YLR125W_p

Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR125W / YLR125W

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.63|P-value:1.48E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.19|P-value:7.49E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:5.54|P-value:1.86E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.02|P-value:3.14E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.12|P-value:9.42E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:6.12|P-value:6.10E-10 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.55|P-value:2.46E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.94|P-value:4.48E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.41|P-value:3.40E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.31|P-value:9.08E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.16|P-value:8.07E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.12|P-value:9.46E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-4.39|P-value:7.99E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.46|P-value:2.86E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.21|P-value:6.85E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.34|P-value:5.24E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.15|P-value:8.46E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.07|P-value:2.60E-5 ID:SGTC_1900|Compound:st060200|FD-Score:5.26|P-value:8.50E-8 ID:SGTC_1944|Compound:st076371|FD-Score:3.33|P-value:4.61E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.42|P-value:3.23E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.10|P-value:9.90E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.18|P-value:1.62E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-7.56|P-value:4.85E-14 ID:SGTC_2020|Compound:4017018|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_2049|Compound:5262831|FD-Score:5.21|P-value:1.16E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.08|P-value:2.46E-5 ID:SGTC_2054|Compound:5233173|FD-Score:5.62|P-value:1.21E-8 ID:SGTC_2112|Compound:5488546|FD-Score:-3.79|P-value:9.79E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.21|P-value:8.31E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.11|P-value:9.55E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.22|P-value:7.97E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.19|P-value:8.88E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.76|P-value:9.10E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.49|P-value:3.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.52|P-value:2.78E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.94|P-value:4.40E-5 ID:SGTC_2447|Compound:5741742|FD-Score:4.84|P-value:7.40E-7 ID:SGTC_2450|Compound:5739737|FD-Score:5.96|P-value:1.66E-9 ID:SGTC_2453|Compound:5731132|FD-Score:6.56|P-value:3.81E-11 ID:SGTC_2478|Compound:5763493|FD-Score:-3.40|P-value:4.21E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.56|P-value:2.90E-6 ID:SGTC_2673|Compound:kobusone|FD-Score:3.52|P-value:2.29E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.57|P-value:1.86E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.79|P-value:1.26E-6 ID:SGTC_2940|Compound:9060638|FD-Score:-4.19|P-value:1.89E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.24|P-value:6.12E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.75|P-value:9.62E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.84|P-value:8.02E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.37|P-value:6.85E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:3.63|P-value:1.48E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.19|P-value:7.49E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:5.54|P-value:1.86E-8 ID:SGTC_749|Compound:1000-0129|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.02|P-value:3.14E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.12|P-value:9.42E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:6.12|P-value:6.10E-10 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.55|P-value:2.46E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.94|P-value:4.48E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.41|P-value:3.40E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.31|P-value:9.08E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.16|P-value:8.07E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.12|P-value:9.46E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-4.39|P-value:7.99E-6 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.46|P-value:2.86E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.21|P-value:6.85E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.34|P-value:5.24E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.15|P-value:8.46E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.07|P-value:2.60E-5 ID:SGTC_1900|Compound:st060200|FD-Score:5.26|P-value:8.50E-8 ID:SGTC_1944|Compound:st076371|FD-Score:3.33|P-value:4.61E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.42|P-value:3.23E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.10|P-value:9.90E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.18|P-value:1.62E-5 ID:SGTC_2017|Compound:5132927|FD-Score:-7.56|P-value:4.85E-14 ID:SGTC_2020|Compound:4017018|FD-Score:4.04|P-value:2.90E-5 ID:SGTC_2049|Compound:5262831|FD-Score:5.21|P-value:1.16E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.08|P-value:2.46E-5 ID:SGTC_2054|Compound:5233173|FD-Score:5.62|P-value:1.21E-8 ID:SGTC_2112|Compound:5488546|FD-Score:-3.79|P-value:9.79E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.21|P-value:8.31E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.11|P-value:9.55E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.22|P-value:7.97E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.19|P-value:8.88E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.76|P-value:9.10E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.49|P-value:3.08E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.52|P-value:2.78E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.94|P-value:4.40E-5 ID:SGTC_2447|Compound:5741742|FD-Score:4.84|P-value:7.40E-7 ID:SGTC_2450|Compound:5739737|FD-Score:5.96|P-value:1.66E-9 ID:SGTC_2453|Compound:5731132|FD-Score:6.56|P-value:3.81E-11 ID:SGTC_2478|Compound:5763493|FD-Score:-3.40|P-value:4.21E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.41|P-value:3.35E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.56|P-value:2.90E-6 ID:SGTC_2673|Compound:kobusone|FD-Score:3.52|P-value:2.29E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.57|P-value:1.86E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.79|P-value:1.26E-6 ID:SGTC_2940|Compound:9060638|FD-Score:-4.19|P-value:1.89E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.24|P-value:6.12E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.75|P-value:9.62E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.84|P-value:8.02E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.37|P-value:6.85E-6

