YLR068W / FYV7

Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR068W / FYV7

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.45|P-value:5.09E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.85|P-value:6.91E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.89|P-value:6.37E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.41|P-value:3.71E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.47|P-value:2.57E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.43|P-value:3.49E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.11|P-value:2.32E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.72|P-value:1.47E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.38|P-value:4.78E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:5.29|P-value:7.99E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.34|P-value:8.62E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.69|P-value:1.68E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.13|P-value:8.54E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:5.94E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.13|P-value:8.61E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.20|P-value:7.75E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.19|P-value:1.63E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.76|P-value:1.00E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.88|P-value:5.15E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.32|P-value:5.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.14|P-value:1.77E-5 ID:SGTC_1659|Compound:st012954|FD-Score:-3.09|P-value:9.80E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.87|P-value:7.03E-7 ID:SGTC_1781|Compound:st038725|FD-Score:5.12|P-value:1.92E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-3.48|P-value:2.48E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.78|P-value:9.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.21|P-value:7.46E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.37|P-value:4.32E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.18|P-value:1.75E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.65|P-value:1.33E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.80|P-value:7.15E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.74|P-value:1.30E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.67|P-value:1.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.44|P-value:5.34E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.23|P-value:7.12E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.63|P-value:2.22E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:3.34E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-3.34|P-value:4.21E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.66|P-value:1.61E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-6.00|P-value:1.05E-9 ID:SGTC_2842|Compound:9000675|FD-Score:-3.48|P-value:2.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.13|P-value:8.61E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.15|P-value:8.09E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.23|P-value:7.08E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.97|P-value:4.17E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-4.02|P-value:2.94E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.45|P-value:5.09E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.51|P-value:2.19E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.85|P-value:6.91E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.89|P-value:6.37E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.41|P-value:3.71E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.47|P-value:2.57E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.43|P-value:3.49E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.11|P-value:2.32E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.72|P-value:1.47E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:5.38|P-value:4.78E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:5.29|P-value:7.99E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:3.71|P-value:1.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.34|P-value:8.62E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.69|P-value:1.68E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.13|P-value:8.54E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:5.94E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.13|P-value:8.61E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.20|P-value:7.75E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.36|P-value:4.36E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:4.19|P-value:1.63E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.76|P-value:1.00E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.88|P-value:5.15E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.32|P-value:5.13E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.14|P-value:1.77E-5 ID:SGTC_1659|Compound:st012954|FD-Score:-3.09|P-value:9.80E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.87|P-value:7.03E-7 ID:SGTC_1781|Compound:st038725|FD-Score:5.12|P-value:1.92E-7 ID:SGTC_1786|Compound:berberine|FD-Score:-3.48|P-value:2.48E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.78|P-value:9.22E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.21|P-value:7.46E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.37|P-value:4.32E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.50|P-value:4.14E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.18|P-value:1.75E-5 ID:SGTC_2125|Compound:5246583|FD-Score:-3.65|P-value:1.33E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.80|P-value:7.15E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.74|P-value:1.30E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.67|P-value:1.19E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.44|P-value:5.34E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.19|P-value:8.08E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.23|P-value:7.12E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.63|P-value:2.22E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:3.34E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-3.34|P-value:4.21E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-4.66|P-value:1.61E-6 ID:SGTC_2807|Compound:7945238|FD-Score:3.71|P-value:1.21E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-6.00|P-value:1.05E-9 ID:SGTC_2842|Compound:9000675|FD-Score:-3.48|P-value:2.44E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.13|P-value:8.61E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.15|P-value:8.09E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.23|P-value:7.08E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.97|P-value:4.17E-5 ID:SGTC_3268|Compound:9137683|FD-Score:-4.02|P-value:2.94E-5

Top fitness defect scores for YLR068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 6.22 96.7 µM 3.34E-10 calcium & mitochondrial duress 144 2.43E-10
2 SGTC_791 1348-1292 5.38 225.0 µM 4.78E-8 13 3.71E-8
3 SGTC_800 3448-7362 5.29 155.0 µM 7.99E-8 translation 77 6.24E-8
4 SGTC_1781 st038725 5.12 66.3 µM 1.92E-7 NEO1 69 1.52E-7
5 SGTC_335 4077-0256 4.89 27.6 µM 6.37E-7 8 5.11E-7
6 SGTC_1759 st043059 4.87 70.0 µM 7.03E-7 amide catabolism 10 5.65E-7
7 SGTC_2531 methyl deoxycholate 4.74 70.1 µM 1.30E-6 14 1.05E-6
8 SGTC_782 0083-0095 4.72 30.5 µM 1.47E-6 12 1.19E-6
9 SGTC_832 4083-0019 4.69 164.0 µM 1.68E-6 translation 51 1.36E-6
10 SGTC_2661 dactinomycin 4.63 13.0 µM 2.22E-6 redox potentiating 8 1.81E-6
11 SGTC_2003 4023581 4.50 200.0 µM 4.14E-6 cell wall signaling 26 3.41E-6
12 SGTC_118 0083-0097 4.45 135.3 µM 5.09E-6 translation 87 4.20E-6
13 SGTC_2536 dehydroabietamide 4.44 32.0 µM 5.34E-6 23 4.41E-6
14 SGTC_830 4076-0286 4.34 57.8 µM 8.62E-6 translation 45 7.16E-6
15 SGTC_1442 4112-3290 4.19 3.0 µM 1.63E-5 9 1.37E-5
16 SGTC_2041 5107442 4.18 45.3 µM 1.75E-5 RSC complex & mRNA processing 22 1.47E-5
17 SGTC_668 1682-0499 4.11 62.6 µM 2.32E-5 18 1.95E-5
18 SGTC_3059 1327-0034 3.97 3.0 µM 4.17E-5 53 3.54E-5
19 SGTC_1183 1254-0324 3.89 198.0 µM 5.94E-5 22 5.07E-5
20 SGTC_221 trifluoperazine 3.85 10.3 µM 6.91E-5 NEO1-PIK1 216 5.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 3.85E-63 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.230 1.27E-41 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.217 4.33E-37 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.195 3.80E-30 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.193 2.39E-29 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.190 1.72E-28 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.187 7.47E-28 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.184 7.60E-27 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.183 1.45E-26 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.173 7.51E-24 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.172 9.88E-24 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.169 7.17E-23 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.163 2.31E-21 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.159 2.60E-20 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.153 5.59E-19 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58