YLR203C / MSS51

Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR203C / MSS51

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.17|P-value:2.56E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.87|P-value:8.07E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:2.19E-36 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:7.19E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:2.95|P-value:5.98E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.02|P-value:6.36E-19 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.90|P-value:8.80E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.24|P-value:1.85E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:2.82|P-value:9.78E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.72|P-value:2.26E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.61|P-value:3.69E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:2.90|P-value:7.25E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.90|P-value:7.19E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.60|P-value:3.90E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.40|P-value:9.52E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.09|P-value:3.31E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.09|P-value:3.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.46|P-value:4.58E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.96|P-value:6.62E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.72|P-value:2.22E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.64|P-value:1.65E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.81|P-value:1.40E-5 ID:SGTC_1635|Compound:st007035|FD-Score:8.77|P-value:2.92E-22 ID:SGTC_1744|Compound:st037937|FD-Score:4.06|P-value:4.30E-6 ID:SGTC_1746|Compound:st038117|FD-Score:-3.26|P-value:1.65E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.22|P-value:1.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-7.12|P-value:2.59E-15 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.80|P-value:1.44E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.98|P-value:6.07E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.33|P-value:1.33E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.73|P-value:2.18E-5 ID:SGTC_2113|Compound:5491891|FD-Score:2.84|P-value:9.12E-4 ID:SGTC_2165|Compound:5727197|FD-Score:2.97|P-value:5.68E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.16|P-value:2.64E-4 ID:SGTC_2281|Compound:7943571|FD-Score:2.89|P-value:7.77E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.00|P-value:2.04E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.92|P-value:6.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:7.96E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.91|P-value:6.83E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.95|P-value:5.75E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.03|P-value:4.37E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.02|P-value:4.52E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.15|P-value:2.73E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.00|P-value:4.99E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.00|P-value:5.03E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.37|P-value:1.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.51|P-value:5.90E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-5.89|P-value:4.89E-11 ID:SGTC_3192|Compound:9110362|FD-Score:-3.50|P-value:5.86E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.22|P-value:1.96E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.10|P-value:1.03E-8 ID:SGTC_3201|Compound:9113999|FD-Score:2.97|P-value:5.68E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.17|P-value:2.56E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.87|P-value:8.07E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:2.19E-36 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:7.19E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:2.95|P-value:5.98E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.02|P-value:6.36E-19 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.90|P-value:8.80E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.24|P-value:1.85E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:2.82|P-value:9.78E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.72|P-value:2.26E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.61|P-value:3.69E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:2.90|P-value:7.25E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.90|P-value:7.19E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.60|P-value:3.90E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:3.40|P-value:9.52E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.09|P-value:3.31E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.09|P-value:3.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.46|P-value:4.58E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.96|P-value:6.62E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.72|P-value:2.22E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.64|P-value:1.65E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.81|P-value:1.40E-5 ID:SGTC_1635|Compound:st007035|FD-Score:8.77|P-value:2.92E-22 ID:SGTC_1744|Compound:st037937|FD-Score:4.06|P-value:4.30E-6 ID:SGTC_1746|Compound:st038117|FD-Score:-3.26|P-value:1.65E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.22|P-value:1.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-7.12|P-value:2.59E-15 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.80|P-value:1.44E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.98|P-value:6.07E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.33|P-value:1.33E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.73|P-value:2.18E-5 ID:SGTC_2113|Compound:5491891|FD-Score:2.84|P-value:9.12E-4 ID:SGTC_2165|Compound:5727197|FD-Score:2.97|P-value:5.68E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.16|P-value:2.64E-4 ID:SGTC_2281|Compound:7943571|FD-Score:2.89|P-value:7.77E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.00|P-value:2.04E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-2.92|P-value:6.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.44|P-value:7.96E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.91|P-value:6.83E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.95|P-value:5.75E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.03|P-value:4.37E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.02|P-value:4.52E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.15|P-value:2.73E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.00|P-value:4.99E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.00|P-value:5.03E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.37|P-value:1.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.51|P-value:5.90E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-5.89|P-value:4.89E-11 ID:SGTC_3192|Compound:9110362|FD-Score:-3.50|P-value:5.86E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-3.22|P-value:1.96E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.10|P-value:1.03E-8 ID:SGTC_3201|Compound:9113999|FD-Score:2.97|P-value:5.68E-4

Top fitness defect scores for YLR203C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.40 5.3 µM 2.19E-36 160 1.59E-30
2 SGTC_1635 st007035 8.77 42.4 µM 2.92E-22 91 8.58E-19
3 SGTC_386 1509-0011 8.02 3.1 µM 6.36E-19 61 5.11E-16
4 SGTC_2563 tomatine 5.00 8.5 µM 2.04E-8 21 2.86E-7
5 SGTC_310 1273-0058 4.39 1.1 µM 7.19E-7 mitochondrial stress 217 5.59E-6
6 SGTC_1881 5652484 4.22 16.0 µM 1.79E-6 TRP & mitochondrial translation 25 1.20E-5
7 SGTC_1744 st037937 4.06 38.9 µM 4.30E-6 28 2.50E-5
8 SGTC_2097 5376186 3.73 200.0 µM 2.18E-5 29 9.72E-5
9 SGTC_1137 ixabepilone 3.72 100.0 µM 2.22E-5 34 9.85E-5
10 SGTC_643 k048-0106 3.72 28.4 µM 2.26E-5 RSC & ERG11 12 1.00E-4
11 SGTC_676 falcarinol 3.61 140.0 µM 3.69E-5 65 1.51E-4
12 SGTC_713 1488-1073 3.60 324.0 µM 3.90E-5 ERG2 19 1.58E-4
13 SGTC_2991 9074669 3.51 71.4 µM 5.90E-5 azole & statin 84 2.24E-4
14 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.44 100.0 µM 7.96E-5 40 2.88E-4
15 SGTC_735 3076-0345 3.40 636.0 µM 9.52E-5 47 3.34E-4
16 SGTC_1928 4'-methoxychalcone 3.34 40.3 µM 1.26E-4 27 4.22E-4
17 SGTC_1975 st070967 3.33 30.8 µM 1.33E-4 56 4.42E-4
18 SGTC_70 0141-0289 3.17 43.3 µM 2.56E-4 mitochondrial stress 255 7.68E-4
19 SGTC_2180 6301957 3.16 200.0 µM 2.64E-4 RSC complex & mRNA processing 21 7.87E-4
20 SGTC_2831 7999036 3.15 19.5 µM 2.73E-4 91 8.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.548 3.32E-262 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.517 4.03E-229 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.512 1.79E-223 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.503 4.50E-215 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.499 2.08E-210 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.494 8.78E-206 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.486 6.60E-198 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.485 7.67E-198 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.480 2.95E-193 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.473 2.40E-186 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.472 1.42E-185 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.470 1.08E-183 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.463 1.28E-177 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.459 1.59E-174 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.457 6.66E-173 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p