Top fitness defect scores for YLR125W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2453 5731132 6.56 22.2 µM 3.81E-11 1 2.76E-11
2 SGTC_819 1013-0258 6.12 27.7 µM 6.10E-10 17 4.65E-10
3 SGTC_2450 5739737 5.96 12.9 µM 1.66E-9 3 1.29E-9
4 SGTC_2054 5233173 5.62 129.0 µM 1.21E-8 mitochondrial response to ROS 17 9.74E-9
5 SGTC_316 k060-0003 5.54 58.6 µM 1.86E-8 2 1.50E-8
6 SGTC_1456 k015-0012 5.46 13.0 µM 2.86E-8 5 2.33E-8
7 SGTC_1900 st060200 5.26 72.8 µM 8.50E-8 6 7.08E-8
8 SGTC_2049 5262831 5.21 67.2 µM 1.16E-7 8 9.68E-8
9 SGTC_2447 5741742 4.84 33.8 µM 7.40E-7 9 6.39E-7
10 SGTC_2633 5,7-dihydroxyisoflavone 4.56 100.0 µM 2.90E-6 21 2.57E-6
11 SGTC_3192 9110362 4.37 49.5 µM 6.85E-6 mitochondrial processes 6 6.14E-6
12 SGTC_1273 0849-0096 4.31 14.1 µM 9.08E-6 RPP1 & pyrimidine depletion 11 8.18E-6
13 SGTC_2015 5119600 4.18 184.0 µM 1.62E-5 24 1.48E-5
14 SGTC_2052 5265182 4.08 7.1 µM 2.46E-5 27 2.25E-5
15 SGTC_1847 st056231 4.07 15.0 µM 2.60E-5 34 2.38E-5
16 SGTC_2020 4017018 4.04 200.0 µM 2.90E-5 17 2.66E-5
17 SGTC_785 1270-0111 4.02 65.3 µM 3.14E-5 22 2.89E-5
18 SGTC_2412 st077135 3.94 33.4 µM 4.40E-5 24 4.06E-5
19 SGTC_994 3910-0338 3.94 138.0 µM 4.48E-5 calcium & mitochondrial duress 47 4.15E-5
20 SGTC_2389 9091542 3.76 195.5 µM 9.10E-5 iron homeostasis 39 8.51E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.64E-7 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.087 4.05E-7 YER156C_p YER156C_p hom Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
0.087 4.92E-7 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.079 4.16E-6 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.076 9.45E-6 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.076 9.75E-6 YER036C ARB1 het ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
0.076 1.14E-5 YJL030W MAD2 hom Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
0.072 3.12E-5 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.069 5.69E-5 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.069 5.97E-5 YBR005W RCR1 hom Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication
0.068 7.31E-5 YER175W-A_p YER175W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.067 1.09E-4 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.066 1.16E-4 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.065 1.48E-4 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.064 1.99E-4 YMR153C-A_d YMR153C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53