YLR209C / PNP1

Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR209C / PNP1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.29|P-value:6.67E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:-3.95|P-value:5.74E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.68|P-value:1.63E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-4.73|P-value:2.03E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.21|P-value:1.99E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.49|P-value:3.27E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.22|P-value:8.21E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.00|P-value:4.79E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.35|P-value:5.32E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.56|P-value:2.89E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.21|P-value:9.64E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.24|P-value:7.77E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.35|P-value:5.33E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.78|P-value:1.12E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-5.86|P-value:5.75E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-4.98|P-value:6.10E-7 ID:SGTC_2285|Compound:7945142|FD-Score:6.49|P-value:1.54E-10 ID:SGTC_2291|Compound:7917025|FD-Score:4.01|P-value:5.21E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-9.25|P-value:1.12E-19 ID:SGTC_2320|Compound:7373003|FD-Score:3.86|P-value:9.29E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:6.22E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.75|P-value:1.44E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.13|P-value:3.21E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-5.68|P-value:1.58E-8 ID:SGTC_2479|Compound:5617353|FD-Score:-4.31|P-value:1.31E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.38|P-value:5.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.20|P-value:8.79E-4 ID:SGTC_3206|Compound:9114350|FD-Score:5.64|P-value:2.32E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.98|P-value:5.80E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.72|P-value:1.61E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.29|P-value:6.67E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:-3.95|P-value:5.74E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.68|P-value:1.63E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-4.73|P-value:2.03E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.21|P-value:1.99E-5 ID:SGTC_512|Compound:prima-1|FD-Score:-3.49|P-value:3.27E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.22|P-value:8.21E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.00|P-value:4.79E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.35|P-value:5.32E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.56|P-value:2.89E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.21|P-value:9.64E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.24|P-value:7.77E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.35|P-value:5.33E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.78|P-value:1.12E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-5.86|P-value:5.75E-9 ID:SGTC_2284|Compound:7945075|FD-Score:-4.98|P-value:6.10E-7 ID:SGTC_2285|Compound:7945142|FD-Score:6.49|P-value:1.54E-10 ID:SGTC_2291|Compound:7917025|FD-Score:4.01|P-value:5.21E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-9.25|P-value:1.12E-19 ID:SGTC_2320|Compound:7373003|FD-Score:3.86|P-value:9.29E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:6.22E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.75|P-value:1.44E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.13|P-value:3.21E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-5.68|P-value:1.58E-8 ID:SGTC_2479|Compound:5617353|FD-Score:-4.31|P-value:1.31E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.42|P-value:4.26E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.38|P-value:5.39E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-3.20|P-value:8.79E-4 ID:SGTC_3206|Compound:9114350|FD-Score:5.64|P-value:2.32E-8 ID:SGTC_3301|Compound:9125354|FD-Score:3.98|P-value:5.80E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.72|P-value:1.61E-4

Top fitness defect scores for YLR209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2285 7945142 6.49 200.0 µM 1.54E-10 2 4.22E-11
2 SGTC_3206 9114350 5.64 49.5 µM 2.32E-8 2 8.61E-9
3 SGTC_2424 5537928 4.13 59.2 µM 3.21E-5 33 1.83E-5
4 SGTC_2291 7917025 4.01 104.3 µM 5.21E-5 iron homeostasis 46 3.05E-5
5 SGTC_3301 9125354 3.98 19.8 µM 5.80E-5 15 3.43E-5
6 SGTC_2320 7373003 3.86 200.0 µM 9.29E-5 29 5.64E-5
7 SGTC_2423 st077119 3.75 87.2 µM 1.44E-4 18 8.95E-5
8 SGTC_3317 9138495 3.72 8.8 µM 1.61E-4 36 1.01E-4
9 SGTC_757 1066-0008 3.56 322.0 µM 2.89E-4 Golgi 30 1.87E-4
10 SGTC_2792 7535235 3.38 81.8 µM 5.39E-4 fatty acid desaturase (OLE1) 54 3.64E-4
11 SGTC_2333 9017922 3.34 200.0 µM 6.22E-4 49 4.22E-4
12 SGTC_1443 4112-3303 3.21 14.0 µM 9.64E-4 24 6.72E-4
13 SGTC_2614 arthonioic acid 3.14 13.4 µM 0.00118 49 8.36E-4
14 SGTC_2117 5521686 3.05 200.0 µM 0.00161 56 0.00116
15 SGTC_1006 4099-6547 3.03 255.0 µM 0.00171 72 0.00124
16 SGTC_993 3909-8757 3.00 62.7 µM 0.00186 64 0.00135
17 SGTC_1131 3454-3128 2.95 32.3 µM 0.00218 96 0.00159
18 SGTC_1233 0325-0408 2.92 14.2 µM 0.00237 65 0.00174
19 SGTC_3005 9076496 2.87 71.4 µM 0.00278 38 0.00206
20 SGTC_2194 5927483 2.86 104.5 µM 0.00282 67 0.00209

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.49E-15 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.114 2.98E-11 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.111 1.36E-10 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.12E-10 YDR013W PSF1 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.107 6.02E-10 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.104 1.48E-9 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.102 3.80E-9 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.101 4.97E-9 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.100 5.66E-9 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.100 5.84E-9 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.097 1.53E-8 YNL158W PGA1 het Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
0.097 1.68E-8 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.095 3.72E-8 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.089 2.43E-7 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
0.089 2.81E-7 YPL138C SPP1 hom Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein