HIPHOP chemogenomics database

YLR208W / SEC13

Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR208W / SEC13

Click on Significant Values for Screen Details

Top fitness defect scores for YLR208W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1743	st037606	43.60	46.4 µM	3.97E-201		1	0	21.50
2	SGTC_3200	9114385	43.30	49.5 µM	1.01E-197		1	0	27.50
3	SGTC_2025	5147754	35.10	141.0 µM	1.20E-130		1	1.75E-269	20.70
4	SGTC_786	4544-0069	30.40	423.0 µM	1.30E-98		1	7.50E-203	23.70
5	SGTC_1420	4'-methoxyflavone	25.70	42.0 µM	4.00E-71		1	1.05E-145	19.40
6	SGTC_1416	3966-0321	25.50	25.3 µM	2.05E-70		1	3.16E-144	20.00
7	SGTC_290	2043-6722	22.20	48.1 µM	7.71E-54		1	8.80E-110	17.10
8	SGTC_3197	9113331	21.20	49.5 µM	3.41E-49		1	3.94E-100	9.74
9	SGTC_1655	st012546	20.40	55.1 µM	1.03E-45		1	6.69E-93	15.70
10	SGTC_878	0828-0289	19.80	13.7 µM	3.19E-43		1	9.90E-88	7.88
11	SGTC_993	3909-8757	19.80	62.7 µM	4.42E-43		1	1.96E-87	12.40
12	SGTC_723	4182-0001	19.60	115.0 µM	2.72E-42		1	8.52E-86	15.20
13	SGTC_2756	carbadox	17.90	75.1 µM	1.51E-35		1	8.47E-72	8.70
14	SGTC_138	0850-0259	17.30	40.9 µM	2.68E-33	cell wall	2	3.94E-67	1.97
15	SGTC_1026	k007-1105	16.80	30.6 µM	1.56E-31	ERAD & cell cycle	1	1.82E-63	4.23
16	SGTC_2488	5268135	15.50	45.7 µM	3.43E-27		1	1.84E-54	11.00
17	SGTC_1168	k815-0004	15.50	80.5 µM	3.52E-27	DNA damage response	1	1.94E-54	5.12
18	SGTC_89	0302-0250	14.20	142.1 µM	2.87E-23		1	2.49E-46	9.06
19	SGTC_790	1575-0012	14.10	79.1 µM	5.98E-23	TSC3-RPN4	1	1.13E-45	7.13
20	SGTC_2912	7964298	14.10	10.9 µM	6.58E-23	cell wall	5	1.38E-45	0.16

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.443	1.55E-161	YDL195W	SEC31	het	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
0.237	3.52E-44	YIL109C	SEC24	het	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.136	2.72E-15	YKR019C	IRS4	hom	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.132	2.05E-14	YDR108W	TRS85	hom	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.122	1.57E-12	YDR354W	TRP4	hom	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.115	2.18E-11	YBR156C	SLI15	hom	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.115	2.98E-11	YKL211C	TRP3	hom	Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.113	7.11E-11	YHR030C	SLT2	hom	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.113	6.18E-11	YLL021W	SPA2	hom	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.112	8.35E-11	YDR008C_d	YDR008C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112	1.07E-10	YDR127W	ARO1	hom	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.107	5.45E-10	YPL066W	RGL1	hom	Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.106	6.38E-10	YKL076C_d	PSY1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.106	7.35E-10	YJL095W	BCK1	hom	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.106	8.04E-10	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2