YLL058W_p

Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL058W / YLL058W

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:3.66|P-value:7.47E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.06|P-value:7.56E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.40|P-value:2.16E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.16|P-value:5.29E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:6.35|P-value:2.38E-11 ID:SGTC_369|Compound:0957-0393|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.86|P-value:3.26E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:5.24|P-value:2.88E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.59|P-value:1.00E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.96|P-value:2.05E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.23|P-value:6.15E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:3.60|P-value:9.50E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.15|P-value:5.64E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.17|P-value:5.14E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.99|P-value:1.81E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.06|P-value:7.73E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.12|P-value:6.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.50|P-value:1.45E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-4.20|P-value:6.81E-6 ID:SGTC_1629|Compound:st005085|FD-Score:4.26|P-value:5.21E-6 ID:SGTC_1636|Compound:st007707|FD-Score:5.03|P-value:9.57E-8 ID:SGTC_1930|Compound:st074634|FD-Score:4.38|P-value:2.91E-6 ID:SGTC_2065|Compound:5221596|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.57|P-value:1.15E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.44|P-value:1.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.80|P-value:4.08E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.04|P-value:8.27E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-4.61|P-value:9.40E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.06|P-value:1.30E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.19|P-value:3.90E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.07|P-value:7.31E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.09|P-value:1.15E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.34|P-value:2.70E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.16|P-value:5.38E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.61|P-value:9.08E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.96|P-value:2.06E-5 ID:SGTC_3260|Compound:9137109|FD-Score:2.99|P-value:9.62E-4 ID:SGTC_3271|Compound:9137798|FD-Score:4.58|P-value:1.05E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:3.66|P-value:7.47E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.06|P-value:7.56E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.40|P-value:2.16E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.16|P-value:5.29E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:6.35|P-value:2.38E-11 ID:SGTC_369|Compound:0957-0393|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.86|P-value:3.26E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:5.24|P-value:2.88E-8 ID:SGTC_697|Compound:0508-1955|FD-Score:3.36|P-value:2.53E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.59|P-value:1.00E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.96|P-value:2.05E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.18|P-value:4.95E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.23|P-value:6.15E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:3.60|P-value:9.50E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.15|P-value:5.64E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.79|P-value:4.40E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.17|P-value:5.14E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.99|P-value:1.81E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.06|P-value:7.73E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.12|P-value:6.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.50|P-value:1.45E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-4.20|P-value:6.81E-6 ID:SGTC_1629|Compound:st005085|FD-Score:4.26|P-value:5.21E-6 ID:SGTC_1636|Compound:st007707|FD-Score:5.03|P-value:9.57E-8 ID:SGTC_1930|Compound:st074634|FD-Score:4.38|P-value:2.91E-6 ID:SGTC_2065|Compound:5221596|FD-Score:3.49|P-value:1.49E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.57|P-value:1.15E-6 ID:SGTC_2072|Compound:5231554|FD-Score:3.19|P-value:4.74E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.44|P-value:1.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.80|P-value:4.08E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-3.04|P-value:8.27E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-4.61|P-value:9.40E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.06|P-value:1.30E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.19|P-value:3.90E-8 ID:SGTC_2783|Compound:7738165|FD-Score:3.07|P-value:7.31E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.09|P-value:1.15E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.34|P-value:2.70E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.16|P-value:5.38E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.61|P-value:9.08E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.96|P-value:2.06E-5 ID:SGTC_3260|Compound:9137109|FD-Score:2.99|P-value:9.62E-4 ID:SGTC_3271|Compound:9137798|FD-Score:4.58|P-value:1.05E-6

Top fitness defect scores for YLL058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_348 k064-0012 6.35 10.7 µM 2.38E-11 60S ribosome export 4 1.06E-10
2 SGTC_656 4090-1979 5.24 187.0 µM 2.88E-8 4 8.05E-8
3 SGTC_2776 terbinafine 5.19 19.9 µM 3.90E-8 cell wall signaling 29 1.07E-7
4 SGTC_1636 st007707 5.03 68.9 µM 9.57E-8 25 2.47E-7
5 SGTC_3271 9137798 4.58 49.5 µM 1.05E-6 1 2.32E-6
6 SGTC_1930 st074634 4.38 34.3 µM 2.91E-6 RNA pol III & RNase P/MRP 26 6.04E-6
7 SGTC_1629 st005085 4.26 44.9 µM 5.21E-6 RPP1 & pyrimidine depletion 26 1.04E-5
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.06 100.0 µM 1.30E-5 18 2.44E-5
9 SGTC_1194 1488-0194 3.99 225.0 µM 1.81E-5 29 3.33E-5
10 SGTC_893 0958-0369 3.96 48.9 µM 2.05E-5 22 3.75E-5
11 SGTC_580 1123-0028 3.86 41.0 µM 3.26E-5 DNA damage response 40 5.77E-5
12 SGTC_2294 7971431 3.80 200.0 µM 4.08E-5 15 7.14E-5
13 SGTC_1125 tnp00248 3.79 1.3 µM 4.40E-5 34 7.65E-5
14 SGTC_117 lucigenin 3.66 22.1 µM 7.47E-5 redox potentiating 100 1.26E-4
15 SGTC_3114 9122766 3.61 49.5 µM 9.08E-5 24 1.51E-4
16 SGTC_943 3253-1379 3.60 105.0 µM 9.50E-5 35 1.57E-4
17 SGTC_2065 5221596 3.49 34.3 µM 1.49E-4 26 2.40E-4
18 SGTC_2122 5258151 3.44 111.7 µM 1.83E-4 40 2.90E-4
19 SGTC_343 4130-2827 3.40 29.8 µM 2.16E-4 48 3.40E-4
20 SGTC_996 3970-0799 3.38 1.8 µM 2.34E-4 125 3.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.81E-15 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.129 6.25E-14 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.129 6.98E-14 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.114 3.17E-11 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.113 5.48E-11 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.104 1.36E-9 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.104 1.56E-9 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.102 3.59E-9 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.102 3.84E-9 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.100 7.10E-9 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.096 2.36E-8 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.55E-8 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.094 5.27E-8 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.090 2.05E-7 YGL207W SPT16 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
0.089 2.81E-7 YDL092W SRP14 het Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14