694|Compound:st077685|FD-Score:3.25|P-value:6.50E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.71|P-value:2.50E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.98|P-value:9.24E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.40|P-value:7.40E-4 ID:SGTC_3017|Compound:9080681|FD-Score:5.45|P-value:4.72E-8 ID:SGTC_3018|Compound:9082602|FD-Score:-5.01|P-value:1.10E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.66|P-value:2.98E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.34|P-value:8.86E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-4.27|P-value:2.90E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.49|P-value:5.37E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_3122|Compound:9126309|FD-Score:4.18|P-value:1.96E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.35|P-value:8.66E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.34|P-value:2.31E-16 ID:SGTC_3152|Compound:9099253|FD-Score:-7.32|P-value:1.71E-12 ID:SGTC_3197|Compound:9113331|FD-Score:-4.34|P-value:2.15E-5 ID:SGTC_3202|Compound:9113761|FD-Score:6.41|P-value:1.90E-10 ID:SGTC_3328|Compound:9140624|FD-Score:-3.54|P-value:4.55E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.76|P-value:1.51E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.79|P-value:1.84E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.68|P-value:2.17E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.20|P-value:7.55E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.97|P-value:5.36E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:6.01E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.15|P-value:8.97E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.18|P-value:4.23E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.49|P-value:2.80E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.11|P-value:2.65E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.81|P-value:1.71E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.40|P-value:7.64E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.46|P-value:5.90E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.18|P-value:4.15E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.66|P-value:2.99E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.99|P-value:4.16E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.34|P-value:8.92E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.58|P-value:3.38E-6 ID:SGTC_1843|Compound:st055809|FD-Score:-8.29|P-value:1.54E-15 ID:SGTC_2078|Compound:5212016|FD-Score:-3.45|P-value:6.21E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.67|P-value:1.44E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.17|P-value:2.07E-5 ID:SGTC_2468|Compound:5987765|FD-Score:-3.54|P-value:4.54E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-4.14|P-value:4.84E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.44|P-value:3.30E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.46|P-value:3.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:2.50E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.60|P-value:7.17E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.37|P-value:4.22E-20 ID:SGTC_2694|Compound:st077685|FD-Score:3.25|P-value:6.50E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.77|P-value:1.00E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-3.71|P-value:2.50E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.98|P-value:9.24E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_3014|Compound:9081533|FD-Score:-3.40|P-value:7.40E-4 ID:SGTC_3017|Compound:9080681|FD-Score:5.45|P-value:4.72E-8 ID:SGTC_3018|Compound:9082602|FD-Score:-5.01|P-value:1.10E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.66|P-value:2.98E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.34|P-value:8.86E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-4.27|P-value:2.90E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.49|P-value:5.37E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_3122|Compound:9126309|FD-Score:4.18|P-value:1.96E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.35|P-value:8.66E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.34|P-value:2.31E-16 ID:SGTC_3152|Compound:9099253|FD-Score:-7.32|P-value:1.71E-12 ID:SGTC_3197|Compound:9113331|FD-Score:-4.34|P-value:2.15E-5 ID:SGTC_3202|Compound:9113761|FD-Score:6.41|P-value:1.90E-10 ID:SGTC_3328|Compound:9140624|FD-Score:-3.54|P-value:4.55E-4

Top fitness defect scores for YLL045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 9.37 96.7 µM 4.22E-20 calcium & mitochondrial duress 37 3.71E-21
2 SGTC_3148 9097893 8.34 49.5 µM 2.31E-16 4 3.61E-17
3 SGTC_3202 9113761 6.41 49.5 µM 1.90E-10 8 7.22E-11
4 SGTC_3017 9080681 5.45 49.5 µM 4.72E-8 3 2.51E-8
5 SGTC_611 3453-1652 4.97 23.7 µM 5.36E-7 9 3.29E-7
6 SGTC_118 0083-0097 4.76 135.3 µM 1.51E-6 translation 71 9.82E-7
7 SGTC_130 0136-0219 4.68 337.7 µM 2.17E-6 12 1.44E-6
8 SGTC_1835 st008666 4.58 49.2 µM 3.38E-6 16 2.30E-6
9 SGTC_1580 hydrocortisone 21-hemisuccinate 4.46 43.2 µM 5.90E-6 13 4.14E-6
10 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.40 66.5 µM 7.64E-6 12 5.44E-6
11 SGTC_3122 9126309 4.18 49.5 µM 1.96E-5 cell wall signaling 5 1.47E-5
12 SGTC_2461 5755302 4.17 26.1 µM 2.07E-5 28 1.55E-5
13 SGTC_1351 1496-0003 4.11 46.5 µM 2.65E-5 18 2.02E-5
14 SGTC_1724 st037281 3.99 8.3 µM 4.16E-5 43 3.25E-5
15 SGTC_2947 9072639 3.77 7.7 µM 1.00E-4 tubulin folding & SWR complex 52 8.18E-5
16 SGTC_906 1165-0455 3.75 526.0 µM 1.06E-4 15 8.69E-5
17 SGTC_2399 5884133 3.67 200.0 µM 1.44E-4 cell wall signaling 82 1.20E-4
18 SGTC_1176 0848-0131 3.49 83.3 µM 2.80E-4 Golgi 33 2.41E-4
19 SGTC_2558 carylophyllene oxide 3.46 100.0 µM 3.15E-4 28 2.73E-4
20 SGTC_2557 derrustone 3.44 83.8 µM 3.30E-4 52 2.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 2.73E-32 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.195 4.36E-30 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.178 3.41E-25 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.174 4.13E-24 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.164 9.26E-22 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.161 6.81E-21 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.160 1.49E-20 YJL177W RPL17B hom Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication
0.149 4.30E-18 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.149 3.92E-18 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.145 2.56E-17 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.144 4.38E-17 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.141 2.17E-16 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.137 1.97E-15 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.136 2.04E-15 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.134 7.10E-15 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication