YLR214W / FRE1

Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR214W / FRE1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.01|P-value:6.19E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.51|P-value:7.23E-7 ID:SGTC_263|Compound:alizarin|FD-Score:3.49|P-value:9.20E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.05|P-value:7.36E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.16|P-value:1.81E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:3.50|P-value:9.12E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.99|P-value:9.86E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-6.93|P-value:1.63E-13 ID:SGTC_427|Compound:1354-0053|FD-Score:3.18|P-value:3.22E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.30|P-value:2.87E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.45|P-value:1.55E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:2.97|P-value:7.21E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.32|P-value:1.93E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.09|P-value:6.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.31|P-value:2.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:5.42E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.00|P-value:6.43E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.20|P-value:4.12E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.08|P-value:6.40E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.23|P-value:2.69E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.58|P-value:8.93E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.33|P-value:2.54E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.43|P-value:1.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.68|P-value:4.50E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.17|P-value:3.36E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.90|P-value:9.15E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.20|P-value:2.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.65|P-value:3.51E-7 ID:SGTC_2400|Compound:5203494|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:2.55E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.59|P-value:8.82E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.06|P-value:6.95E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.04|P-value:7.59E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.04|P-value:1.08E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.84|P-value:2.93E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-5.56|P-value:2.60E-9 ID:SGTC_2968|Compound:9090663|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_3262|Compound:9137218|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.28|P-value:2.25E-4 ID:SGTC_3310|Compound:9130229|FD-Score:2.96|P-value:7.53E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.12|P-value:4.17E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-4.25|P-value:4.29E-6 ID:SGTC_3355|Compound:9151058|FD-Score:-3.51|P-value:1.23E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.01|P-value:6.19E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:4.51|P-value:7.23E-7 ID:SGTC_263|Compound:alizarin|FD-Score:3.49|P-value:9.20E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.05|P-value:7.36E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.16|P-value:1.81E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:3.50|P-value:9.12E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.99|P-value:9.86E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-6.93|P-value:1.63E-13 ID:SGTC_427|Compound:1354-0053|FD-Score:3.18|P-value:3.22E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.30|P-value:2.87E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.45|P-value:1.55E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:2.97|P-value:7.21E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:4.32|P-value:1.93E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.09|P-value:6.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.31|P-value:2.68E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:5.42E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.00|P-value:6.43E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.20|P-value:4.12E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.95|P-value:7.76E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.08|P-value:6.40E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.23|P-value:2.69E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.58|P-value:8.93E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.33|P-value:2.54E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.43|P-value:1.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.68|P-value:4.50E-7 ID:SGTC_2109|Compound:5483026|FD-Score:3.17|P-value:3.36E-4 ID:SGTC_2116|Compound:5511452|FD-Score:2.90|P-value:9.15E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.20|P-value:2.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.65|P-value:3.51E-7 ID:SGTC_2400|Compound:5203494|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:2.55E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.59|P-value:8.82E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.06|P-value:6.95E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.04|P-value:7.59E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-6.04|P-value:1.08E-10 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.84|P-value:2.93E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-5.56|P-value:2.60E-9 ID:SGTC_2968|Compound:9090663|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_3262|Compound:9137218|FD-Score:2.95|P-value:7.77E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.28|P-value:2.25E-4 ID:SGTC_3310|Compound:9130229|FD-Score:2.96|P-value:7.53E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.12|P-value:4.17E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-4.25|P-value:4.29E-6 ID:SGTC_3355|Compound:9151058|FD-Score:-3.51|P-value:1.23E-4

Top fitness defect scores for YLR214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_329 k048-0121 5.16 21.3 µM 1.81E-8 RSC & ERG11 4 1.20E-7
2 SGTC_2398 5228213 4.65 48.8 µM 3.51E-7 iron homeostasis 22 1.68E-6
3 SGTC_67 0335-0847 4.51 266.0 µM 7.23E-7 ubiquinone biosynthesis & proteasome 94 3.20E-6
4 SGTC_940 3232-1287 4.32 54.8 µM 1.93E-6 NEO1 25 7.66E-6
5 SGTC_1562 morin hydrate 4.08 59.1 µM 6.40E-6 15 2.23E-5
6 SGTC_367 0335-0881 3.99 7.1 µM 9.86E-6 ubiquinone biosynthesis & proteasome 78 3.27E-5
7 SGTC_1185 1319-0113 3.62 81.3 µM 5.42E-5 DNA damage response 18 1.49E-4
8 SGTC_359 0081-0058 3.50 15.9 µM 9.12E-5 60S ribosome export 65 2.37E-4
9 SGTC_263 alizarin 3.49 107.9 µM 9.20E-5 iron homeostasis 81 2.39E-4
10 SGTC_3299 9121982 3.28 43.1 µM 2.25E-4 57 5.28E-4
11 SGTC_1569 carminic acid 3.23 40.6 µM 2.69E-4 43 6.20E-4
12 SGTC_2348 9022543 3.20 33.4 µM 2.99E-4 mitochondrial processes 53 6.82E-4
13 SGTC_427 1354-0053 3.18 47.3 µM 3.22E-4 55 7.27E-4
14 SGTC_2109 5483026 3.17 200.0 µM 3.36E-4 RSC complex & mRNA processing 66 7.55E-4
15 SGTC_3340 9146634 3.12 11.1 µM 4.17E-4 47 9.15E-4
16 SGTC_64 000l-0018 3.07 272.1 µM 4.92E-4 ubiquinone biosynthesis & proteasome 216 0.00106
17 SGTC_2968 9090663 3.07 33.4 µM 5.05E-4 69 0.00109
18 SGTC_15 0266-0086 3.01 27.1 µM 6.19E-4 endomembrane recycling 117 0.00130
19 SGTC_1135 dihydrocapsaicin 3.00 536.7 nM 6.42E-4 80 0.00134
20 SGTC_1376 2910-0861 3.00 41.3 µM 6.43E-4 72 0.00135

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.41E-16 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.130 4.62E-14 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.128 1.06E-13 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.126 2.99E-13 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.126 3.01E-13 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.119 5.53E-12 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.115 2.93E-11 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.107 4.47E-10 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.103 2.44E-9 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.102 3.51E-9 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.100 6.70E-9 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.098 1.24E-8 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.41E-8 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.095 3.58E-8 YLR008C PAM18 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
0.092 1.08E-7 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis