YLL056C_p

Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL056C / YLL056C

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:2.76|P-value:9.40E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.47|P-value:8.82E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.21|P-value:2.70E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:2.77|P-value:9.04E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.12|P-value:3.97E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:3.08|P-value:2.68E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.94|P-value:7.58E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.26|P-value:2.20E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.70|P-value:1.73E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:2.89|P-value:5.87E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.26|P-value:2.15E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.96|P-value:4.93E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:2.80|P-value:8.07E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:2.98|P-value:4.13E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.12|P-value:2.12E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:3.36|P-value:8.16E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.17|P-value:1.88E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.86|P-value:6.63E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.64|P-value:2.32E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.25|P-value:2.26E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:7.41E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.06|P-value:8.46E-9 ID:SGTC_1714|Compound:st033236|FD-Score:-4.17|P-value:3.13E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-3.40|P-value:1.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.62|P-value:2.50E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.29|P-value:1.92E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.74|P-value:6.25E-8 ID:SGTC_2128|Compound:5255449|FD-Score:3.14|P-value:2.11E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.78|P-value:1.19E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.52|P-value:4.01E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.79|P-value:8.62E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.78|P-value:8.68E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.13|P-value:2.24E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.15|P-value:2.08E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.94|P-value:4.74E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.87|P-value:2.92E-8 ID:SGTC_2937|Compound:9044753|FD-Score:-3.71|P-value:3.04E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-4.57|P-value:3.58E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.27|P-value:9.23E-7 ID:SGTC_3049|Compound:9092223|FD-Score:2.97|P-value:4.18E-4 ID:SGTC_3062|Compound:9077494|FD-Score:2.93|P-value:5.06E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.83|P-value:9.27E-6 ID:SGTC_3261|Compound:9137475|FD-Score:2.88|P-value:6.11E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.61|P-value:2.63E-5 ID:SGTC_3335|Compound:9143315|FD-Score:2.85|P-value:6.69E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:2.76|P-value:9.40E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.18|P-value:2.99E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.47|P-value:8.82E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.21|P-value:2.70E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:2.77|P-value:9.04E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.12|P-value:3.97E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:3.08|P-value:2.68E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.94|P-value:7.58E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.26|P-value:2.20E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.70|P-value:1.73E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:2.89|P-value:5.87E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.26|P-value:2.15E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.96|P-value:4.93E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:2.80|P-value:8.07E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:2.98|P-value:4.13E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.12|P-value:2.12E-6 ID:SGTC_959|Compound:1222-0044|FD-Score:3.36|P-value:8.16E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.17|P-value:1.88E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.86|P-value:6.63E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.64|P-value:2.32E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.25|P-value:2.26E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:7.41E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.06|P-value:8.46E-9 ID:SGTC_1714|Compound:st033236|FD-Score:-4.17|P-value:3.13E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-3.40|P-value:1.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.62|P-value:2.50E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.29|P-value:1.92E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.74|P-value:6.25E-8 ID:SGTC_2128|Compound:5255449|FD-Score:3.14|P-value:2.11E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.78|P-value:1.19E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.52|P-value:4.01E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.79|P-value:8.62E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.78|P-value:8.68E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.13|P-value:2.24E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.95|P-value:4.54E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.15|P-value:2.08E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.94|P-value:4.74E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.87|P-value:2.92E-8 ID:SGTC_2937|Compound:9044753|FD-Score:-3.71|P-value:3.04E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-4.57|P-value:3.58E-7 ID:SGTC_2997|Compound:9067075|FD-Score:-3.14|P-value:3.53E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.27|P-value:9.23E-7 ID:SGTC_3049|Compound:9092223|FD-Score:2.97|P-value:4.18E-4 ID:SGTC_3062|Compound:9077494|FD-Score:2.93|P-value:5.06E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.83|P-value:9.27E-6 ID:SGTC_3261|Compound:9137475|FD-Score:2.88|P-value:6.11E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.16|P-value:1.94E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.61|P-value:2.63E-5 ID:SGTC_3335|Compound:9143315|FD-Score:2.85|P-value:6.69E-4

Top fitness defect scores for YLL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1565 sinapyl alcohol 5.06 95.1 µM 8.46E-9 5 2.05E-7
2 SGTC_2932 9016711 4.87 44.5 µM 2.92E-8 27 5.66E-7
3 SGTC_2024 5144227 4.74 134.0 µM 6.25E-8 21 1.06E-6
4 SGTC_3020 9089140 4.27 49.5 µM 9.23E-7 20 9.67E-6
5 SGTC_942 3253-1115 4.12 227.0 µM 2.12E-6 25 1.91E-5
6 SGTC_829 1635-0120 3.96 117.0 µM 4.93E-6 DNA damage response 39 3.82E-5
7 SGTC_3194 9111903 3.83 49.5 µM 9.27E-6 26 6.43E-5
8 SGTC_2166 5933061 3.78 31.5 µM 1.19E-5 tubulin folding & SWR complex 48 7.90E-5
9 SGTC_414 piperonyl butoxide 3.70 100.0 µM 1.73E-5 15 1.07E-4
10 SGTC_1445 4239-0156 3.64 97.7 µM 2.32E-5 38 1.37E-4
11 SGTC_1720 st037298 3.62 9.5 µM 2.50E-5 43 1.45E-4
12 SGTC_3271 9137798 3.61 49.5 µM 2.63E-5 10 1.51E-4
13 SGTC_2329 6138490 3.52 200.0 µM 4.01E-5 47 2.14E-4
14 SGTC_959 1222-0044 3.36 107.0 µM 8.16E-5 39 3.84E-4
15 SGTC_1004 4084-0029 3.17 199.0 µM 1.88E-4 54 7.63E-4
16 SGTC_3269 9137823 3.16 49.5 µM 1.94E-4 60S ribosome export 42 7.83E-4
17 SGTC_2794 7785382 3.15 27.3 µM 2.08E-4 77 8.28E-4
18 SGTC_2128 5255449 3.14 168.5 µM 2.11E-4 71 8.38E-4
19 SGTC_2520 obtusaquinone 3.13 4.7 µM 2.24E-4 47 8.80E-4
20 SGTC_274 sirtinol 3.08 40.1 µM 2.68E-4 61 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.21E-17 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.125 3.70E-13 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.121 2.01E-12 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.116 1.36E-11 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.116 1.94E-11 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.113 5.20E-11 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.111 1.05E-10 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.107 4.26E-10 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.104 1.48E-9 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.099 9.41E-9 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.098 1.15E-8 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.098 1.47E-8 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.095 3.65E-8 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.094 4.29E-8 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.090 1.82E-7 YPL248C GAL4 hom DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p