YLR173W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR173W / YLR173W

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.31|P-value:4.08E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:4.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.64|P-value:1.32E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.46|P-value:2.40E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:7.50|P-value:2.61E-14 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:5.02E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:4.20|P-value:1.27E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.10|P-value:9.39E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.77|P-value:7.61E-7 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:5.07|P-value:1.85E-7 ID:SGTC_1696|Compound:st025591|FD-Score:3.52|P-value:2.12E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.90|P-value:4.18E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-4.62|P-value:1.60E-6 ID:SGTC_1895|Compound:st058434|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.81|P-value:7.17E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-5.26|P-value:5.65E-8 ID:SGTC_1919|Compound:st067113|FD-Score:4.69|P-value:1.26E-6 ID:SGTC_1938|Compound:st074717|FD-Score:-3.60|P-value:1.38E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.48|P-value:2.19E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.29|P-value:4.85E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.28|P-value:8.89E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.64|P-value:1.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.18|P-value:1.25E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.72|P-value:9.60E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.70|P-value:9.26E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-4.44|P-value:3.71E-6 ID:SGTC_2932|Compound:9016711|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.45|P-value:2.74E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.13|P-value:8.61E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.95|P-value:3.73E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.31|P-value:4.08E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:4.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.64|P-value:1.32E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.46|P-value:2.40E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:7.50|P-value:2.61E-14 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:5.02E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.99|P-value:3.18E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:4.20|P-value:1.27E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.10|P-value:9.39E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.77|P-value:7.61E-7 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.19|P-value:7.11E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.10|P-value:8.77E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:5.07|P-value:1.85E-7 ID:SGTC_1696|Compound:st025591|FD-Score:3.52|P-value:2.12E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.90|P-value:4.18E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-4.62|P-value:1.60E-6 ID:SGTC_1895|Compound:st058434|FD-Score:3.58|P-value:1.66E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.81|P-value:7.17E-7 ID:SGTC_1916|Compound:st067606|FD-Score:-5.26|P-value:5.65E-8 ID:SGTC_1919|Compound:st067113|FD-Score:4.69|P-value:1.26E-6 ID:SGTC_1938|Compound:st074717|FD-Score:-3.60|P-value:1.38E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.48|P-value:2.19E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.29|P-value:4.85E-4 ID:SGTC_2355|Compound:9061122|FD-Score:4.28|P-value:8.89E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.31|P-value:4.54E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.64|P-value:1.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.18|P-value:1.25E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.72|P-value:9.60E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.70|P-value:9.26E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-4.44|P-value:3.71E-6 ID:SGTC_2932|Compound:9016711|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.45|P-value:2.74E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.13|P-value:8.61E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.95|P-value:3.73E-5

Top fitness defect scores for YLR173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_300 r073-0011 7.50 5.0 µM 2.61E-14 2 3.29E-14
2 SGTC_1503 4585-0012 5.07 61.3 µM 1.85E-7 3 2.01E-7
3 SGTC_1911 st060208 4.81 74.3 µM 7.17E-7 16 7.70E-7
4 SGTC_1919 st067113 4.69 52.3 µM 1.26E-6 TSC3-RPN4 18 1.34E-6
5 SGTC_2355 9061122 4.28 103.1 µM 8.89E-6 9 9.34E-6
6 SGTC_764 1951-2361 4.20 146.0 µM 1.27E-5 28 1.33E-5
7 SGTC_309 k408-0051 3.99 1.5 µM 3.18E-5 44 3.30E-5
8 SGTC_2989 9073649 3.95 71.4 µM 3.73E-5 39 3.88E-5
9 SGTC_2635 hydroquinidine 3.72 100.0 µM 9.60E-5 28 9.91E-5
10 SGTC_1943 st076331 3.68 65.2 µM 1.12E-4 21 1.16E-4
11 SGTC_101 0490-5701 3.64 117.5 µM 1.32E-4 18 1.35E-4
12 SGTC_2556 citropten 3.64 84.6 µM 1.34E-4 34 1.38E-4
13 SGTC_1133 3473-0247 3.63 50.0 µM 1.40E-4 RSC complex & mRNA processing 66 1.44E-4
14 SGTC_928 2764-0428 3.61 58.7 µM 1.47E-4 cell wall 72 1.51E-4
15 SGTC_1895 st058434 3.58 18.3 µM 1.66E-4 21 1.70E-4
16 SGTC_1696 st025591 3.52 34.8 µM 2.12E-4 SWF1 & branched chain AA biosynthesis 40 2.18E-4
17 SGTC_2007 4011539 3.49 71.8 µM 2.39E-4 cell wall signaling 83 2.44E-4
18 SGTC_2957 9076800 3.45 11.5 µM 2.74E-4 32 2.80E-4
19 SGTC_2553 4-methylesculetin 3.31 85.1 µM 4.54E-4 48 4.63E-4
20 SGTC_2165 5727197 3.29 32.1 µM 4.85E-4 63 4.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.95E-14 YGL101W_p YGL101W_p hom Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
0.115 2.62E-11 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.113 6.22E-11 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.107 4.51E-10 YDR468C TLG1 het Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
0.105 1.27E-9 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.104 1.72E-9 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.095 3.54E-8 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.091 1.41E-7 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.089 2.61E-7 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.086 5.90E-7 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.085 9.15E-7 YGR275W RTT102 hom Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress
0.084 1.19E-6 YHR162W MPC2 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium
0.082 2.17E-6 YPR030W CSR2 hom Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication
0.079 4.25E-6 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.078 5.43E-6 YLR412C-A_p YLR412C-A_p hom Putative protein of unknown function