YLR189C / ATG26

UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR189C / ATG26

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.45|P-value:8.63E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.13|P-value:4.71E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.02|P-value:5.09E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.98|P-value:8.14E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.09|P-value:5.43E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.58|P-value:7.52E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.74|P-value:1.41E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:3.46|P-value:8.45E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.93|P-value:9.62E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.29|P-value:1.74E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.19|P-value:2.63E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.37|P-value:1.77E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.86|P-value:1.38E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:2.88|P-value:8.32E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.64|P-value:3.84E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.82|P-value:2.52E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.55|P-value:8.38E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.28|P-value:5.33E-9 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:3.24E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.35|P-value:1.32E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.04|P-value:6.42E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.29|P-value:5.03E-9 ID:SGTC_1262|Compound:0737-0114|FD-Score:8.03|P-value:2.13E-18 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.07|P-value:4.18E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.03|P-value:6.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:3.73E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.25|P-value:2.03E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.97|P-value:6.12E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.69|P-value:3.00E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.49|P-value:7.53E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.37|P-value:1.75E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-8.29|P-value:4.52E-19 ID:SGTC_1735|Compound:st034310|FD-Score:-3.30|P-value:2.38E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.01|P-value:5.14E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.57|P-value:8.15E-10 ID:SGTC_2178|Compound:5812956|FD-Score:-3.22|P-value:3.22E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:2.53E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.19|P-value:3.63E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.41|P-value:8.63E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.95|P-value:8.98E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.12|P-value:3.82E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-7.71|P-value:9.36E-17 ID:SGTC_3212|Compound:9128307|FD-Score:-3.19|P-value:3.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.45|P-value:8.63E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.13|P-value:4.71E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.02|P-value:5.09E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.98|P-value:8.14E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.09|P-value:5.43E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.58|P-value:7.52E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.74|P-value:1.41E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:3.46|P-value:8.45E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.93|P-value:9.62E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.29|P-value:1.74E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.19|P-value:2.63E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.37|P-value:1.77E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.86|P-value:1.38E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:2.88|P-value:8.32E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.64|P-value:3.84E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.82|P-value:2.52E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:-3.55|P-value:8.38E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.28|P-value:5.33E-9 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:3.24E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.35|P-value:1.32E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.04|P-value:6.42E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.29|P-value:5.03E-9 ID:SGTC_1262|Compound:0737-0114|FD-Score:8.03|P-value:2.13E-18 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.07|P-value:4.18E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.03|P-value:6.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.19|P-value:3.73E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.25|P-value:2.03E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:2.97|P-value:6.12E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.69|P-value:3.00E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.49|P-value:7.53E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.37|P-value:1.75E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-8.29|P-value:4.52E-19 ID:SGTC_1735|Compound:st034310|FD-Score:-3.30|P-value:2.38E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.01|P-value:5.14E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.57|P-value:8.15E-10 ID:SGTC_2178|Compound:5812956|FD-Score:-3.22|P-value:3.22E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:2.53E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.19|P-value:3.63E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.41|P-value:8.63E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:-2.95|P-value:8.98E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.12|P-value:3.82E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-7.71|P-value:9.36E-17 ID:SGTC_3212|Compound:9128307|FD-Score:-3.19|P-value:3.68E-4

Top fitness defect scores for YLR189C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1262 0737-0114 8.03 49.6 µM 2.13E-18 2 4.76E-16
2 SGTC_2130 NSC 7 5.57 2.5 µM 8.15E-10 copper-dependent oxidative stress 7 1.25E-8
3 SGTC_1257 0669-0121 5.29 16.0 µM 5.03E-9 8 6.03E-8
4 SGTC_1199 1638-0010 5.28 4.5 µM 5.33E-9 endomembrane recycling 3 6.34E-8
5 SGTC_734 2023-0417 4.74 80.0 µM 1.41E-7 ergosterol biosynthesis 6 1.08E-6
6 SGTC_2523 spermine 4.41 47.7 µM 8.63E-7 calcium & mitochondrial duress 22 5.15E-6
7 SGTC_2857 9024691 4.12 58.4 µM 3.82E-6 22 1.86E-5
8 SGTC_916 4466-0038 3.86 42.0 nM 1.38E-5 cell wall 72 5.64E-5
9 SGTC_1552 6-methylflavone 3.69 10.6 µM 3.00E-5 superoxide 21 1.11E-4
10 SGTC_1031 k035-0009 3.64 16.0 µM 3.84E-5 39 1.37E-4
11 SGTC_1554 st069299 3.49 38.7 µM 7.53E-5 35 2.46E-4
12 SGTC_746 1095-0025 3.46 46.6 µM 8.45E-5 RSC & ERG11 26 2.71E-4
13 SGTC_64 000l-0018 3.45 272.1 µM 8.63E-5 ubiquinone biosynthesis & proteasome 180 2.76E-4
14 SGTC_1209 2323-2347 3.35 50.3 µM 1.32E-4 29 3.99E-4
15 SGTC_886 0866-0150 3.29 153.0 µM 1.74E-4 43 5.07E-4
16 SGTC_1535 tetrahydropapaveroline hydrobromide 3.25 54.3 µM 2.03E-4 RPP1 & pyrimidine depletion 31 5.79E-4
17 SGTC_2335 9018011 3.19 154.2 µM 2.53E-4 57 7.01E-4
18 SGTC_899 1083-0020 3.19 478.0 µM 2.63E-4 51 7.23E-4
19 SGTC_1200 1643-0193 3.13 18.4 µM 3.24E-4 41 8.66E-4
20 SGTC_1266 0828-0227 3.07 32.9 µM 4.18E-4 58 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 9.87E-34 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.166 3.34E-22 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.165 6.64E-22 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.163 2.34E-21 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.152 9.20E-19 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.144 5.48E-17 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.140 3.44E-16 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.136 2.70E-15 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.134 7.61E-15 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.130 3.73E-14 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.130 5.15E-14 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.127 1.57E-13 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.126 2.34E-13 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.121 1.96E-12 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.117 8.70E-12 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis