YLR123C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR123C / YLR123C

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.90|P-value:1.81E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.67|P-value:7.80E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.25|P-value:2.82E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.71|P-value:4.29E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.01|P-value:6.77E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.65|P-value:5.46E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.02|P-value:9.49E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.08|P-value:7.67E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:2.93|P-value:9.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.37|P-value:1.90E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.92|P-value:9.53E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.16|P-value:8.78E-6 ID:SGTC_1519|Compound:esterone|FD-Score:-4.11|P-value:1.10E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.28|P-value:2.53E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.11|P-value:6.93E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.02|P-value:6.59E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.04|P-value:8.96E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.43|P-value:2.05E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.95|P-value:1.46E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.59|P-value:6.94E-5 ID:SGTC_2457|Compound:5731572|FD-Score:2.93|P-value:9.12E-4 ID:SGTC_2487|Compound:5918373|FD-Score:8.34|P-value:8.88E-19 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.15|P-value:5.76E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.94|P-value:1.55E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.88|P-value:1.99E-5 ID:SGTC_2821|Compound:7996764|FD-Score:5.82|P-value:4.26E-10 ID:SGTC_2881|Compound:9058953|FD-Score:-5.61|P-value:3.22E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.65|P-value:8.41E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.10|P-value:7.34E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.42|P-value:1.43E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_3332|Compound:9141069|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.00|P-value:7.19E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.33|P-value:2.01E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.90|P-value:1.81E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.67|P-value:7.80E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.25|P-value:2.82E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.71|P-value:4.29E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.01|P-value:6.77E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.65|P-value:5.46E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.02|P-value:9.49E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.08|P-value:7.67E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:2.93|P-value:9.23E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.26|P-value:2.65E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.37|P-value:1.90E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.92|P-value:9.53E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.30|P-value:2.26E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.16|P-value:8.78E-6 ID:SGTC_1519|Compound:esterone|FD-Score:-4.11|P-value:1.10E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.98|P-value:7.60E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.28|P-value:2.53E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.09|P-value:5.11E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.11|P-value:6.93E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.02|P-value:6.59E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.04|P-value:8.96E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.43|P-value:2.05E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.26|P-value:2.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.95|P-value:1.46E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.59|P-value:6.94E-5 ID:SGTC_2457|Compound:5731572|FD-Score:2.93|P-value:9.12E-4 ID:SGTC_2487|Compound:5918373|FD-Score:8.34|P-value:8.88E-19 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.15|P-value:5.76E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.94|P-value:1.55E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.88|P-value:1.99E-5 ID:SGTC_2821|Compound:7996764|FD-Score:5.82|P-value:4.26E-10 ID:SGTC_2881|Compound:9058953|FD-Score:-5.61|P-value:3.22E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.65|P-value:8.41E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.10|P-value:7.34E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.42|P-value:1.43E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_3332|Compound:9141069|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.00|P-value:7.19E-4

Top fitness defect scores for YLR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2487 5918373 8.34 44.0 µM 8.88E-19 3 3.69E-17
2 SGTC_2821 7996764 5.82 71.4 µM 4.26E-10 7 2.96E-9
3 SGTC_1083 didemethylchlorpromazine sulfoxide 4.37 707.4 nM 1.90E-6 redox potentiating 57 6.18E-6
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.15 3.7 µM 5.76E-6 75 1.70E-5
5 SGTC_2260 7964312 3.95 200.0 µM 1.46E-5 13 3.93E-5
6 SGTC_2566 crystal violet carbinol 3.94 226.0 nM 1.55E-5 38 4.16E-5
7 SGTC_319 1348-1596 3.90 45.5 µM 1.81E-5 RSC & ERG11 19 4.80E-5
8 SGTC_2819 7996655 3.88 46.4 µM 1.99E-5 23 5.23E-5
9 SGTC_357 1325-0123 3.71 420.0 µM 4.29E-5 11 1.05E-4
10 SGTC_446 go6976 3.65 132.0 µM 5.46E-5 17 1.31E-4
11 SGTC_2261 9010538 3.59 184.7 µM 6.94E-5 27 1.63E-4
12 SGTC_533 1222-0222 3.47 6.7 µM 1.15E-4 PDR1 47 2.57E-4
13 SGTC_2991 9074669 3.42 71.4 µM 1.43E-4 azole & statin 91 3.13E-4
14 SGTC_40 0327-0103 3.33 19.8 µM 2.01E-4 50 4.27E-4
15 SGTC_1432 4049-0298 3.30 68.4 µM 2.26E-4 22 4.75E-4
16 SGTC_1713 st033146 3.28 12.8 µM 2.53E-4 54 5.26E-4
17 SGTC_996 3970-0799 3.26 1.8 µM 2.65E-4 134 5.50E-4
18 SGTC_2259 7964009 3.26 200.0 µM 2.73E-4 superoxide 58 5.65E-4
19 SGTC_356 1634-0012 3.25 32.5 µM 2.82E-4 53 5.80E-4
20 SGTC_2624 nerol 3.18 100.0 µM 3.64E-4 30 7.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.26E-26 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.162 3.46E-21 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.132 1.78E-14 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.120 3.33E-12 YMR304C-A_d YMR304C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
0.114 4.30E-11 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.113 5.37E-11 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.110 1.81E-10 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.110 1.92E-10 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.108 3.95E-10 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.107 4.40E-10 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.91E-10 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.105 1.16E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.103 2.23E-9 YLR140W_d YLR140W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
0.103 2.34E-9 YDR380W ARO10 hom Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
0.102 2.78E-9 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs