YLR194C

Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR194C / YLR194C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.66|P-value:1.93E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.90|P-value:6.27E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.91|P-value:5.86E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.29|P-value:7.25E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.19|P-value:8.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.87|P-value:7.01E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.25|P-value:8.30E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.46|P-value:3.26E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.23|P-value:1.59E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.88|P-value:8.54E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:2.21E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.25|P-value:6.82E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.29|P-value:5.95E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.00|P-value:4.17E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:2.61E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.58|P-value:2.63E-4 ID:SGTC_2032|Compound:5185112|FD-Score:4.79|P-value:1.26E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.15|P-value:9.61E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.37|P-value:4.49E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.52|P-value:2.59E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.66|P-value:1.55E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.80|P-value:9.32E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.19|P-value:8.33E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.88|P-value:6.58E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.56|P-value:2.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.44|P-value:3.57E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.66|P-value:1.93E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.90|P-value:6.27E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.91|P-value:5.86E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.29|P-value:7.25E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.19|P-value:8.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.87|P-value:7.01E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.25|P-value:8.30E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.43|P-value:3.57E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.46|P-value:3.26E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.23|P-value:1.59E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.88|P-value:8.54E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.40|P-value:4.05E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.39|P-value:4.15E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:2.21E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.25|P-value:6.82E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.29|P-value:5.95E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.40|P-value:4.98E-4 ID:SGTC_1970|Compound:st070122|FD-Score:4.00|P-value:4.17E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.52|P-value:2.61E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.58|P-value:2.63E-4 ID:SGTC_2032|Compound:5185112|FD-Score:4.79|P-value:1.26E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.15|P-value:9.61E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.37|P-value:4.49E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.52|P-value:2.59E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.66|P-value:1.55E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.80|P-value:9.32E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.19|P-value:8.33E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.88|P-value:6.58E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.63|P-value:1.72E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.56|P-value:2.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.44|P-value:3.57E-4

Top fitness defect scores for YLR194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2032 5185112 4.79 26.0 µM 1.26E-6 6 8.39E-7
2 SGTC_1201 1889-3372 4.23 45.9 µM 1.59E-5 Golgi 7 1.18E-5
3 SGTC_1970 st070122 4.00 35.8 µM 4.17E-5 TSC3-RPN4 27 3.20E-5
4 SGTC_361 000s-0510 3.91 1.4 µM 5.86E-5 32 4.55E-5
5 SGTC_113 0099-0221 3.90 2.5 µM 6.27E-5 25 4.88E-5
6 SGTC_2667 digitoxin 3.88 100.0 µM 6.58E-5 2 5.12E-5
7 SGTC_813 k007-0158 3.87 173.0 µM 7.01E-5 fatty acid desaturase (OLE1) 44 5.48E-5
8 SGTC_2617 dihydrotanshinone i 3.80 20.8 µM 9.32E-5 copper-dependent oxidative stress 50 7.36E-5
9 SGTC_2477 5967686 3.66 25.2 µM 1.55E-4 33 1.24E-4
10 SGTC_2697 mebhydrolin 3.63 72.4 µM 1.72E-4 NEO1 83 1.39E-4
11 SGTC_1637 st007924 3.57 17.4 µM 2.21E-4 38 1.80E-4
12 SGTC_3210 9128157 3.56 49.5 µM 2.26E-4 66 1.84E-4
13 SGTC_717 1532-0246 3.53 73.2 µM 2.54E-4 Golgi 48 2.09E-4
14 SGTC_2295 7971645 3.52 200.0 µM 2.59E-4 36 2.12E-4
15 SGTC_1974 st069448 3.52 26.9 µM 2.61E-4 36 2.15E-4
16 SGTC_1002 4049-0206 3.46 172.0 µM 3.26E-4 56 2.70E-4
17 SGTC_3212 9128307 3.44 49.5 µM 3.57E-4 71 2.96E-4
18 SGTC_910 3454-3003 3.43 490.0 µM 3.57E-4 29 2.97E-4
19 SGTC_1600 coumarin 106 3.40 71.1 µM 4.05E-4 42 3.38E-4
20 SGTC_1620 st003704 3.39 16.5 µM 4.15E-4 34 3.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.79E-15 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.099 1.05E-8 YER187W_p YER187W_p hom Putative protein of unknown function; induced in respiratory-deficient cells
0.096 2.48E-8 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.093 8.05E-8 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.092 8.90E-8 YNR066C_p YNR066C_p hom Putative membrane-localized protein of unknown function
0.092 1.00E-7 YLL055W YCT1 hom High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
0.091 1.46E-7 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.090 1.66E-7 YER085C_p YER085C_p hom Putative protein of unknown function
0.086 5.89E-7 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.086 6.69E-7 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.085 8.93E-7 YIL137C TMA108 hom Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease
0.084 9.97E-7 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.082 1.79E-6 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
0.080 3.19E-6 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.079 5.09E-6 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate