YLR064W / PER33

Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR064W / PER33

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:4.18E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.89|P-value:3.01E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.55|P-value:1.30E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.24|P-value:4.04E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.00|P-value:9.58E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.19|P-value:7.47E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:4.19|P-value:7.43E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.52|P-value:1.45E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.76|P-value:5.10E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.06|P-value:8.00E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.07|P-value:1.31E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.70|P-value:6.79E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.09|P-value:1.19E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.10|P-value:6.76E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.61|P-value:9.37E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.01|P-value:1.71E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.72|P-value:6.03E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.23|P-value:4.17E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.34|P-value:3.74E-6 ID:SGTC_1816|Compound:st051957|FD-Score:3.10|P-value:6.86E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.08|P-value:7.22E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.39|P-value:2.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.07|P-value:7.79E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.12|P-value:6.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.31|P-value:3.26E-4 ID:SGTC_2038|Compound:4100038|FD-Score:5.57|P-value:4.34E-9 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-4.73|P-value:5.34E-7 ID:SGTC_2094|Compound:5332512|FD-Score:3.43|P-value:1.93E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.21|P-value:6.93E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.08|P-value:7.23E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.49|P-value:1.60E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.50|P-value:1.69E-6 ID:SGTC_3135|Compound:9127742|FD-Score:-3.27|P-value:3.81E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.34|P-value:2.80E-4 ID:SGTC_3343|Compound:9148379|FD-Score:4.96|P-value:1.51E-7 ID:SGTC_24|Compound:0417-1663|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.23|P-value:4.18E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.89|P-value:3.01E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.07|P-value:7.46E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.55|P-value:1.30E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.24|P-value:4.04E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.00|P-value:9.58E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.19|P-value:7.47E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:4.19|P-value:7.43E-6 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.52|P-value:1.45E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.76|P-value:5.10E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.06|P-value:8.00E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.07|P-value:1.31E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.70|P-value:6.79E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.09|P-value:1.19E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.10|P-value:6.76E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.61|P-value:9.37E-7 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.01|P-value:1.71E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.72|P-value:6.03E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.23|P-value:4.17E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.34|P-value:3.74E-6 ID:SGTC_1816|Compound:st051957|FD-Score:3.10|P-value:6.86E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.08|P-value:7.22E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.39|P-value:2.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.07|P-value:7.79E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.12|P-value:6.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.31|P-value:3.26E-4 ID:SGTC_2038|Compound:4100038|FD-Score:5.57|P-value:4.34E-9 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-4.73|P-value:5.34E-7 ID:SGTC_2094|Compound:5332512|FD-Score:3.43|P-value:1.93E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.45|P-value:1.79E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.21|P-value:6.93E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.08|P-value:7.23E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.44|P-value:1.86E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.27|P-value:3.76E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.49|P-value:1.60E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.51|P-value:1.41E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.50|P-value:1.69E-6 ID:SGTC_3135|Compound:9127742|FD-Score:-3.27|P-value:3.81E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:4.59E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.34|P-value:2.80E-4 ID:SGTC_3343|Compound:9148379|FD-Score:4.96|P-value:1.51E-7

Top fitness defect scores for YLR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2038 4100038 5.57 31.0 µM 4.34E-9 plasma membrane duress 23 1.27E-8
2 SGTC_3343 9148379 4.96 19.0 µM 1.51E-7 2 3.57E-7
3 SGTC_1319 1306-0155 4.61 43.7 µM 9.37E-7 11 1.98E-6
4 SGTC_621 3584-0052 4.55 32.1 µM 1.30E-6 17 2.70E-6
5 SGTC_3013 9080133 4.50 71.4 µM 1.69E-6 9 3.45E-6
6 SGTC_1573 oleylamine 4.34 1.1 µM 3.74E-6 20 7.28E-6
7 SGTC_2225 6654152 4.21 15.4 µM 6.93E-6 13 1.30E-5
8 SGTC_992 3909-8734 4.19 162.0 µM 7.43E-6 12 1.39E-5
9 SGTC_914 3820-6779 4.19 408.0 µM 7.47E-6 18 1.40E-5
10 SGTC_1131 3454-3128 4.09 32.3 µM 1.19E-5 39 2.16E-5
11 SGTC_1078 idebenone 4.07 36.1 µM 1.31E-5 Golgi 40 2.37E-5
12 SGTC_1320 1313-0481 4.01 95.3 µM 1.71E-5 19 3.03E-5
13 SGTC_1055 3448-0672 3.76 86.0 µM 5.10E-5 35 8.50E-5
14 SGTC_1419 3993-2473 3.72 62.6 µM 6.03E-5 22 9.95E-5
15 SGTC_1117 retinoic acid 3.58 1.1 µM 1.07E-4 25 1.71E-4
16 SGTC_1565 sinapyl alcohol 3.52 95.1 µM 1.35E-4 42 2.13E-4
17 SGTC_2936 9038235 3.51 15.6 µM 1.41E-4 38 2.22E-4
18 SGTC_2201 6605497 3.45 169.9 µM 1.79E-4 ergosterol biosynthesis 16 2.77E-4
19 SGTC_2348 9022543 3.44 33.4 µM 1.86E-4 mitochondrial processes 43 2.88E-4
20 SGTC_2094 5332512 3.43 191.7 µM 1.93E-4 43 2.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.00E-14 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.126 3.37E-13 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.088 3.23E-7 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.086 6.62E-7 YLR094C GIS3 hom Protein of unknown function
0.078 6.11E-6 YCR032W BPH1 hom Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
0.077 8.21E-6 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.11E-5 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
0.075 1.33E-5 YNL076W MKS1 hom Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
0.073 2.09E-5 YOR135C_d IRC14_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
0.072 3.00E-5 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.072 3.29E-5 YNL118C DCP2 het Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.070 4.66E-5 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.070 4.65E-5 YAL037W_p YAL037W_p hom Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication
0.070 4.88E-5 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.070 5.55E-5 YDL170W UGA3 hom Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus