YLR210W / CLB4

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR210W / CLB4

Click on Significant Values for Screen Details ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.79|P-value:8.22E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.35|P-value:4.40E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.86|P-value:6.86E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:5.08|P-value:2.03E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.32|P-value:8.74E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.18|P-value:7.48E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.70|P-value:1.11E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.55|P-value:2.08E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.14|P-value:8.70E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.13|P-value:9.44E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.90|P-value:4.95E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.15|P-value:8.89E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-6.71|P-value:1.24E-11 ID:SGTC_2957|Compound:9076800|FD-Score:-3.43|P-value:3.27E-4 ID:SGTC_2969|Compound:9091408|FD-Score:5.03|P-value:2.54E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.69|P-value:1.47E-6 ID:SGTC_2987|Compound:9018338|FD-Score:3.40|P-value:3.48E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.03|P-value:2.88E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.54|P-value:2.03E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.34|P-value:7.38E-6 ID:SGTC_3198|Compound:9112019|FD-Score:5.52|P-value:1.78E-8 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.79|P-value:8.22E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.35|P-value:4.40E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.86|P-value:6.86E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:5.08|P-value:2.03E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:3.33|P-value:4.39E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.32|P-value:8.74E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.18|P-value:7.48E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.20|P-value:7.08E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.65|P-value:1.41E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.70|P-value:1.11E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.55|P-value:2.08E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.14|P-value:8.70E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.13|P-value:9.44E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.90|P-value:4.95E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.15|P-value:8.89E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-6.71|P-value:1.24E-11 ID:SGTC_2957|Compound:9076800|FD-Score:-3.43|P-value:3.27E-4 ID:SGTC_2969|Compound:9091408|FD-Score:5.03|P-value:2.54E-7 ID:SGTC_2974|Compound:9094440|FD-Score:4.69|P-value:1.47E-6 ID:SGTC_2987|Compound:9018338|FD-Score:3.40|P-value:3.48E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.03|P-value:2.88E-5 ID:SGTC_3145|Compound:9085516|FD-Score:3.54|P-value:2.03E-4 ID:SGTC_3189|Compound:9110682|FD-Score:4.34|P-value:7.38E-6 ID:SGTC_3198|Compound:9112019|FD-Score:5.52|P-value:1.78E-8

Top fitness defect scores for YLR210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3198 9112019 5.52 49.5 µM 1.78E-8 mitochondrial processes 2 1.65E-8
2 SGTC_778 3456-2434 5.08 196.0 µM 2.03E-7 mitochondrial response to ROS 44 1.90E-7
3 SGTC_2969 9091408 5.03 28.7 µM 2.54E-7 10 2.39E-7
4 SGTC_2974 9094440 4.69 9.7 µM 1.47E-6 ergosterol biosynthesis 30 1.39E-6
5 SGTC_3189 9110682 4.34 49.5 µM 7.38E-6 27 7.08E-6
6 SGTC_3143 9086658 4.03 49.5 µM 2.88E-5 42 2.79E-5
7 SGTC_2436 5633522 3.90 8.1 µM 4.95E-5 17 4.81E-5
8 SGTC_850 0388-0143 3.76 75.9 µM 8.80E-5 15 8.56E-5
9 SGTC_2591 skatole 3.73 100.0 µM 9.65E-5 30 9.39E-5
10 SGTC_1747 st037496 3.70 66.6 µM 1.11E-4 22 1.08E-4
11 SGTC_1044 1222-0021 3.56 1.8 µM 1.91E-4 heme biosynthesis & mitochondrial translocase 48 1.87E-4
12 SGTC_3145 9085516 3.54 49.5 µM 2.03E-4 fatty acid desaturase (OLE1) 42 1.99E-4
13 SGTC_2371 9071574 3.48 200.0 µM 2.52E-4 25 2.47E-4
14 SGTC_2987 9018338 3.40 71.4 µM 3.48E-4 RPP1 & pyrimidine depletion 39 3.41E-4
15 SGTC_780 0109-0199 3.33 192.0 µM 4.39E-4 41 4.31E-4
16 SGTC_1125 tnp00248 3.20 1.3 µM 7.08E-4 79 6.97E-4
17 SGTC_995 3931-2021 3.18 34.6 µM 7.48E-4 RPP1 & pyrimidine depletion 47 7.36E-4
18 SGTC_2155 5570423 3.14 76.0 µM 8.70E-4 ergosterol biosynthesis 32 8.57E-4
19 SGTC_1673 st016611 3.09 27.3 µM 0.00102 88 0.00100
20 SGTC_2334 9017922 3.06 200.0 µM 0.00113 56 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 1.45E-39 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 4.68E-35 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 5.80E-19 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.150 3.14E-18 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.144 5.90E-17 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.143 9.34E-17 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.140 4.23E-16 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.137 1.48E-15 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.134 5.30E-15 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.130 4.49E-14 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.128 8.78E-14 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.125 3.39E-13 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.122 1.20E-12 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.118 5.72E-12 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.117 9.59E-12 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel