YLR102C / APC9

Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR102C / APC9

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.07|P-value:8.97E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:4.89|P-value:1.32E-7 ID:SGTC_287|Compound:k060-0039|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:1.49E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-5.06|P-value:5.11E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.64|P-value:6.64E-5 ID:SGTC_512|Compound:prima-1|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.01|P-value:1.69E-17 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.27|P-value:2.81E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.05|P-value:6.53E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.74|P-value:4.05E-5 ID:SGTC_1602|Compound:st001878|FD-Score:6.70|P-value:8.82E-13 ID:SGTC_1619|Compound:st003326|FD-Score:3.06|P-value:6.34E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.14|P-value:6.36E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.10|P-value:5.43E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.70|P-value:9.50E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.99|P-value:8.23E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.59|P-value:7.60E-5 ID:SGTC_2011|Compound:4012611|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.03|P-value:7.40E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.95|P-value:9.34E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.36|P-value:1.97E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:6.96|P-value:1.20E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:3.61|P-value:7.00E-5 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.06|P-value:6.23E-4 ID:SGTC_3283|Compound:9109332|FD-Score:2.94|P-value:9.87E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.17|P-value:4.41E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.07|P-value:8.97E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:4.89|P-value:1.32E-7 ID:SGTC_287|Compound:k060-0039|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:1.49E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-5.06|P-value:5.11E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.64|P-value:6.64E-5 ID:SGTC_512|Compound:prima-1|FD-Score:3.03|P-value:7.04E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.01|P-value:1.69E-17 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.27|P-value:2.81E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.05|P-value:6.53E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.74|P-value:4.05E-5 ID:SGTC_1602|Compound:st001878|FD-Score:6.70|P-value:8.82E-13 ID:SGTC_1619|Compound:st003326|FD-Score:3.06|P-value:6.34E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.14|P-value:6.36E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.73|P-value:4.23E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.10|P-value:5.43E-4 ID:SGTC_1765|Compound:st044815|FD-Score:5.70|P-value:9.50E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:2.99|P-value:8.23E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.59|P-value:7.60E-5 ID:SGTC_2011|Compound:4012611|FD-Score:2.97|P-value:8.69E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.03|P-value:7.40E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:2.95|P-value:9.34E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.36|P-value:1.97E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.85|P-value:2.44E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:6.96|P-value:1.20E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:3.61|P-value:7.00E-5 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.06|P-value:6.23E-4 ID:SGTC_3283|Compound:9109332|FD-Score:2.94|P-value:9.87E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_3312|Compound:9133330|FD-Score:-3.17|P-value:4.41E-4

Top fitness defect scores for YLR102C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 8.01 2.6 nM 1.69E-17 cell wall 40 5.77E-16
2 SGTC_2584 androsterone 6.96 48.7 µM 1.20E-13 cell wall 41 1.75E-12
3 SGTC_1602 st001878 6.70 87.6 µM 8.82E-13 2 1.06E-11
4 SGTC_1765 st044815 5.70 90.4 µM 9.50E-10 3 5.88E-9
5 SGTC_17 0960-0276 4.89 49.8 µM 1.32E-7 15 5.11E-7
6 SGTC_304 1310-0298 4.44 97.0 µM 1.49E-6 cell wall 47 4.58E-6
7 SGTC_1621 st003705 4.14 32.4 µM 6.36E-6 calcium & mitochondrial duress 20 1.71E-5
8 SGTC_9 0092-0002 4.07 10.4 µM 8.97E-6 25 2.34E-5
9 SGTC_2325 6158266 3.85 200.0 µM 2.44E-5 25 5.79E-5
10 SGTC_1381 2324-0066 3.74 62.1 µM 4.05E-5 35 9.16E-5
11 SGTC_1677 st019204 3.73 53.9 µM 4.23E-5 24 9.52E-5
12 SGTC_2619 obliquin 3.61 87.9 µM 7.00E-5 cell wall 165 1.51E-4
13 SGTC_2002 4023503 3.59 131.0 µM 7.60E-5 mitochondrial processes 48 1.62E-4
14 SGTC_1363 1636-0063 3.52 10.4 µM 1.05E-4 Golgi 41 2.17E-4
15 SGTC_2105 5350118 3.36 200.0 µM 1.97E-4 48 3.85E-4
16 SGTC_815 1582-0027 3.27 36.9 µM 2.81E-4 66 5.32E-4
17 SGTC_287 k060-0039 3.22 29.6 µM 3.46E-4 24 6.41E-4
18 SGTC_1730 st033808 3.10 45.1 µM 5.43E-4 89 9.66E-4
19 SGTC_3291 9121177 3.07 71.4 µM 6.04E-4 43 0.00106
20 SGTC_2745 rifampicin 3.06 24.3 µM 6.23E-4 9 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 2.24E-121 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.343 5.82E-93 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.328 3.17E-85 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.292 8.40E-67 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.285 6.87E-64 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.281 5.23E-62 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.253 5.50E-50 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.243 2.38E-46 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.235 2.03E-43 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.221 3.11E-38 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.216 1.21E-36 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.215 2.51E-36 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.212 1.99E-35 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.209 1.45E-34 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.208 3.22E-34 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication