YLR124W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR124W / YLR124W

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.27|P-value:6.72E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.79|P-value:9.63E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.21|P-value:8.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.43|P-value:6.39E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.39|P-value:4.25E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.33|P-value:5.43E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.24|P-value:7.44E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.76|P-value:1.07E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.12|P-value:2.49E-5 ID:SGTC_2056|Compound:5235370|FD-Score:4.05|P-value:3.30E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.38|P-value:4.54E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.20|P-value:8.66E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.28|P-value:6.50E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.98|P-value:4.52E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:3.75E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.65|P-value:2.56E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.47|P-value:3.30E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.14|P-value:9.95E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.83|P-value:1.00E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-4.86|P-value:9.21E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.25|P-value:6.76E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.19|P-value:8.44E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.27|P-value:6.72E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.22|P-value:7.44E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.79|P-value:9.63E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.21|P-value:8.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.43|P-value:6.39E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.39|P-value:4.25E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-3.33|P-value:5.43E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.59|P-value:2.06E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.17|P-value:9.47E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.24|P-value:7.44E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.76|P-value:1.07E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.12|P-value:2.49E-5 ID:SGTC_2056|Compound:5235370|FD-Score:4.05|P-value:3.30E-5 ID:SGTC_2287|Compound:7945887|FD-Score:-3.38|P-value:4.54E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-3.20|P-value:8.66E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.28|P-value:6.50E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.98|P-value:4.52E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.42|P-value:3.75E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.65|P-value:2.56E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-3.47|P-value:3.30E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.14|P-value:9.95E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.83|P-value:1.00E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-4.86|P-value:9.21E-7 ID:SGTC_3153|Compound:9100258|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.25|P-value:6.76E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.19|P-value:8.44E-4

Top fitness defect scores for YLR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2716 st080858 4.83 38.6 µM 1.00E-6 60S ribosome export 8 6.86E-7
2 SGTC_796 1234-0020 4.43 70.7 µM 6.39E-6 SWF1 & branched chain AA biosynthesis 17 4.65E-6
3 SGTC_2055 5235184 4.12 200.0 µM 2.49E-5 ERG2 24 1.90E-5
4 SGTC_2056 5235370 4.05 200.0 µM 3.30E-5 37 2.53E-5
5 SGTC_2451 5856223 3.98 45.7 µM 4.52E-5 23 3.51E-5
6 SGTC_229 benomyl 3.79 22.9 µM 9.63E-5 tubulin folding & SWR complex 33 7.64E-5
7 SGTC_1999 st074831 3.76 12.5 µM 1.07E-4 plasma membrane duress 38 8.52E-5
8 SGTC_3153 9100258 3.73 49.5 µM 1.18E-4 27 9.42E-5
9 SGTC_2836 9010338 3.67 19.5 µM 1.49E-4 RPP1 & pyrimidine depletion 39 1.20E-4
10 SGTC_1504 k297-0033 3.59 30.0 µM 2.06E-4 21 1.67E-4
11 SGTC_1429 4049-0205 3.54 9.5 µM 2.47E-4 20 2.02E-4
12 SGTC_3202 9113761 3.50 49.5 µM 2.82E-4 63 2.32E-4
13 SGTC_2601 securinine 3.42 100.0 µM 3.75E-4 45 3.11E-4
14 SGTC_2588 indole-3-carbinol 3.40 100.0 µM 4.11E-4 71 3.42E-4
15 SGTC_3117 9124945 3.39 49.5 µM 4.24E-4 13 3.52E-4
16 SGTC_1004 4084-0029 3.39 199.0 µM 4.25E-4 37 3.54E-4
17 SGTC_227 fluconazole 3.29 33.5 µM 5.91E-4 azole & statin 119 4.96E-4
18 SGTC_3204 9114183 3.25 49.5 µM 6.76E-4 61 5.71E-4
19 SGTC_184 1494-0393 3.22 24.7 µM 7.44E-4 99 6.30E-4
20 SGTC_3283 9109332 3.19 35.8 µM 8.44E-4 DNA intercalators 30 7.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.20E-10 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.105 1.05E-9 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.102 2.83E-9 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.100 7.47E-9 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.097 2.04E-8 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.090 1.65E-7 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.089 2.77E-7 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.087 4.36E-7 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.085 7.59E-7 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.085 8.30E-7 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.081 2.42E-6 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.080 3.96E-6 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.079 4.90E-6 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.078 5.90E-6 YHL037C_d YHL037C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.61E-6 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting