YLL063C / AYT1

Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL063C / AYT1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.63|P-value:2.42E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-7.55|P-value:4.33E-16 ID:SGTC_419|Compound:nsc-638432|FD-Score:2.84|P-value:9.43E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.01|P-value:4.98E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.16|P-value:4.28E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.16|P-value:2.77E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.03|P-value:4.61E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.88|P-value:1.99E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.78|P-value:3.22E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.40|P-value:1.05E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.04|P-value:6.79E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.89|P-value:5.66E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:4.01|P-value:6.36E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.00|P-value:5.11E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.04|P-value:9.51E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.05|P-value:6.46E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.96|P-value:5.96E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.05|P-value:4.24E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.49|P-value:7.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.21|P-value:3.51E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.68|P-value:3.09E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-4.30|P-value:2.65E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-4.36|P-value:1.94E-6 ID:SGTC_1713|Compound:st033146|FD-Score:2.93|P-value:6.87E-4 ID:SGTC_1733|Compound:st037357|FD-Score:2.83|P-value:9.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.99|P-value:5.44E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.01|P-value:7.56E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.30|P-value:2.49E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.39|P-value:2.45E-9 ID:SGTC_2794|Compound:7785382|FD-Score:3.43|P-value:9.15E-5 ID:SGTC_2797|Compound:7859098|FD-Score:2.91|P-value:7.22E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:3.49E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.17|P-value:4.09E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.05|P-value:4.32E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.08|P-value:3.74E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.18|P-value:4.75E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.16|P-value:2.77E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.42|P-value:1.52E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.56|P-value:6.73E-7 ID:SGTC_3317|Compound:9138495|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-4.21|P-value:4.18E-6 ID:SGTC_3348|Compound:9149464|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.64|P-value:6.04E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.44|P-value:8.83E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.63|P-value:2.42E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-7.55|P-value:4.33E-16 ID:SGTC_419|Compound:nsc-638432|FD-Score:2.84|P-value:9.43E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.01|P-value:4.98E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.16|P-value:4.28E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.16|P-value:2.77E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.03|P-value:4.61E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.88|P-value:1.99E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.78|P-value:3.22E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.40|P-value:1.05E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.04|P-value:6.79E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.89|P-value:5.66E-8 ID:SGTC_990|Compound:3985-0011|FD-Score:4.01|P-value:6.36E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.00|P-value:5.11E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-4.04|P-value:9.51E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.05|P-value:6.46E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.96|P-value:5.96E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.05|P-value:4.24E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.49|P-value:7.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.21|P-value:3.51E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.68|P-value:3.09E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-4.30|P-value:2.65E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-4.36|P-value:1.94E-6 ID:SGTC_1713|Compound:st033146|FD-Score:2.93|P-value:6.87E-4 ID:SGTC_1733|Compound:st037357|FD-Score:2.83|P-value:9.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.99|P-value:5.44E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.01|P-value:7.56E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.30|P-value:2.49E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.39|P-value:2.45E-9 ID:SGTC_2794|Compound:7785382|FD-Score:3.43|P-value:9.15E-5 ID:SGTC_2797|Compound:7859098|FD-Score:2.91|P-value:7.22E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.65|P-value:3.49E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.17|P-value:4.09E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.05|P-value:4.32E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.08|P-value:3.74E-4 ID:SGTC_3070|Compound:9117005|FD-Score:-4.18|P-value:4.75E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.16|P-value:2.77E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.42|P-value:1.52E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.56|P-value:6.73E-7 ID:SGTC_3317|Compound:9138495|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-4.21|P-value:4.18E-6 ID:SGTC_3348|Compound:9149464|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.64|P-value:6.04E-5 ID:SGTC_3354|Compound:9151612|FD-Score:3.44|P-value:8.83E-5

Top fitness defect scores for YLL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.39 100.0 µM 2.45E-9 13 3.45E-8
2 SGTC_968 1309-0633 4.89 340.0 µM 5.66E-8 4 5.16E-7
3 SGTC_68 0986-0284 4.63 82.8 µM 2.42E-7 46 1.81E-6
4 SGTC_990 3985-0011 4.01 41.3 µM 6.36E-6 amide catabolism 18 3.03E-5
5 SGTC_1630 st005209 3.68 31.3 µM 3.09E-5 31 1.19E-4
6 SGTC_2799 7812892 3.65 81.8 µM 3.49E-5 superoxide 39 1.32E-4
7 SGTC_1451 4152-0210 3.49 104.0 µM 7.10E-5 41 2.43E-4
8 SGTC_3354 9151612 3.44 71.4 µM 8.83E-5 29 2.93E-4
9 SGTC_2794 7785382 3.43 27.3 µM 9.15E-5 54 3.02E-4
10 SGTC_959 1222-0044 3.40 107.0 µM 1.05E-4 37 3.42E-4
11 SGTC_2996 9066192 3.35 71.4 µM 1.28E-4 62 4.03E-4
12 SGTC_829 1635-0120 3.16 117.0 µM 2.77E-4 DNA damage response 72 7.85E-4
13 SGTC_3179 9107801 3.16 49.5 µM 2.77E-4 34 7.87E-4
14 SGTC_2999 9069765 3.08 71.4 µM 3.74E-4 amide catabolism 71 0.00102
15 SGTC_1388 3346-4487 3.05 254.0 µM 4.24E-4 62 0.00113
16 SGTC_2811 7967822 3.05 32.5 µM 4.32E-4 55 0.00115
17 SGTC_874 0599-0792 3.03 117.0 µM 4.61E-4 75 0.00122
18 SGTC_735 3076-0345 3.01 636.0 µM 4.98E-4 85 0.00130
19 SGTC_1134 3477-0009 3.00 42.5 µM 5.11E-4 95 0.00133
20 SGTC_2126 5251174 2.99 33.9 µM 5.44E-4 98 0.00141

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.65E-30 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.196 2.48E-30 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.161 6.67E-21 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.147 1.21E-17 YLL056C_p YLL056C_p hom Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
0.126 2.72E-13 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.122 1.15E-12 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.121 1.98E-12 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.116 1.60E-11 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.115 2.25E-11 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.114 3.98E-11 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.107 5.17E-10 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.107 5.55E-10 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.101 4.25E-9 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.099 8.14E-9 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.099 1.04E-8 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication