YLR084C / RAX2

N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR084C / RAX2

Click on Significant Values for Screen Details ID:SGTC_128|Compound:0906-2981|FD-Score:7.25|P-value:2.03E-12 ID:SGTC_131|Compound:0141-0277|FD-Score:5.47|P-value:9.29E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:-9.01|P-value:8.61E-19 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.14|P-value:9.44E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.70|P-value:1.33E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.15|P-value:2.22E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.15|P-value:9.24E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.15|P-value:9.22E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.39|P-value:4.15E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.41|P-value:6.41E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.36|P-value:7.49E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.28|P-value:6.05E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-4.68|P-value:2.19E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.56|P-value:2.25E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.16|P-value:8.99E-4 ID:SGTC_1594|Compound:piperine|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_1691|Compound:st019933|FD-Score:-3.90|P-value:6.22E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.26|P-value:1.42E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.00|P-value:7.59E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-4.42|P-value:6.99E-6 ID:SGTC_2076|Compound:5212012|FD-Score:-3.66|P-value:1.56E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.21|P-value:7.47E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.89|P-value:8.22E-7 ID:SGTC_2324|Compound:6149169|FD-Score:-3.14|P-value:9.46E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.48|P-value:8.95E-8 ID:SGTC_2430|Compound:5571206|FD-Score:-5.81|P-value:6.41E-9 ID:SGTC_2435|Compound:5706476|FD-Score:-4.55|P-value:4.03E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.93|P-value:5.51E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.67|P-value:2.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.65|P-value:1.58E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.54|P-value:2.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.03|P-value:3.73E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.34|P-value:7.95E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.14|P-value:9.43E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.36|P-value:4.58E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.42|P-value:3.63E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:7.25|P-value:2.03E-12 ID:SGTC_131|Compound:0141-0277|FD-Score:5.47|P-value:9.29E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:-9.01|P-value:8.61E-19 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.14|P-value:9.44E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.70|P-value:1.33E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.15|P-value:2.22E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.15|P-value:9.24E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.15|P-value:9.22E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.39|P-value:4.15E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.41|P-value:6.41E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.36|P-value:7.49E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.28|P-value:6.05E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-4.68|P-value:2.19E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:-3.18|P-value:8.26E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.56|P-value:2.25E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.16|P-value:8.99E-4 ID:SGTC_1594|Compound:piperine|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_1691|Compound:st019933|FD-Score:-3.90|P-value:6.22E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.26|P-value:1.42E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.00|P-value:7.59E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-4.42|P-value:6.99E-6 ID:SGTC_2076|Compound:5212012|FD-Score:-3.66|P-value:1.56E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.21|P-value:7.47E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.61|P-value:3.17E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.89|P-value:8.22E-7 ID:SGTC_2324|Compound:6149169|FD-Score:-3.14|P-value:9.46E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.48|P-value:8.95E-8 ID:SGTC_2430|Compound:5571206|FD-Score:-5.81|P-value:6.41E-9 ID:SGTC_2435|Compound:5706476|FD-Score:-4.55|P-value:4.03E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.93|P-value:5.51E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.67|P-value:2.56E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.65|P-value:1.58E-4 ID:SGTC_2814|Compound:7977482|FD-Score:-3.54|P-value:2.38E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.03|P-value:3.73E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.34|P-value:7.95E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.14|P-value:9.43E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.36|P-value:4.58E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.42|P-value:3.63E-4

Top fitness defect scores for YLR084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_128 0906-2981 7.25 13.4 µM 2.03E-12 1 2.04E-13
2 SGTC_2422 chlorphenesin carbamate 5.48 384.2 µM 8.95E-8 7 2.16E-8
3 SGTC_131 0141-0277 5.47 33.9 µM 9.29E-8 11 2.25E-8
4 SGTC_1594 piperine 4.16 70.1 µM 3.97E-5 9 1.60E-5
5 SGTC_1782 st039423 4.00 80.6 µM 7.59E-5 22 3.23E-5
6 SGTC_2694 st077685 3.67 81.9 µM 2.56E-4 endomembrane recycling 39 1.21E-4
7 SGTC_662 k832-1615 3.66 104.0 µM 2.64E-4 26 1.25E-4
8 SGTC_2280 7785178 3.61 200.0 µM 3.17E-4 15 1.53E-4
9 SGTC_972 1319-0219 3.41 195.0 µM 6.41E-4 55 3.28E-4
10 SGTC_1204 4049-0315 3.36 18.3 µM 7.49E-4 55 3.88E-4
11 SGTC_2894 9048625 3.34 32.5 µM 7.95E-4 31 4.14E-4
12 SGTC_1344 1488-0097 3.25 29.1 µM 0.00107 39 5.73E-4
13 SGTC_1052 3253-3998 3.22 198.0 µM 0.00117 47 6.32E-4
14 SGTC_447 ml7 3.21 120.0 µM 0.00122 NEO1-PIK1 58 6.58E-4
15 SGTC_1766 st045414 3.14 44.8 µM 0.00154 RPP1 & pyrimidine depletion 68 8.50E-4
16 SGTC_2427 5545055 3.13 42.8 µM 0.00160 48 8.88E-4
17 SGTC_392 N-ethylmaleimide 3.11 8.3 µM 0.00168 RNA pol III & RNase P/MRP 37 9.35E-4
18 SGTC_1781 st038725 3.03 66.3 µM 0.00212 NEO1 160 0.00121
19 SGTC_2291 7917025 3.02 104.3 µM 0.00223 iron homeostasis 97 0.00127
20 SGTC_880 0833-0487 3.01 87.2 µM 0.00227 mitochondrial processes 50 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 3.08E-53 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.197 9.28E-31 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.179 1.82E-25 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.147 1.46E-17 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.135 3.57E-15 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.128 9.75E-14 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.127 1.93E-13 YKL033W TTI1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
0.125 4.14E-13 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.119 5.22E-12 YHL024W RIM4 hom Putative RNA-binding protein required for the expression of early and middle sporulation genes
0.113 5.21E-11 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.112 9.51E-11 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.110 1.76E-10 YHR189W PTH1 hom One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium
0.104 1.57E-9 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
0.094 4.98E-8 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.094 4.91E-8 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress