YLL055W / YCT1

High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL055W / YCT1

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:3.15|P-value:4.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.95|P-value:8.78E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.42|P-value:1.49E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.07|P-value:8.51E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:1.94E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.47|P-value:1.20E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.37|P-value:2.02E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:5.15|P-value:2.90E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:2.92|P-value:9.63E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.23|P-value:3.13E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.97|P-value:8.13E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.14|P-value:6.19E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.99|P-value:1.28E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.86|P-value:2.23E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.16|P-value:4.05E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.88|P-value:3.41E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.09|P-value:5.22E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.71|P-value:6.99E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.01|P-value:7.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.52|P-value:1.62E-6 ID:SGTC_1637|Compound:st007924|FD-Score:8.23|P-value:3.07E-18 ID:SGTC_1638|Compound:st008370|FD-Score:-5.92|P-value:4.96E-10 ID:SGTC_1804|Compound:st050076|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.21|P-value:4.35E-6 ID:SGTC_1853|Compound:st056710|FD-Score:2.93|P-value:9.37E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.77|P-value:5.45E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.66|P-value:8.54E-5 ID:SGTC_2295|Compound:7971645|FD-Score:4.18|P-value:5.06E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.03|P-value:6.61E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.50|P-value:1.68E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.10|P-value:7.46E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.08|P-value:5.39E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-4.07|P-value:1.44E-5 ID:SGTC_3092|Compound:9117248|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.33|P-value:3.28E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.15|P-value:4.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.95|P-value:8.78E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.42|P-value:1.49E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.07|P-value:8.51E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.56|P-value:1.29E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:1.94E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.43|P-value:2.22E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.47|P-value:1.20E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.37|P-value:2.02E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:5.15|P-value:2.90E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:2.92|P-value:9.63E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.23|P-value:3.13E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:2.97|P-value:8.13E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.14|P-value:6.19E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.99|P-value:1.28E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.86|P-value:2.23E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.16|P-value:4.05E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.88|P-value:3.41E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:8.97E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.18|P-value:5.70E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.09|P-value:5.22E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.71|P-value:6.99E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.01|P-value:7.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.52|P-value:1.62E-6 ID:SGTC_1637|Compound:st007924|FD-Score:8.23|P-value:3.07E-18 ID:SGTC_1638|Compound:st008370|FD-Score:-5.92|P-value:4.96E-10 ID:SGTC_1804|Compound:st050076|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.21|P-value:4.35E-6 ID:SGTC_1853|Compound:st056710|FD-Score:2.93|P-value:9.37E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.34|P-value:3.15E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.77|P-value:5.45E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.66|P-value:8.54E-5 ID:SGTC_2295|Compound:7971645|FD-Score:4.18|P-value:5.06E-6 ID:SGTC_2819|Compound:7996655|FD-Score:3.03|P-value:6.61E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.50|P-value:1.68E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.10|P-value:7.46E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.08|P-value:5.39E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-4.07|P-value:1.44E-5 ID:SGTC_3092|Compound:9117248|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.33|P-value:3.28E-4

Top fitness defect scores for YLL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1637 st007924 8.23 17.4 µM 3.07E-18 3 9.35E-17
2 SGTC_814 3342-0569 5.15 96.0 µM 2.90E-8 6 1.28E-7
3 SGTC_779 1360-0071 4.47 233.0 µM 1.20E-6 fatty acid desaturase (OLE1) 18 3.87E-6
4 SGTC_791 1348-1292 4.37 225.0 µM 2.02E-6 26 6.21E-6
5 SGTC_1849 st056239 4.21 19.2 µM 4.35E-6 RPP1 & pyrimidine depletion 20 1.25E-5
6 SGTC_2295 7971645 4.18 200.0 µM 5.06E-6 17 1.44E-5
7 SGTC_1070 indatraline 4.14 8.8 µM 6.19E-6 60S ribosome export 23 1.73E-5
8 SGTC_1115 galangin 3.99 695.7 nM 1.28E-5 RPP1 & pyrimidine depletion 13 3.37E-5
9 SGTC_431 k089-0097 3.90 107.0 µM 1.94E-5 iron homeostasis 46 4.91E-5
10 SGTC_1261 0712-0010 3.86 12.7 µM 2.23E-5 RNA processing & uracil transport 25 5.59E-5
11 SGTC_154 3389-1638 3.42 511.1 µM 1.49E-4 42 3.16E-4
12 SGTC_784 4579-0127 3.41 173.0 µM 1.52E-4 40 3.22E-4
13 SGTC_977 1348-1378 3.23 135.0 µM 3.13E-4 45 6.22E-4
14 SGTC_1351 1496-0003 3.16 46.5 µM 4.05E-4 44 7.88E-4
15 SGTC_84 0443-0269 3.15 128.8 µM 4.16E-4 42 8.08E-4
16 SGTC_1606 st000094 3.09 49.2 µM 5.22E-4 60S ribosome export 49 9.93E-4
17 SGTC_3084 9116877 3.08 49.5 µM 5.39E-4 23 0.00102
18 SGTC_2819 7996655 3.03 46.4 µM 6.61E-4 52 0.00123
19 SGTC_1626 st003712 3.01 1.8 µM 7.02E-4 66 0.00130
20 SGTC_1069 diphenylcyclopropenone 2.97 8.5 µM 8.13E-4 75 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 9.23E-24 YKL217W JEN1 hom Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
0.131 2.48E-14 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.106 6.20E-10 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.105 9.50E-10 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.100 6.17E-9 YHR135C YCK1 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
0.092 1.00E-7 YLR194C YLR194C hom Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
0.086 5.37E-7 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.085 7.72E-7 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.085 8.52E-7 YKL123W_d YKL123W_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
0.084 1.19E-6 YGR088W CTT1 hom Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
0.081 2.37E-6 YLR231C BNA5 hom Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.080 3.89E-6 YBL054W TOD6 hom PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication
0.079 4.02E-6 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.076 9.90E-6 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.075 1.49E-5 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data