YLR093C / NYV1

v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR093C / NYV1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.24|P-value:3.38E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.13|P-value:5.53E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.35|P-value:2.29E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:6.66|P-value:1.72E-12 ID:SGTC_952|Compound:1185-0122|FD-Score:3.67|P-value:6.55E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.02|P-value:7.79E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.70|P-value:5.73E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.64|P-value:7.17E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.38|P-value:2.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.29|P-value:3.75E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-2.98|P-value:9.05E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.86|P-value:2.86E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.84|P-value:2.94E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.15|P-value:5.05E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.04|P-value:7.11E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.21|P-value:4.04E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.65|P-value:5.93E-7 ID:SGTC_2059|Compound:5238311|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.68|P-value:6.24E-5 ID:SGTC_2341|Compound:7987486|FD-Score:5.03|P-value:7.62E-8 ID:SGTC_2344|Compound:7990960|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.09|P-value:9.09E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.83|P-value:3.18E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.93|P-value:1.90E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.41|P-value:1.95E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:7.37E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-4.26|P-value:4.13E-6 ID:SGTC_2877|Compound:9040724|FD-Score:-3.02|P-value:7.64E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.59|P-value:8.91E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.90|P-value:2.40E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.24|P-value:3.38E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.13|P-value:5.53E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.35|P-value:2.29E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.12|P-value:5.63E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:6.66|P-value:1.72E-12 ID:SGTC_952|Compound:1185-0122|FD-Score:3.67|P-value:6.55E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.51|P-value:1.27E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.02|P-value:7.79E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.70|P-value:5.73E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.64|P-value:7.17E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.38|P-value:2.01E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.29|P-value:3.75E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-2.98|P-value:9.05E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.86|P-value:2.86E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.84|P-value:2.94E-5 ID:SGTC_1761|Compound:st044296|FD-Score:3.15|P-value:5.05E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.04|P-value:7.11E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.21|P-value:4.04E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.65|P-value:5.93E-7 ID:SGTC_2059|Compound:5238311|FD-Score:3.15|P-value:5.11E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.68|P-value:6.24E-5 ID:SGTC_2341|Compound:7987486|FD-Score:5.03|P-value:7.62E-8 ID:SGTC_2344|Compound:7990960|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.09|P-value:9.09E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.83|P-value:3.18E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.93|P-value:1.90E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.08|P-value:6.59E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.15|P-value:5.07E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.41|P-value:1.95E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:7.37E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-4.26|P-value:4.13E-6 ID:SGTC_2877|Compound:9040724|FD-Score:-3.02|P-value:7.64E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.98|P-value:9.55E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.59|P-value:8.91E-5

Top fitness defect scores for YLR093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_948 3448-0295 6.66 75.3 µM 1.72E-12 3 1.33E-11
2 SGTC_2341 7987486 5.03 176.7 µM 7.62E-8 6 2.46E-7
3 SGTC_2054 5233173 4.65 129.0 µM 5.93E-7 mitochondrial response to ROS 36 1.62E-6
4 SGTC_1528 arabinosylhypoxanthine 4.29 74.6 µM 3.75E-6 14 8.85E-6
5 SGTC_58 0957-0393 3.90 9.0 µM 2.40E-5 cell wall 378 4.89E-5
6 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.86 61.8 µM 2.86E-5 ergosterol biosynthesis 9 5.74E-5
7 SGTC_2582 agaric acid 3.83 100.0 µM 3.18E-5 redox potentiating 332 6.33E-5
8 SGTC_1206 3978-0017 3.70 132.0 µM 5.73E-5 ERG2 45 1.09E-4
9 SGTC_2089 5281248 3.68 129.7 µM 6.24E-5 superoxide 33 1.18E-4
10 SGTC_952 1185-0122 3.67 232.0 µM 6.55E-5 25 1.23E-4
11 SGTC_1236 0330-0013 3.64 258.0 µM 7.17E-5 21 1.34E-4
12 SGTC_3133 9127736 3.59 49.5 µM 8.91E-5 31 1.63E-4
13 SGTC_470 aa-861 3.54 153.0 µM 1.12E-4 sphingolipid biosynthesis & PDR1 73 2.01E-4
14 SGTC_965 1291-5240 3.51 308.0 µM 1.27E-4 44 2.26E-4
15 SGTC_1781 st038725 3.21 66.3 µM 4.04E-4 NEO1 144 6.58E-4
16 SGTC_1761 st044296 3.15 37.0 µM 5.05E-4 31 8.09E-4
17 SGTC_2803 7707263 3.15 71.4 µM 5.07E-4 60 8.13E-4
18 SGTC_2059 5238311 3.15 157.0 µM 5.11E-4 55 8.19E-4
19 SGTC_463 ikarugamyin 3.13 104.0 µM 5.53E-4 7 8.79E-4
20 SGTC_769 0302-0231 3.12 76.0 µM 5.63E-4 103 8.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.38E-25 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.151 1.31E-18 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.148 7.21E-18 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.147 1.09E-17 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.145 2.81E-17 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.132 1.74E-14 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.130 4.67E-14 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.127 1.36E-13 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.127 1.63E-13 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.126 2.75E-13 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.125 3.47E-13 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.125 4.02E-13 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.123 8.65E-13 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.121 1.84E-12 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.120 3.46E-12 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain