YLR097C / HRT3

Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR097C / HRT3

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:5.50|P-value:2.79E-9 ID:SGTC_199|Compound:4063-0024|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.43|P-value:1.25E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.98|P-value:7.06E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.71|P-value:3.85E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.97|P-value:7.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.85|P-value:2.06E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.69|P-value:7.47E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:9.61E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.92|P-value:8.91E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.09|P-value:4.73E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-4.10|P-value:1.20E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.08|P-value:4.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.43|P-value:1.21E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-3.65|P-value:8.90E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.50|P-value:9.44E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.04|P-value:9.26E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.02|P-value:6.22E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.63|P-value:9.54E-5 ID:SGTC_1797|Compound:st048695|FD-Score:3.64|P-value:5.26E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.30|P-value:2.36E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.91|P-value:9.14E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.22|P-value:2.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.13|P-value:4.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.81|P-value:1.64E-7 ID:SGTC_2814|Compound:7977482|FD-Score:15.80|P-value:6.01E-62 ID:SGTC_2921|Compound:7974240|FD-Score:3.25|P-value:2.59E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.47|P-value:1.00E-6 ID:SGTC_2954|Compound:9074818|FD-Score:4.31|P-value:2.27E-6 ID:SGTC_2973|Compound:9094665|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.10|P-value:7.43E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.50|P-value:2.79E-9 ID:SGTC_199|Compound:4063-0024|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.43|P-value:1.25E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.98|P-value:7.06E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.71|P-value:3.85E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.97|P-value:7.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.85|P-value:2.06E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.69|P-value:7.47E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.89|P-value:9.61E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.92|P-value:8.91E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.09|P-value:4.73E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-4.10|P-value:1.20E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.16|P-value:6.05E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.08|P-value:4.87E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.43|P-value:1.21E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-3.65|P-value:8.90E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.50|P-value:9.44E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.04|P-value:9.26E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.02|P-value:6.22E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.63|P-value:9.54E-5 ID:SGTC_1797|Compound:st048695|FD-Score:3.64|P-value:5.26E-5 ID:SGTC_2084|Compound:5306078|FD-Score:4.30|P-value:2.36E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.91|P-value:9.14E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.22|P-value:2.88E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.13|P-value:4.06E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.81|P-value:1.64E-7 ID:SGTC_2814|Compound:7977482|FD-Score:15.80|P-value:6.01E-62 ID:SGTC_2921|Compound:7974240|FD-Score:3.25|P-value:2.59E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.47|P-value:1.00E-6 ID:SGTC_2954|Compound:9074818|FD-Score:4.31|P-value:2.27E-6 ID:SGTC_2973|Compound:9094665|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.10|P-value:7.43E-4

Top fitness defect scores for YLR097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2814 7977482 15.80 43.0 µM 6.01E-62 1 3.17E-56
2 SGTC_142 0335-0849 5.50 62.7 µM 2.79E-9 ubiquinone biosynthesis & proteasome 72 1.91E-8
3 SGTC_2807 7945238 4.81 52.0 µM 1.64E-7 12 7.58E-7
4 SGTC_2935 9038016 4.47 30.0 µM 1.00E-6 9 3.89E-6
5 SGTC_1625 st003711 4.43 30.1 µM 1.21E-6 calcium & mitochondrial duress 26 4.61E-6
6 SGTC_2954 9074818 4.31 52.7 µM 2.27E-6 29 8.12E-6
7 SGTC_2084 5306078 4.30 60.6 µM 2.36E-6 11 8.42E-6
8 SGTC_1035 k081-0041 3.85 55.2 µM 2.06E-5 Golgi 25 5.94E-5
9 SGTC_988 1497-1057 3.71 103.0 µM 3.85E-5 13 1.05E-4
10 SGTC_1797 st048695 3.64 56.8 µM 5.26E-5 NEO1 77 1.38E-4
11 SGTC_1700 st030840 3.50 7.9 µM 9.44E-5 PDR1 34 2.34E-4
12 SGTC_440 fluspirilene 3.43 35.1 µM 1.25E-4 31 3.03E-4
13 SGTC_914 3820-6779 3.38 408.0 µM 1.50E-4 40 3.56E-4
14 SGTC_2921 7974240 3.25 10.7 µM 2.59E-4 86 5.82E-4
15 SGTC_2430 5571206 3.22 200.0 µM 2.88E-4 90 6.41E-4
16 SGTC_1169 aniline yellow 3.17 25.8 µM 3.49E-4 27 7.62E-4
17 SGTC_199 4063-0024 3.15 41.6 µM 3.73E-4 20 8.09E-4
18 SGTC_2678 equilin 3.13 100.0 µM 4.06E-4 50 8.74E-4
19 SGTC_1413 3910-0535 3.09 34.4 µM 4.73E-4 41 0.00100
20 SGTC_1606 st000094 3.08 49.2 µM 4.87E-4 60S ribosome export 51 0.00103

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 2.03E-67 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.237 3.22E-44 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.230 2.34E-41 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.216 1.03E-36 YMR171C EAR1 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
0.211 5.44E-35 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.204 6.41E-33 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.204 9.82E-33 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.198 5.56E-31 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.197 1.18E-30 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.193 1.20E-29 YKL092C BUD2 hom GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint
0.182 1.98E-26 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.176 8.94E-25 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.175 1.98E-24 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.174 2.72E-24 YKL097C_d YKL097C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.169 8.38E-23 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication