YLR107W / REX3

RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR107W / REX3

Click on Significant Values for Screen Details ID:SGTC_428|Compound:3448-4153|FD-Score:4.21|P-value:2.61E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-3.71|P-value:2.77E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.15|P-value:3.38E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.15|P-value:3.03E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.74|P-value:2.41E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.65|P-value:4.03E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.55|P-value:6.27E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.03|P-value:5.28E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.87|P-value:9.67E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:2.11E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.31|P-value:1.74E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.08|P-value:4.02E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.44|P-value:1.00E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.04|P-value:5.20E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.96|P-value:6.44E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.91|P-value:8.32E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.38|P-value:1.32E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.88|P-value:9.36E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.67|P-value:2.21E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.07|P-value:4.66E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.33|P-value:1.61E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.77|P-value:2.06E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.41|P-value:1.15E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.14|P-value:3.48E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.21|P-value:2.61E-6 ID:SGTC_433|Compound:pimozide|FD-Score:-3.71|P-value:2.77E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.15|P-value:3.38E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.15|P-value:3.03E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:-3.07|P-value:4.17E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.07|P-value:4.56E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.74|P-value:2.41E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.65|P-value:4.03E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.55|P-value:6.27E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.03|P-value:5.28E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.87|P-value:9.67E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:2.11E-5 ID:SGTC_1791|Compound:st048313|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.31|P-value:1.74E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.08|P-value:4.02E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.44|P-value:1.00E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.04|P-value:5.20E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-2.96|P-value:6.44E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.91|P-value:8.32E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.38|P-value:1.32E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.88|P-value:9.36E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.67|P-value:2.21E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.07|P-value:4.66E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.33|P-value:1.61E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.77|P-value:2.06E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.41|P-value:1.15E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.14|P-value:3.48E-4

Top fitness defect scores for YLR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2578 7,8-dihydroxyflavone 4.67 64.4 µM 2.21E-7 21 1.50E-6
2 SGTC_428 3448-4153 4.21 16.5 µM 2.61E-6 TSC3-RPN4 26 1.25E-5
3 SGTC_1112 tnp00069 3.65 1.2 µM 4.03E-5 32 1.32E-4
4 SGTC_1261 0712-0010 3.55 12.7 µM 6.27E-5 RNA processing & uracil transport 36 1.93E-4
5 SGTC_2041 5107442 3.44 45.3 µM 1.00E-4 RSC complex & mRNA processing 39 2.88E-4
6 SGTC_3170 9103054 3.41 49.5 µM 1.15E-4 60S ribosome export 33 3.25E-4
7 SGTC_2104 5389443 3.38 200.0 µM 1.32E-4 36 3.65E-4
8 SGTC_2815 7968870 3.33 71.4 µM 1.61E-4 52 4.35E-4
9 SGTC_1795 st049545 3.31 62.3 µM 1.74E-4 TSC3-RPN4 23 4.65E-4
10 SGTC_522 1273-0010 3.15 11.6 µM 3.38E-4 60S ribosome export 49 8.24E-4
11 SGTC_3187 9109394 3.14 49.5 µM 3.48E-4 Golgi 65 8.44E-4
12 SGTC_2074 5212007 3.10 75.4 µM 4.13E-4 36 9.78E-4
13 SGTC_747 3448-8087 3.07 38.7 µM 4.56E-4 67 0.00107
14 SGTC_1791 st048313 3.07 56.1 µM 4.58E-4 37 0.00107
15 SGTC_2687 chenodiol 3.07 100.0 µM 4.66E-4 63 0.00109
16 SGTC_2084 5306078 3.04 60.6 µM 5.20E-4 59 0.00119
17 SGTC_1387 3342-1166 3.03 1.8 µM 5.28E-4 mitochondrial processes 41 0.00121
18 SGTC_2102 5377816 2.91 72.8 µM 8.32E-4 70 0.00179
19 SGTC_2462 5162487 2.88 171.8 µM 9.36E-4 61 0.00199
20 SGTC_1455 4262-0120 2.87 131.0 µM 9.67E-4 plasma membrane duress 85 0.00204

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.98E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.130 5.13E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.122 1.37E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.122 1.67E-12 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.120 3.86E-12 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.119 4.37E-12 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.113 5.52E-11 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.112 7.11E-11 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.22E-10 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.105 9.87E-10 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.105 1.27E-9 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.104 1.54E-9 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.103 2.17E-9 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.103 2.23E-9 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.101 5.44E-9 YHR049W FSH1 hom Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2