YLL061W / MMP1

High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL061W / MMP1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-6.05|P-value:3.47E-11 ID:SGTC_130|Compound:0136-0219|FD-Score:3.18|P-value:3.31E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-2.89|P-value:8.82E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.45|P-value:1.08E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.63|P-value:4.39E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.85|P-value:1.85E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.13|P-value:3.58E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.16|P-value:3.19E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.95|P-value:7.24E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:6.01|P-value:5.61E-11 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.95|P-value:7.17E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.90|P-value:9.56E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.90|P-value:9.67E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.20|P-value:3.08E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.09|P-value:4.75E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-4.36|P-value:1.26E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.18|P-value:3.28E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.25|P-value:2.54E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.09|P-value:4.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.01|P-value:5.70E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.27|P-value:2.36E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-2.93|P-value:7.83E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.55|P-value:7.11E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.16|P-value:3.54E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.71|P-value:3.50E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.91|P-value:8.29E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.91|P-value:6.83E-8 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.95|P-value:7.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.25|P-value:2.50E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.88|P-value:1.57E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.01|P-value:5.62E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.67|P-value:2.74E-7 ID:SGTC_2996|Compound:9066192|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.84|P-value:1.73E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:9.27E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-6.05|P-value:3.47E-11 ID:SGTC_130|Compound:0136-0219|FD-Score:3.18|P-value:3.31E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-2.89|P-value:8.82E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.45|P-value:1.08E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.63|P-value:4.39E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.85|P-value:1.85E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.13|P-value:3.58E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.16|P-value:3.19E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-2.95|P-value:7.24E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:6.01|P-value:5.61E-11 ID:SGTC_1182|Compound:1222-0449|FD-Score:-2.95|P-value:7.17E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.90|P-value:9.56E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.90|P-value:9.67E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.20|P-value:3.08E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.09|P-value:4.75E-4 ID:SGTC_1987|Compound:st072290|FD-Score:-4.36|P-value:1.26E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.18|P-value:3.28E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.25|P-value:2.54E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.09|P-value:4.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.01|P-value:5.70E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.27|P-value:2.36E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-2.93|P-value:7.83E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.55|P-value:7.11E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.16|P-value:3.54E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.71|P-value:3.50E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.98|P-value:7.19E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.91|P-value:8.29E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.91|P-value:6.83E-8 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.95|P-value:7.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.25|P-value:2.50E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.88|P-value:1.57E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.01|P-value:5.62E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.67|P-value:2.74E-7 ID:SGTC_2996|Compound:9066192|FD-Score:3.22|P-value:2.85E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.94|P-value:8.16E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.84|P-value:1.73E-5 ID:SGTC_3235|Compound:9132602|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:9.27E-4

Top fitness defect scores for YLL061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1177 0983-0204 6.01 23.6 µM 5.61E-11 2 9.28E-10
2 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.91 100.0 µM 6.83E-8 13 4.48E-7
3 SGTC_2936 9038235 4.67 15.6 µM 2.74E-7 8 1.50E-6
4 SGTC_3235 9132602 4.43 49.5 µM 1.02E-6 14 4.71E-6
5 SGTC_2249 haloperidol 4.27 116.4 µM 2.36E-6 ergosterol depletion effects on membrane 92 9.82E-6
6 SGTC_2821 7996764 3.88 71.4 µM 1.57E-5 44 5.14E-5
7 SGTC_654 1124-0271 3.85 80.9 µM 1.85E-5 23 5.92E-5
8 SGTC_2420 aureobasidin a 3.71 50.0 nM 3.50E-5 53 1.03E-4
9 SGTC_2408 sulbentine 3.55 18.4 µM 7.11E-5 61 1.92E-4
10 SGTC_595 3909-8003 3.45 73.7 µM 1.08E-4 27 2.76E-4
11 SGTC_1388 3346-4487 3.45 254.0 µM 1.09E-4 40 2.78E-4
12 SGTC_1221 2958-7315 3.45 257.0 µM 1.12E-4 28 2.85E-4
13 SGTC_3148 9097893 3.38 49.5 µM 1.47E-4 59 3.63E-4
14 SGTC_1322 1348-1070 3.28 12.0 µM 2.19E-4 19 5.14E-4
15 SGTC_2794 7785382 3.25 27.3 µM 2.50E-4 67 5.78E-4
16 SGTC_2219 9098279 3.25 200.0 µM 2.54E-4 9 5.86E-4
17 SGTC_2996 9066192 3.22 71.4 µM 2.85E-4 71 6.48E-4
18 SGTC_1525 8-methoxypsoralen 3.20 92.5 µM 3.08E-4 DNA damage response 69 6.92E-4
19 SGTC_2141 5621638 3.18 7.7 µM 3.28E-4 tubulin folding & SWR complex 56 7.33E-4
20 SGTC_130 0136-0219 3.18 337.7 µM 3.31E-4 55 7.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 2.84E-9 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.097 1.94E-8 YDR490C PKH1 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
0.097 1.95E-8 YER164W CHD1 hom Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
0.094 5.65E-8 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.089 2.61E-7 YOL106W_d YOL106W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.38E-7 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.088 3.46E-7 YPL109C_p YPL109C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.087 4.66E-7 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.087 4.82E-7 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.084 1.27E-6 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.083 1.49E-6 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.082 1.79E-6 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.082 1.92E-6 YDL053C PBP4 hom Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.26E-6 YIL077C_p YIL077C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.078 5.44E-6 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication