YLR112W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR112W / YLR112W

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.24|P-value:1.10E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.83|P-value:6.33E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.02|P-value:2.90E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.77|P-value:8.25E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.19|P-value:9.49E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.81|P-value:7.49E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-2.90|P-value:4.61E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.91|P-value:4.83E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.35|P-value:6.95E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.62|P-value:1.80E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-2.97|P-value:3.58E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.13|P-value:1.88E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.76|P-value:8.71E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.09|P-value:2.26E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.73|P-value:9.51E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:1.59E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.27|P-value:9.96E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.47|P-value:4.01E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.86|P-value:5.72E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.77|P-value:8.22E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.10|P-value:2.17E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.12|P-value:1.85E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.77|P-value:2.73E-8 ID:SGTC_1852|Compound:st056254|FD-Score:3.16|P-value:1.65E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.74|P-value:9.21E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:2.81|P-value:6.94E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-5.53|P-value:1.49E-10 ID:SGTC_2006|Compound:4011487|FD-Score:-3.20|P-value:1.30E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.49|P-value:1.62E-7 ID:SGTC_2008|Compound:4012253|FD-Score:4.59|P-value:9.16E-8 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.63|P-value:1.87E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-2.98|P-value:3.38E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.58|P-value:8.92E-8 ID:SGTC_2436|Compound:5633522|FD-Score:3.35|P-value:7.00E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.23|P-value:1.22E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.96|P-value:3.88E-4 ID:SGTC_2625|Compound:euphol|FD-Score:6.67|P-value:1.59E-14 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.48|P-value:3.76E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.86|P-value:5.42E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.31|P-value:7.99E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.24|P-value:1.18E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.24|P-value:1.10E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.83|P-value:6.33E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.02|P-value:2.90E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.77|P-value:8.25E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.03|P-value:2.83E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.19|P-value:9.49E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.81|P-value:7.49E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:-2.90|P-value:4.61E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.91|P-value:4.83E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.35|P-value:6.95E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.62|P-value:1.80E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:-2.97|P-value:3.58E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.13|P-value:1.88E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.76|P-value:8.71E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.09|P-value:2.26E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:2.73|P-value:9.51E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:1.59E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.27|P-value:9.96E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.47|P-value:4.01E-5 ID:SGTC_1725|Compound:st036284|FD-Score:2.86|P-value:5.72E-4 ID:SGTC_1743|Compound:st037606|FD-Score:2.77|P-value:8.22E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.10|P-value:2.17E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.12|P-value:1.85E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.77|P-value:2.73E-8 ID:SGTC_1852|Compound:st056254|FD-Score:3.16|P-value:1.65E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.74|P-value:9.21E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:2.81|P-value:6.94E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-5.53|P-value:1.49E-10 ID:SGTC_2006|Compound:4011487|FD-Score:-3.20|P-value:1.30E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.49|P-value:1.62E-7 ID:SGTC_2008|Compound:4012253|FD-Score:4.59|P-value:9.16E-8 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.63|P-value:1.87E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-2.98|P-value:3.38E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.58|P-value:8.92E-8 ID:SGTC_2436|Compound:5633522|FD-Score:3.35|P-value:7.00E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.23|P-value:1.22E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.96|P-value:3.88E-4 ID:SGTC_2625|Compound:euphol|FD-Score:6.67|P-value:1.59E-14 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.48|P-value:3.76E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.86|P-value:5.42E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.31|P-value:7.99E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.24|P-value:1.18E-4

Top fitness defect scores for YLR112W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 6.67 100.0 µM 1.59E-14 2 1.25E-11
2 SGTC_2008 4012253 4.59 172.0 µM 9.16E-8 11 2.24E-6
3 SGTC_2007 4011539 4.49 71.8 µM 1.62E-7 cell wall signaling 41 3.49E-6
4 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.19 8.0 µM 9.49E-7 23 1.39E-5
5 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.81 150.0 µM 7.49E-6 Golgi 43 6.98E-5
6 SGTC_2130 NSC 7 3.63 2.5 µM 1.87E-5 copper-dependent oxidative stress 40 1.43E-4
7 SGTC_2633 5,7-dihydroxyisoflavone 3.48 100.0 µM 3.76E-5 44 2.47E-4
8 SGTC_1713 st033146 3.47 12.8 µM 4.01E-5 42 2.60E-4
9 SGTC_1034 k072-0165 3.35 12.7 µM 6.95E-5 Golgi 43 4.00E-4
10 SGTC_2436 5633522 3.35 8.1 µM 7.00E-5 33 4.02E-4
11 SGTC_1630 st005209 3.27 31.3 µM 9.96E-5 56 5.30E-4
12 SGTC_3075 9116269 3.24 49.5 µM 1.18E-4 43 6.04E-4
13 SGTC_2438 5259590 3.23 200.0 µM 1.22E-4 35 6.20E-4
14 SGTC_1852 st056254 3.16 31.4 µM 1.65E-4 36 7.89E-4
15 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.15 70.1 µM 1.74E-4 72 8.21E-4
16 SGTC_1134 3477-0009 3.13 42.5 µM 1.88E-4 84 8.74E-4
17 SGTC_1831 st055328 3.10 12.0 µM 2.17E-4 heme biosynthesis & mitochondrial translocase 59 9.77E-4
18 SGTC_1245 0418-0076 3.09 17.2 µM 2.26E-4 ERG2 67 0.00101
19 SGTC_388 3',4'-dichloroisocoumarin 3.03 16.7 µM 2.83E-4 43 0.00120
20 SGTC_2614 arthonioic acid 2.96 13.4 µM 3.88E-4 63 0.00154

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.63E-27 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.171 2.65E-23 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.147 1.24E-17 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 1.08E-12 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.120 4.23E-12 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.115 2.63E-11 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.113 5.01E-11 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.113 4.80E-11 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.112 7.98E-11 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.108 3.20E-10 YPR048W TAH18 het Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance
0.103 2.53E-9 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.100 6.09E-9 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.099 8.31E-9 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.099 9.85E-9 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.098 1.49E-8 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication