YLR217W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR217W / YLR217W

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.81|P-value:7.68E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.15|P-value:8.59E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.37|P-value:4.82E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.75|P-value:1.18E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.50|P-value:3.20E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.28|P-value:1.29E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.27|P-value:6.73E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.05|P-value:3.47E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.67|P-value:1.33E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.16|P-value:9.86E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.16|P-value:8.42E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.35|P-value:4.31E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.25|P-value:6.29E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.31|P-value:1.14E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.43|P-value:3.27E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.16|P-value:8.40E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.84|P-value:8.27E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.82|P-value:7.53E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-3.25|P-value:6.25E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.91|P-value:6.24E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.54|P-value:2.15E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.81|P-value:7.68E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.15|P-value:8.59E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.37|P-value:4.82E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.75|P-value:1.18E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.63|P-value:1.58E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.50|P-value:3.20E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.28|P-value:1.29E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.28|P-value:6.46E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.27|P-value:6.73E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:4.05|P-value:3.47E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.31|P-value:5.01E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.67|P-value:1.33E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.16|P-value:9.86E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.16|P-value:8.42E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.57|P-value:2.28E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.35|P-value:4.31E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.25|P-value:6.29E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.56|P-value:2.38E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.31|P-value:1.14E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.43|P-value:3.27E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.16|P-value:8.40E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.84|P-value:8.27E-5 ID:SGTC_3125|Compound:9127534|FD-Score:-3.82|P-value:7.53E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-3.25|P-value:6.25E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.91|P-value:6.24E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.54|P-value:2.15E-4

Top fitness defect scores for YLR217W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_365 0121-0052 5.50 13.6 µM 3.20E-8 mitochondrial response to ROS 20 1.89E-8
2 SGTC_2450 5739737 4.31 12.9 µM 1.14E-5 17 8.01E-6
3 SGTC_445 e6 berbamine 4.28 66.0 µM 1.29E-5 NEO1-PIK1 90 9.15E-6
4 SGTC_693 4161-2696 4.05 114.0 µM 3.47E-5 8 2.53E-5
5 SGTC_3134 9127454 3.91 49.5 µM 6.24E-5 14 4.63E-5
6 SGTC_2806 7952793 3.84 58.4 µM 8.27E-5 23 6.19E-5
7 SGTC_292 k038-0015 3.75 474.0 µM 1.18E-4 10 8.90E-5
8 SGTC_952 1185-0122 3.57 232.0 µM 2.28E-4 30 1.76E-4
9 SGTC_2253 7938677 3.56 135.8 µM 2.38E-4 20 1.84E-4
10 SGTC_983 1491-0821 3.53 12.2 µM 2.73E-4 24 2.12E-4
11 SGTC_221 trifluoperazine 3.37 10.3 µM 4.82E-4 NEO1-PIK1 245 3.81E-4
12 SGTC_449 xestospongin c 3.28 11.2 µM 6.46E-4 NEO1-PIK1 108 5.15E-4
13 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.27 150.0 µM 6.73E-4 Golgi 68 5.37E-4
14 SGTC_2688 kanamycin b 3.19 96.7 µM 8.75E-4 calcium & mitochondrial duress 497 7.04E-4
15 SGTC_741 4582-0002 3.16 126.0 µM 9.86E-4 43 7.97E-4
16 SGTC_929 2805-0021 3.12 398.0 µM 0.00111 46 9.02E-4
17 SGTC_312 4092-0653 3.08 6.8 µM 0.00129 ergosterol depletion effects on membrane 132 0.00105
18 SGTC_549 1661-1316 2.98 519.0 µM 0.00174 58 0.00143
19 SGTC_3123 9126162 2.92 49.5 µM 0.00211 54 0.00174
20 SGTC_2969 9091408 2.92 28.7 µM 0.00214 87 0.00177

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.73E-19 YDR156W RPA14 hom RNA polymerase I subunit A14
0.143 8.26E-17 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.74E-16 YDR508C GNP1 hom High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication
0.138 1.06E-15 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.132 1.40E-14 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.127 1.39E-13 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.115 2.03E-11 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.114 3.48E-11 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.113 5.35E-11 YDR125C ECM18 hom Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication
0.112 7.85E-11 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.112 8.84E-11 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.108 3.25E-10 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.108 3.73E-10 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.107 5.18E-10 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.107 5.42E-10 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol