HIPHOP chemogenomics database

YLR044C / PDC1

Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR044C / PDC1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR044C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_100	0086-0128	18.60	49.6 µM	7.44E-70	copper-dependent oxidative stress	1	2.03E-77
2	SGTC_163	1327-0036	13.10	7.5 µM	1.37E-35		8	2.35E-39
3	SGTC_134	0269-0018	11.90	6.9 µM	8.66E-30		30	6.51E-33
4	SGTC_318	1488-0629	8.45	67.2 µM	5.89E-16	copper-dependent oxidative stress	4	1.50E-17
5	SGTC_2406	ethylparaben	6.96	405.7 µM	2.11E-11		5	1.70E-12
6	SGTC_242	5hr heat shock (37°C) + 5-fluorouracil	6.84	4.6 µM	4.56E-11	heat shock/prefoldin	11	4.00E-12
7	SGTC_2651	1327-0036	6.71	5.0 µM	1.01E-10		52	9.69E-12
8	SGTC_1934	st074720	5.94	32.6 µM	9.16E-9		16	1.43E-9
9	SGTC_66	0109-0187	5.90	42.4 µM	1.14E-8		12	1.82E-9
10	SGTC_567	1080-0542	5.47	68.4 µM	1.08E-7		1	2.20E-8
11	SGTC_2410	aloe-emodin-8-o-glycoside	5.47	46.3 µM	1.08E-7	mitochondrial processes	7	2.20E-8
12	SGTC_1924	st058459	5.19	75.1 µM	4.44E-7		1	1.06E-7
13	SGTC_87	0100-0052	5.06	35.5 µM	8.23E-7		49	2.10E-7
14	SGTC_235	0330-0087	4.66	5.0 mM	5.03E-6	TSC3-RPN4	10	1.56E-6
15	SGTC_3223	9129970	4.65	49.5 µM	5.38E-6		13	1.68E-6
16	SGTC_548	1436-0017	4.55	110.0 µM	8.32E-6	TSC3-RPN4	27	2.73E-6
17	SGTC_79	0052-0007	4.51	94.1 µM	9.65E-6		27	3.22E-6
18	SGTC_2812	7970281	4.49	58.4 µM	1.04E-5		13	3.50E-6
19	SGTC_571	k831-0106	4.49	44.2 µM	1.05E-5		8	3.54E-6
20	SGTC_2782	7736369	4.43	71.4 µM	1.35E-5		26	4.66E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.238	2.19E-44	YFL037W	TUB2	het	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.231	4.83E-42	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.231	5.53E-42	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.218	2.87E-37	YER052C	HOM3	hom	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.199	2.35E-31	YGR193C	PDX1	hom	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.190	1.36E-28	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.188	4.29E-28	YML129C	COX14	hom	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.187	7.41E-28	YIL022W	TIM44	het	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.187	1.15E-27	YJL019W	MPS3	het	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.176	8.29E-25	YHR008C	SOD2	hom	Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.173	7.68E-24	YCR053W	THR4	hom	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.168	1.12E-22	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.167	2.74E-22	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.164	1.50E-21	YJR007W	SUI2	het	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.163	2.66E-21	YPL237W	SUI3	het	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding