YLR122C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR122C / YLR122C

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.37|P-value:2.79E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.54|P-value:1.45E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.31|P-value:7.20E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.16|P-value:7.43E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.87|P-value:4.45E-7 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.36|P-value:3.64E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.26|P-value:5.31E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:8.26|P-value:3.26E-17 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.63|P-value:1.02E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.93|P-value:3.88E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.26|P-value:5.21E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.21|P-value:6.28E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.66|P-value:1.34E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.16|P-value:7.44E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.45|P-value:2.02E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.78|P-value:5.55E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.86|P-value:3.90E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.99|P-value:2.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.27|P-value:8.64E-6 ID:SGTC_1861|Compound:st057647|FD-Score:-4.36|P-value:4.18E-6 ID:SGTC_1914|Compound:st062367|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.58|P-value:1.60E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.63|P-value:1.11E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-3.82|P-value:4.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:-3.98|P-value:2.31E-5 ID:SGTC_2015|Compound:5119600|FD-Score:6.51|P-value:2.37E-11 ID:SGTC_2317|Compound:5986382|FD-Score:4.09|P-value:1.90E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.13|P-value:6.74E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.35|P-value:2.93E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.18|P-value:9.37E-6 ID:SGTC_2889|Compound:9059656|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.17|P-value:5.70E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.20|P-value:5.15E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.51|P-value:2.04E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.37|P-value:2.79E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.54|P-value:1.45E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.58|P-value:1.56E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.31|P-value:7.20E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.16|P-value:7.43E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.87|P-value:4.45E-7 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.36|P-value:3.64E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.15|P-value:7.86E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.26|P-value:5.31E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:8.26|P-value:3.26E-17 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.63|P-value:1.02E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.93|P-value:3.88E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.26|P-value:5.21E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.21|P-value:6.28E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.66|P-value:1.34E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.16|P-value:7.44E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.45|P-value:2.02E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.78|P-value:5.55E-5 ID:SGTC_1846|Compound:st056244|FD-Score:-3.86|P-value:3.90E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-3.99|P-value:2.18E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.27|P-value:8.64E-6 ID:SGTC_1861|Compound:st057647|FD-Score:-4.36|P-value:4.18E-6 ID:SGTC_1914|Compound:st062367|FD-Score:4.06|P-value:2.22E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.58|P-value:1.60E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.63|P-value:1.11E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-3.82|P-value:4.68E-5 ID:SGTC_2014|Compound:4013930|FD-Score:-3.98|P-value:2.31E-5 ID:SGTC_2015|Compound:5119600|FD-Score:6.51|P-value:2.37E-11 ID:SGTC_2317|Compound:5986382|FD-Score:4.09|P-value:1.90E-5 ID:SGTC_2340|Compound:7987427|FD-Score:-3.13|P-value:6.74E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.47|P-value:2.39E-4 ID:SGTC_2474|Compound:5321570|FD-Score:-3.35|P-value:2.93E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.18|P-value:9.37E-6 ID:SGTC_2889|Compound:9059656|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.60|P-value:1.47E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.17|P-value:5.70E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.20|P-value:5.15E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.51|P-value:2.04E-4

Top fitness defect scores for YLR122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1015 4130-4525 8.26 82.0 µM 3.26E-17 60S ribosome export 1 7.09E-17
2 SGTC_2015 5119600 6.51 184.0 µM 2.37E-11 8 3.67E-11
3 SGTC_364 0083-0097 4.87 67.7 µM 4.45E-7 13 5.47E-7
4 SGTC_1182 1222-0449 4.66 220.0 µM 1.34E-6 8 1.60E-6
5 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.31 8.9 µM 7.20E-6 heat shock/prefoldin 33 8.34E-6
6 SGTC_1859 st055998 4.27 20.0 µM 8.64E-6 17 9.96E-6
7 SGTC_2317 5986382 4.09 200.0 µM 1.90E-5 12 2.16E-5
8 SGTC_1914 st062367 4.06 72.6 µM 2.22E-5 18 2.50E-5
9 SGTC_1024 4507-0395 3.93 26.0 µM 3.88E-5 TSC3-RPN4 28 4.33E-5
10 SGTC_2945 9067681 3.60 61.8 µM 1.47E-4 21 1.60E-4
11 SGTC_148 3253-0744 3.58 288.0 µM 1.56E-4 26 1.69E-4
12 SGTC_2001 4023502 3.58 57.7 µM 1.60E-4 mitochondrial processes 29 1.74E-4
13 SGTC_1149 3909-7961 3.56 23.3 µM 1.70E-4 34 1.84E-4
14 SGTC_3145 9085516 3.51 49.5 µM 2.04E-4 fatty acid desaturase (OLE1) 43 2.20E-4
15 SGTC_2429 5902844 3.47 64.4 µM 2.39E-4 48 2.57E-4
16 SGTC_2889 9059656 3.45 52.0 µM 2.58E-4 18 2.77E-4
17 SGTC_494 Boc-Gly-Val-Val-CHO 3.36 140.0 µM 3.64E-4 18 3.88E-4
18 SGTC_1030 k029-0042 3.26 36.7 µM 5.21E-4 TSC3-RPN4 57 5.52E-4
19 SGTC_776 4476-4378 3.26 112.0 µM 5.31E-4 ERG2 44 5.62E-4
20 SGTC_1172 0370-0043 3.21 85.0 µM 6.28E-4 48 6.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 7.52E-9 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.093 6.23E-8 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.089 2.60E-7 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.085 8.08E-7 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.081 3.01E-6 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.07E-6 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.078 5.65E-6 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.078 6.25E-6 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.077 7.84E-6 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.077 8.65E-6 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.073 2.40E-5 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.073 2.46E-5 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.072 2.67E-5 YGL069C_d YGL069C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
0.072 2.84E-5 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.072 2.98E-5 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate